| Ryburn Limited | Professional & scientific | 2020 |
| Rydall Ltd | Professional & scientific | 2024 |
| RYE Bay Limited | Hospitality | 2004 |
| RYE Bay Suites Ltd | Real estate | 2025 |
| RYE Island Limited | Administrative & support | 2018 |
| Ryzan Ltd | Information & communication | 2025 |
| Ryzons Services Ltd | Wholesale & retail | 2026 |
| S & P Property Developers Ltd | Construction | 2025 |
| S and C Osteopathy Ltd | Health & social care | 2024 |
| S Bass Holdings UK Limited | Administrative & support | 2011 |
| S E Jenner and Sons LLP | | 2023 |
| S G Knight Consultancy Limited | Information & communication | 2006 |
| S J Pyne Heating & Plumbing Ltd | Construction | 2017 |
| S R B Refurbishments Ltd | Construction | 2022 |
| S R Nelson Associates Limited | Wholesale & retail | 1997 |
| S T Robertson Ltd | Professional & scientific | 2023 |
| S Wainwright Ltd | Information & communication | 2023 |
| S&G Property Investments Limited | Real estate | 2019 |
| S&L Electrical London Ltd | Construction | 2018 |
| S&P Construction (Kent) Limited | Extraterritorial | 2013 |
| S. Small (Builders) Limited | Real estate | 1969 |
| S.C.G.Kent Ltd | Construction | 2011 |
| S.T Logistics Solutions Ltd | Manufacturing | 2013 |
| S2 Brand Limited | Professional & scientific | 2020 |
| SA Landscaping Ltd | Administrative & support | 2023 |
| Saak Limited | Financial services | 2015 |
| Saak Realty Ltd | Real estate | 2022 |
| SAB Physiotherapy Ltd | Health & social care | 2018 |
| Sabeel Management LLP | | 2011 |
| Sabercom Ltd | Information & communication | 2009 |
| Sace Socials Ltd | Professional & scientific | 2025 |
| Sackville School Limited | Education | 2017 |
| Safe and Care Ltd | Health & social care | 2015 |
| Safe and Easy Self Storage Ltd | Transport & logistics | 2024 |
| Safe Lock Containers UK Limited | Administrative & support | 2025 |
| Safe Working Lifts London Ltd | Manufacturing | 2026 |
| Safesignal Limited | Information & communication | 2026 |
| Sage Build Ltd | Construction | 2024 |
| Saha Property Holdings Limited | Real estate | 2024 |
| SAI Imaging and Medical Services Limited | Health & social care | 2015 |
| SAI Medics Ltd | Health & social care | 2022 |
| SAI Vikarshini Consultancy Limited | Information & communication | 2019 |
| Saint Agnes Rods, Lines and Tubes Ltd | Agriculture & fishing | 2026 |
| Saint George's Shoulder Unit Research and Education Group C.I.C. | Education | 2016 |
| Saint's Hill Properties Limited | Construction | 1998 |
| Sakura Logistics Ltd | Transport & logistics | 2026 |
| SAL Holdco Limited | Transport & logistics | 2018 |
| Salcombe Brew Ltd | Administrative & support | 2016 |
| Salient Process UK Limited | Information & communication | 2020 |
| Salinas 2017 Ltd | Professional & scientific | 2017 |
| Salon British Brands Limited | Wholesale & retail | 2018 |
| Salter Catering Limited | Hospitality | 1997 |
| SAM Bean Ltd | Professional & scientific | 2025 |
| SAM Holdings (UK) Ltd | Financial services | 2008 |
| SAM Taxi Tonbridge Limited | Transport & logistics | 2024 |
| Samalex Solutions Limited | Professional & scientific | 2022 |
| Samarise Supply Limited | Wholesale & retail | 2026 |
| Samarkand Global Limited | Information & communication | 2016 |
| Samarkand Group Limited | Professional & scientific | 2021 |
| Samarkand Holdings Limited | Professional & scientific | 2017 |
| Samel Risk & Compliance Ltd | Professional & scientific | 2026 |
| Samknee Ltd | Health & social care | 2024 |
| Samways Electrical Limited | Construction | 2002 |
| Samza Limited | Financial services | 2014 |
| Sanctus Luna Limited | Information & communication | 2025 |
| Sandison Lang Ltd | Professional & scientific | 2013 |
| Sandla Consulting Ltd | Professional & scientific | 2023 |
| Sandstone Property Developers Limited | Construction | 2026 |
| Sanitap Ltd | Manufacturing | 2020 |
| Sansom Sound Limited | Information & communication | 2016 |
| Santé Frontiers Group Ltd. | Hospitality | 2025 |
| Saoirse Interiors Limited | Other services | 2013 |
| SAP Care Services Limited | Health & social care | 2011 |
| Sapcs Solutions Ltd | Information & communication | 2010 |
| Sapphire Landscapes Limited | Construction | 2025 |
| Sapphire Risk Transfer UK Limited | Financial services | 2019 |
| SAQ Speed Agility Quickness Ltd | Education | 2020 |
| Sara Coles Limited | Professional & scientific | 2013 |
| Saradeen Ltd | Real estate | 2026 |
| Sarah J Moss Limited | Administrative & support | 2021 |
| Sarahcarolides Limited | Health & social care | 2017 |
| Saratoga Ltd | Health & social care | 2026 |
| Sarissa Properties Limited | Hospitality | 2012 |
| Saroe Ltd | Manufacturing | 2025 |
| SAS Driver Ltd | Transport & logistics | 2019 |
| Sash Radiology Ltd. | Health & social care | 2023 |
| Sashy & Sashy Holdings Limited | Construction | 2023 |
| Sauce&Scale Ltd | Professional & scientific | 2026 |
| Saunders Leisure Limited | Real estate | 2023 |
| Savi Consulting Limited | Information & communication | 2007 |
| Savington Consulting Limited | Administrative & support | 2020 |
| Savoy Plaza Ltd | Real estate | 2019 |
| Sawmill Management Ltd | Real estate | 2024 |
| Sawyer & Sons Trading Ltd | Financial services | 2025 |
| Saxons Services Limited | Administrative & support | 2021 |
| SC Driving Ltd | Education | 2026 |
| SC Neuroimaging Ltd | Health & social care | 2024 |
| SC Simulator Designs Ltd | Information & communication | 2021 |
| Scanwave Diagnostics Limited | Health & social care | 2025 |
| Scarab Holdings Limited | Professional & scientific | 1987 |