| Smart Groom Ltd | Administrative & support | 1998 |
| Smart Homes Estates Limited | Real estate | 2017 |
| Smart Lettings Ltd | Real estate | 2018 |
| Smart Process Limited | Information & communication | 2025 |
| Smart Prospects Ltd | Professional & scientific | 2013 |
| Smart Repairs West Midlands Limited | Wholesale & retail | 2023 |
| Smart Storage Spaces Ltd | Manufacturing | 2020 |
| Smartdelivery Limited | Transport & logistics | 2025 |
| Smarted-Itors Limited | Information & communication | 2011 |
| Smarttag Solutions Limited | Information & communication | 2026 |
| Smash World 1 Ltd | Hospitality | 2025 |
| Smashroom Music & Wellbeing CIC | Education | 2026 |
| SMH (Americas) Limited | Administrative & support | 2002 |
| SMI Manufacturing Limited | Professional & scientific | 2018 |
| Smile Crescent Ltd | Health & social care | 2018 |
| Smith & Lawrence Ltd | Professional & scientific | 2017 |
| Smith Locks Holdings Limited | Hospitality | 2025 |
| Smiths Garden Solutions Ltd | Administrative & support | 2020 |
| Smooth Accommodation Ltd | Real estate | 2019 |
| SMR Construction Limited | Construction | 2003 |
| SMR Developments Limited | Real estate | 1996 |
| SMR Retreats Limited | Real estate | 2025 |
| SMW Performance Ltd | Wholesale & retail | 2024 |
| Sneaker Hutt Ltd | Wholesale & retail | 2025 |
| SNL Interiors Limited | Manufacturing | 2020 |
| Snobs Aesthetics Ltd | Other services | 2021 |
| Snows Mini Limited | Wholesale & retail | 2025 |
| Soak Hardwood Flooring Limited | Construction | 2016 |
| Sobob Ltd | Other services | 2023 |
| Social Business Development Limited | Professional & scientific | 2013 |
| Social Care Consult Limited | Administrative & support | 2020 |
| Social Work Equity Network CIC | Education | 2026 |
| Socialite Ltd | Professional & scientific | 2026 |
| Sociedad Ltd | Other services | 2019 |
| Society Voice Foundation-Uk | Education | 2006 |
| Soeng Limited | Professional & scientific | 2006 |
| Sofa Outlet Ltd Ltd | Wholesale & retail | 2025 |
| Sofood! Limited | Manufacturing | 2013 |
| Softies Ltd | Other services | 2024 |
| SOL Energy Renewable Technologies Limited | Construction | 2016 |
| Solar Geeks Ltd | Construction | 2025 |
| Solar Inks Ltd | Manufacturing | 2004 |
| Solar O&M Consultancy Ltd | Professional & scientific | 2023 |
| Solarloft Limited | Construction | 2024 |
| Solarspect Ltd | Information & communication | 2023 |
| Solata Ltd | Health & social care | 2018 |
| Sole ET. AL Ltd | Wholesale & retail | 2016 |
| Sole ET. AL Raws Ltd | Wholesale & retail | 2023 |
| Solid Roofs Limited | Administrative & support | 2012 |
| Solid Steal Limited | Financial services | 2023 |
| Solidtrack Global Ltd | Wholesale & retail | 2019 |
| Solisco Ltd | Construction | 2016 |
| Solitaire European Limited | | 1986 |
| Solo Enterprise Ltd | Financial services | 2022 |
| Soloride Ltd | Transport & logistics | 2017 |
| Solum Assets Ltd | Professional & scientific | 2022 |
| Solution Entertainment Limited | Information & communication | 2008 |
| Solutions Box Ltd | Information & communication | 2025 |
| Solutions R US Ltd | Real estate | 2013 |
| Soluxe Studios Ltd | Wholesale & retail | 2025 |
| Solvr Force Limited | Professional & scientific | 2025 |
| Somatic Soundwave Healing Ltd | Health & social care | 2025 |
| Somatik Ltd | Administrative & support | 2019 |
| Somerwood Consulting Limited | Professional & scientific | 2024 |
| Somerwood Limited | Agriculture & fishing | 2019 |
| Songshijia Limited | Other services | 2018 |
| Sony's Shop Ltd | Extraterritorial | 2022 |
| Soon YI Takeaway Ltd | Hospitality | 2024 |
| Sophie's Beauty Treatments Limited | Other services | 2023 |
| Sorbo TEN Limited | Professional & scientific | 1908 |
| Sort Residents Limited | Households | 2005 |
| Soter H.R.M Limited | Professional & scientific | 2022 |
| Soul Create Limited | Administrative & support | 2021 |
| Soul Resuscitation Ltd | Wholesale & retail | 2015 |
| Sound Line Ltd | Other services | 2018 |
| Soundstage Events Limited | Information & communication | 1998 |
| Source a Property Ltd | Real estate | 2025 |
| Source Tickets Ltd | Wholesale & retail | 2019 |
| South END Hospitality Ltd | Real estate | 2025 |
| South Staffs Hire Limited | Administrative & support | 2005 |
| Southwater Developments Limited | Real estate | 2005 |
| Southwater Event Group Limited | Professional & scientific | 2004 |
| Southwater Hotel Limited | Hospitality | 2016 |
| Sovereign Elite Services Ltd | Professional & scientific | 2025 |
| Sozopol Ltd | Other services | 2020 |
| SP Finance Ltd | Financial services | 2017 |
| SP GAS and Plumbing (Telford) Ltd | Construction | 2018 |
| SP Hardware & Guttering Ltd | Wholesale & retail | 2020 |
| SP Legal Solutions Limited | Professional & scientific | 2015 |
| SP Property Rentals Ltd | Real estate | 2024 |
| SP Spa & Wellness Ltd | Professional & scientific | 2019 |
| Space to Home Limited | Professional & scientific | 2025 |
| Sparely Ltd | Wholesale & retail | 2023 |
| Sparkalle Limited | Information & communication | 2022 |
| Sparkle’S Car Wash Centre Limited | Other services | 2023 |
| Sparkling Healthcare Services Ltd | Administrative & support | 2021 |
| Sparkum Ltd | Other services | 2018 |
| Sparta Sales & Marketing (UK) Limited | Information & communication | 2018 |
| Spaull Dream Homes Ltd | Real estate | 2021 |
| Special Little Towns Ltd | Hospitality | 2025 |