| Staubli (UK) Limited | Other services | 1988 |
| Stay Charity | Hospitality | 1997 |
| Stay Sharp Media Ltd | Wholesale & retail | 2021 |
| STB Property Investment Limited | Real estate | 2017 |
| STB Sales Ltd | Professional & scientific | 2023 |
| STC Home Improvements Limited | Construction | 2002 |
| Steadwell Ltd | Real estate | 2025 |
| Steel Street Ltd | Manufacturing | 2023 |
| Steel Window Fittings Ltd | Manufacturing | 2011 |
| Steele Trade Ltd | Manufacturing | 2021 |
| Stefan Baldovin Ltd | Construction | 2025 |
| Stekwa Healthcare Services Limited | Health & social care | 2025 |
| Step Forward Support Group Ltd | Health & social care | 2025 |
| Step Forward Support Services Ltd | Health & social care | 2020 |
| Stephen Shaw Transport Limited | Transport & logistics | 2014 |
| Stephensons Apartments Residents Association Limited | Households | 1995 |
| Steri Medical Consulting Ltd | Professional & scientific | 2024 |
| Steri Medical Holdings Limited | Professional & scientific | 2024 |
| Sterling Private Client Limited | Professional & scientific | 2019 |
| Sterling Realtors Ltd | Real estate | 2018 |
| Sterling Software Solutions (UK) Ltd | Information & communication | 2012 |
| Steve Broome Transport Limited | Transport & logistics | 2026 |
| Steve Hayes Ltd | Construction | 2016 |
| Steven Meredith Legal Services Limited | Professional & scientific | 2022 |
| Stevens Dream Homes Ltd | Real estate | 2025 |
| Sticky Education Ltd | Education | 2024 |
| Sticky Jims Limited | Wholesale & retail | 2009 |
| Sticky-Stuff Moto Online Ltd | Wholesale & retail | 2019 |
| Stiglom Ltd | Other services | 2019 |
| Stiperstone Analytics Limited | Mining & quarrying | 2019 |
| Stirchley Hall Management Company Limited | Households | 1996 |
| Stirchley Properties Limited | Real estate | 2015 |
| Stitchontime Ltd | Wholesale & retail | 2013 |
| STL Nail Spa Limited | Other services | 2024 |
| Stobbs & Co Limited | Professional & scientific | 2012 |
| Stocknix Ltd | Wholesale & retail | 2026 |
| Stockton Insulation Limited | Other services | 2019 |
| Stokey Plant Hire Limited | Mining & quarrying | 1983 |
| Stonatik Ltd | Other services | 2019 |
| Stonehurst Developments Limited | Real estate | 2006 |
| Stoneridge Holdings Ltd | Financial services | 2020 |
| Stoneyhill Limited | Real estate | 2002 |
| Stop N Stop Ltd | Other services | 2024 |
| Storebuilder Ltd | Information & communication | 2015 |
| Stove and Chimney Direct Ltd | Wholesale & retail | 2021 |
| Stovee Ltd | Other services | 2019 |
| Straden Ltd | Other services | 2019 |
| Strahlenburg Management Ltd | Financial services | 2014 |
| Strata Housing Services Limited | Construction | 2013 |
| Strategic Healthcare Planning (2025) Limited | Professional & scientific | 2025 |
| Strategic Healthcare Planning LLP | | 2010 |
| Strategic Medical Infrastructure Limited | Professional & scientific | 2023 |
| Stratford College of Business and Management Ltd | Education | 2010 |
| Stratos Shield Ltd | Professional & scientific | 2025 |
| Stratstone Holdings Ltd | Real estate | 2026 |
| Stratton Debt Associates Ltd | Professional & scientific | 2025 |
| Stratum Home Care Ltd | Public administration | 2022 |
| Streamliner Designs Limited | Extraterritorial | 2009 |
| Streda Ltd | Other services | 2020 |
| Street Tree Care & Landscaping Ltd | Administrative & support | 2023 |
| Stripemaster Limited | Administrative & support | 2002 |
| Strive Green Energy Centre Ltd | Construction | 2026 |
| Strothers Ltd | Real estate | 2021 |
| STS Property Investments Limited | Real estate | 2019 |
| Stuart Pace Legal Services Ltd | Administrative & support | 2017 |
| Stuart Wortley Limited | Professional & scientific | 2023 |
| Student Coaching Limited | Education | 2004 |
| Studini Limited | Transport & logistics | 2025 |
| Studio Evolution Limited | Professional & scientific | 2019 |
| Studio Nune Ltd | Professional & scientific | 2018 |
| STUDIO360 Creative Ltd | Professional & scientific | 2019 |
| Study Base Limited | Education | 2013 |
| Stufd. Ltd | Hospitality | 2026 |
| Styleway Properties Limited | Real estate | 2018 |
| SU Heera Limited | Wholesale & retail | 2021 |
| Suba and ANU Ltd | Real estate | 2023 |
| Subami Ltd | Other services | 2019 |
| Subous Ltd | Other services | 2020 |
| Substrate Associates Limited | Professional & scientific | 2015 |
| Suduva Ltd | Other services | 2020 |
| Sugar Stamp Ltd | Manufacturing | 2020 |
| Sugardice Ltd | Information & communication | 2024 |
| SUM 42 Consulting Limited | Professional & scientific | 2024 |
| Summerlife Limited | Manufacturing | 2017 |
| Sunglow Aesthetics Limited | Other services | 2017 |
| Sunil Bhatia Limited | Health & social care | 2014 |
| Sunlit Keys Ltd | Real estate | 2024 |
| Sunny Mews Management Company Limited | Households | 2010 |
| Sunrise Devine Homes Ltd | Real estate | 2022 |
| Sunshi Limited | Transport & logistics | 2026 |
| Sunshine Care and Support Services Ltd | Health & social care | 2025 |
| Super Duper Cars Ltd | Wholesale & retail | 2025 |
| Superb Food Limited | Hospitality | 2026 |
| Supercede Technology Ltd | Information & communication | 2016 |
| Superior Construction Shropshire Ltd | Construction | 2025 |
| Superior Interiors (Midlands) Ltd | Construction | 2014 |
| Supplyrite Limited | Wholesale & retail | 2002 |
| Supreme Conversions Ltd | Manufacturing | 2023 |
| Supreme Leisure Limited | Administrative & support | 2020 |
| Supremo Limited | Manufacturing | 2007 |