| Sikh Motorcycle Club Midlands Ltd | Arts & recreation | 2026 |
| Silent OWL Trading Limited | Construction | 2014 |
| Silk Golf Ltd | Arts & recreation | 2026 |
| Silk Sharples Jennings Limited | Administrative & support | 2012 |
| Silky Clean Ltd | Administrative & support | 2025 |
| Silver Fish Fisheries Limited | Hospitality | 2019 |
| Silver Marbles Limited | Information & communication | 2010 |
| Simco Precision Limited | Manufacturing | 2014 |
| Simet Limited | Health & social care | 2022 |
| Simio Project Ltd | Construction | 2024 |
| Simmonds Transport Limited | Transport & logistics | 2001 |
| Simon Heart Ltd | Transport & logistics | 2019 |
| Simon Utilities Ltd | Construction | 2019 |
| Simpkins Bees Ltd | Agriculture & fishing | 2011 |
| Simply Green Limited | Extraterritorial | 2007 |
| Simply Perfect Hair Makeup & Training Academy Ltd | Other services | 2019 |
| Simply POD Limited | Wholesale & retail | 2015 |
| Simply Salon Supplies Ltd | Other services | 2013 |
| Simply Solar Limited | Extraterritorial | 2007 |
| Simply Submissions Ltd | Professional & scientific | 2025 |
| Simul Homes Ltd | Real estate | 2021 |
| Sincere Cleaning Ltd | Administrative & support | 2019 |
| Singh G Limited | Wholesale & retail | 2025 |
| Singh Kaur Sunner Ltd | Real estate | 2023 |
| Singhs Homes Ltd | Real estate | 2020 |
| Singla Properties Ltd | Real estate | 2019 |
| Single Service Ltd | Manufacturing | 2020 |
| SIP & Graze Ltd | Administrative & support | 2025 |
| SIS Telford Limited | Real estate | 2021 |
| Sisterhood Clothing Ltd | Other services | 2015 |
| Sitanos Brothers Olive & OIL Ltd | Manufacturing | 2025 |
| Site Visit Services Limited | Extraterritorial | 2018 |
| Sitlex Ltd | Other services | 2019 |
| Siwaspat Ltd | Other services | 2019 |
| SIX Bridges Investments Ltd | Real estate | 2020 |
| SIX Twelve Holdings Limited | Financial services | 2025 |
| Sixteen Taps Ltd | Hospitality | 2026 |
| Sizin Ltd | Administrative & support | 2020 |
| SJ & CS Services Limited | Professional & scientific | 2020 |
| SJ Advanced Healthcare Ltd | Health & social care | 2020 |
| SJ Spencer Consulting Ltd | Professional & scientific | 2025 |
| SJG Holdings Limited | Professional & scientific | 2000 |
| SJO Owens Properties Limited | Real estate | 2025 |
| SJP Bars Limited | Hospitality | 2024 |
| SJP Business Accountants Limited | Professional & scientific | 2020 |
| SJP Business Bookkeeping Limited | Professional & scientific | 2022 |
| SJP Business Consultancy Limited | Professional & scientific | 2022 |
| SJP Business Limited | Real estate | 2022 |
| SJP Inns & Dining Ltd | Hospitality | 2025 |
| SJP PUB Holdings Ltd | Hospitality | 2025 |
| Sjtb Limited | Information & communication | 2013 |
| SJU School Business Consultancy Ltd | Education | 2018 |
| Sjvr Ltd | Administrative & support | 2019 |
| SK Beauty Atelier Limited | Other services | 2024 |
| SK Living Spaces Ltd | Construction | 2026 |
| SK Safety Solutions Ltd | Construction | 2023 |
| Skaab Ltd | Real estate | 2026 |
| Skelly Accountancy Limited | Professional & scientific | 2013 |
| Skill Specialists Limited | Financial services | 2021 |
| Skilled Mapping Ltd | Professional & scientific | 2019 |
| Skillry Limited | Information & communication | 2024 |
| Skills & Techniques Limited | Education | 2005 |
| Skills Tuition Centre Limited | Education | 2022 |
| Skillselect Ltd | Construction | 2023 |
| Skip Hire UK Limited | Professional & scientific | 2018 |
| SKJ Transport & Logistics Ltd | Transport & logistics | 2023 |
| SKM Media Limited | Professional & scientific | 2026 |
| SKR Dynamics Ltd | Wholesale & retail | 2021 |
| Skunkworks IT Limited | Information & communication | 2021 |
| Skunkworks IT Services Limited | Information & communication | 2021 |
| Skunkworks Managed IT Services Ltd | Information & communication | 2019 |
| Skyblue IT Services Ltd | Information & communication | 2018 |
| Skye Care Shropshire Ltd | Health & social care | 2026 |
| Skylark Virtual Services Limited | Administrative & support | 2022 |
| Skylens Photography and Video Limited | Professional & scientific | 2017 |
| Skyline Horizons Properties Ltd | Real estate | 2025 |
| Skyrah Management and Services Ltd | Administrative & support | 2022 |
| SL Bodyworx Ltd | Wholesale & retail | 2026 |
| SLA Enterprises Limited | Professional & scientific | 2013 |
| SLC Automotive Company Limited | Wholesale & retail | 2024 |
| SLC Fire Services Ltd | Professional & scientific | 2018 |
| Sleey Limited | Health & social care | 2022 |
| Sleight Properties Ltd | Real estate | 2017 |
| Slices Wellington Ltd | Hospitality | 2016 |
| Slick Kutz Ltd | Other services | 2023 |
| Sljohnson Installations Ltd | Construction | 2026 |
| Sloan Construction Consultants Ltd | Professional & scientific | 2026 |
| Slovo Limited | Transport & logistics | 2023 |
| SLT Lettings Ltd | Real estate | 2021 |
| SLV Property Ltd | Hospitality | 2018 |
| Slwfitness Ltd | Arts & recreation | 2025 |
| Small Woods Association | Other services | 2000 |
| Small World Change Consulting Ltd | Professional & scientific | 2015 |
| Smallhill Furniture Co. Ltd | Wholesale & retail | 2021 |
| Smart 1 Handyman Ltd | Construction | 2026 |
| Smart Benefits Ltd | Professional & scientific | 2017 |
| Smart Choice Property Services Ltd | Construction | 2024 |
| Smart Choice Roofing Ltd | Construction | 2023 |
| Smart Comply Ltd | Professional & scientific | 2000 |
| Smart Ctrl Ltd | Construction | 2023 |