| Special Purpose Vehicle Ltd | Real estate | 2022 |
| Speed With Design Limited | Wholesale & retail | 2014 |
| Speedcrys Ltd | Transport & logistics | 2016 |
| Speedy Ride Limited | Transport & logistics | 2025 |
| Spencer Reid Consulting Ltd | Professional & scientific | 2025 |
| Spice Masala (Donnington) Ltd | Hospitality | 2022 |
| Spice of Telford Ltd | Hospitality | 2025 |
| Spice&Sipp Limited | Hospitality | 2025 |
| Spice'N'Soul Vegan Café Ltd | Hospitality | 2026 |
| Spiloh Property Ltd | Real estate | 2016 |
| Spinning Chicken Gifts Ltd | Wholesale & retail | 2024 |
| Spiral Galaxy Games Limited | Manufacturing | 2009 |
| Spirit Occupational Health Service Ltd | Other services | 2012 |
| Spirit of Mambo Ltd | Hospitality | 2025 |
| Spirit of the UK Limited | Manufacturing | 2020 |
| Spitfire Softwash Limited | Construction | 2022 |
| Spittle Art Provisions Limited | Construction | 2024 |
| Splintered Shields Ltd | Arts & recreation | 2025 |
| Sponna Ltd | Other services | 2018 |
| Spooks Corner Ltd | Wholesale & retail | 2026 |
| Spore Property Solutions Ltd | Real estate | 2026 |
| Sport 4 Schools Coaching UK Limited | Arts & recreation | 2013 |
| Sport HQ Group Ltd | Information & communication | 2024 |
| Spot on Drylining Ltd | Construction | 2021 |
| Spotless AI Ltd | Manufacturing | 2018 |
| Spotless Cleaning Crew Limited | Administrative & support | 2026 |
| Spotlight Telecommunications Limited | Information & communication | 2013 |
| Spotlight Telecoms Ltd | Information & communication | 2012 |
| SPR Supplies Ltd | Wholesale & retail | 2024 |
| Spraytech Auto Repairs Ltd | Wholesale & retail | 2020 |
| Springboard Insights Ltd | Education | 2024 |
| Springside Care Solutions Ltd | Health & social care | 2023 |
| Sprinkler Tech Ltd | Construction | 2009 |
| Sprint Tool and DIE Limited | Manufacturing | 1989 |
| Sprinter Removals Ltd | Transport & logistics | 2025 |
| Spruk Property Management Ltd | Households | 2026 |
| SQH Ltd | Information & communication | 2019 |
| Square Two Consulting Limited | Professional & scientific | 2022 |
| Squiffy Head Ltd | Other services | 2013 |
| Squirrel Software Ltd | Information & communication | 2024 |
| Squish Marketing Ltd | Professional & scientific | 2021 |
| SR Plumbing & Heating (Telford) Limited | Manufacturing | 2016 |
| Sraan Food Productions Ltd | Manufacturing | 2025 |
| SRD Property Developments Ltd | Real estate | 2019 |
| SRD Telford Ltd | Real estate | 2020 |
| SRI Bala Vinayaga Retail Ltd | Wholesale & retail | 2023 |
| SRI Sathya SAI Properties Limited | Real estate | 2021 |
| Sridans Ltd | Other services | 2020 |
| Srinivasan Medical Services Limited | Health & social care | 2017 |
| Srps Walsh Limited | Professional & scientific | 2019 |
| Srvnet Ltd | Information & communication | 2023 |
| Srvwire Property Protection Ltd | Administrative & support | 2020 |
| Srvwire Tech Ltd | Information & communication | 2017 |
| SS Group Holdings Limited | Financial services | 2022 |
| SS Safety Services Ltd | Construction | 2024 |
| Ssafe Limited | Administrative & support | 2022 |
| SSG Haulage Limited | Transport & logistics | 2014 |
| Ssgj Ltd | Financial services | 2025 |
| SSH Flexilease Limited | Administrative & support | 2016 |
| SSJ Autos Ltd | Wholesale & retail | 2022 |
| SSJ IT Limited | Information & communication | 2025 |
| SSJ Transport Ltd | Transport & logistics | 2026 |
| Ssjq Veldor Limited | Construction | 2024 |
| Ssks Consulting Limited | Information & communication | 2016 |
| SSR Medicals Limited | Health & social care | 2012 |
| ST Catharines Court Management Ltd | Households | 2021 |
| ST James (Shropshire) Limited | Construction | 2020 |
| ST Marys House Management Ltd | Households | 2020 |
| ST. George's Funeral Services Ltd | Professional & scientific | 2013 |
| Stackbuild Limited | Manufacturing | 2023 |
| Stadco Automotive Limited | Professional & scientific | 2010 |
| Stadco Limited | Manufacturing | 1874 |
| Staff Innovation Ltd | Professional & scientific | 2025 |
| Staffing LAB Limited | Administrative & support | 2019 |
| Stafford Park ETL Limited | Education | 2014 |
| Stafford Park Investments Ltd | Real estate | 2016 |
| Staffordshire Kitchens and Bathrooms Ltd | Wholesale & retail | 2022 |
| Staffordshire Sand & Gravel Company Limited | Professional & scientific | 2006 |
| Stag Services Ltd | Construction | 2018 |
| Stagecraftuk Limited | Professional & scientific | 2010 |
| Stairplan Limited | Manufacturing | 2001 |
| Stanage Investments Ltd | Financial services | 2004 |
| Stancolin Company Limited | Real estate | 2024 |
| Standard Holdings Ltd | Financial services | 2025 |
| Stansrow Limited | Construction | 2021 |
| Star Cleaning (UK) Ltd | Administrative & support | 2013 |
| Star Emporium Ltd | Wholesale & retail | 2020 |
| Star Resourcing Ltd | Real estate | 2026 |
| Star Seven Management Ltd | Real estate | 2022 |
| Star Timepiece Company Ltd | Manufacturing | 2025 |
| Star Your World Limited | Administrative & support | 2018 |
| Starforce Security Limited | Administrative & support | 2023 |
| Starks Corporation Ltd | Wholesale & retail | 2020 |
| Starling Aesthetics Ltd | Other services | 2021 |
| Starplus Recruitment Limited | Administrative & support | 2026 |
| Stars Education Ltd | Education | 2023 |
| Start Technology (Software) Limited | Information & communication | 2006 |
| Station Dental Holdings Limited | Real estate | 2020 |
| Station Road Stores Ltd | Wholesale & retail | 2022 |
| Station Three CIC | Other services | 2026 |