| Sapphire Crest Care Solutions Limited | Health & social care | 2025 |
| Sapphire Property Group Ltd. | Real estate | 2015 |
| Sapphireroom Aesthetics Ltd | Health & social care | 2023 |
| SAR Technical Services Limited | Information & communication | 2010 |
| Sarah a Baker Ltd | Wholesale & retail | 2026 |
| Sarbloh Property Holdings Ltd | Real estate | 2024 |
| Sartam Ltd | Wholesale & retail | 2019 |
| SAS Accessories Ltd | Other services | 2022 |
| SAT Trading Group Ltd | Financial services | 2025 |
| Sathrad Ltd | Health & social care | 2025 |
| Satsuma Solutions Limited | Information & communication | 2014 |
| SAU Hing Ltd | Hospitality | 2018 |
| Savage Supplements Ltd | Health & social care | 2025 |
| Savemylight International Ltd | Wholesale & retail | 2019 |
| Saver Express Convenience Store Ltd | Wholesale & retail | 2023 |
| Savoy Communications Ltd | Information & communication | 2015 |
| Sawarn Ltd | Extraterritorial | 2024 |
| Saweta Ltd | Other services | 2019 |
| SAX & Telford Consultants Ltd | Manufacturing | 2014 |
| Saziki Ltd | Wholesale & retail | 2019 |
| SB Holding International Ltd | Real estate | 2020 |
| SB Movers Limited | Transport & logistics | 2024 |
| SB Safety and Fire Solutions Ltd | Professional & scientific | 2017 |
| SB Stunts Ltd | Arts & recreation | 2025 |
| Sb-Independent Ltd | Arts & recreation | 2021 |
| SBR Estates Ltd | Construction | 2017 |
| Sbreeze Automotive Ltd | Wholesale & retail | 2026 |
| SC Matthews Vacuum Engineering Ltd | Manufacturing | 2026 |
| Scaffolding Services Shropshire Ltd | Administrative & support | 2025 |
| Scala Vetro Ltd | Manufacturing | 2011 |
| Scantech Limited | Administrative & support | 1997 |
| Scaring Birds Ltd | Manufacturing | 1992 |
| Scarton Law Limited | Administrative & support | 2023 |
| Scene Local Media Ltd | Administrative & support | 2011 |
| Scentsationbox Limited | Wholesale & retail | 2023 |
| Scg-Uk Ltd | Wholesale & retail | 2020 |
| Schneider Electric Buildings UK Limited | Professional & scientific | 1993 |
| Schneider Electric Controls UK Limited | Manufacturing | 1962 |
| Schneider Electric DC Trustees Limited | Financial services | 2010 |
| Schneider Electric Energy UK Limited | Extraterritorial | 2010 |
| Schneider Electric Invensys (UK) Limited | Professional & scientific | 2014 |
| Schneider Electric Invensys Holdings Limited | Professional & scientific | 2014 |
| Schneider Electric IT UK Ltd | Manufacturing | 1995 |
| Schneider Electric Systems UK Limited | Manufacturing | 1934 |
| Schneider Trustees (Esps) Limited | Professional & scientific | 2022 |
| Schneider Trustees Limited | Extraterritorial | 1907 |
| Schwalbe Tyres UK Limited | Wholesale & retail | 1982 |
| Science Lands Limited | Information & communication | 2017 |
| Science Tuition With Charlotte Limited | Education | 2026 |
| Scooters at the Railway LLP | | 2018 |
| Scorpio Systems Limited | Wholesale & retail | 1989 |
| Scott Jones Construction Ltd | Construction | 2022 |
| Scrubmission Ltd | Wholesale & retail | 2023 |
| Scuba UK Ltd | Arts & recreation | 2021 |
| SDB Psychology Limited | Health & social care | 2017 |
| SDB Real Estate Investments Ltd | Real estate | 2026 |
| SDD Transport Ltd | Transport & logistics | 2018 |
| SDM Housing & Developments Ltd | Construction | 2019 |
| SDS Carpets Limited | Manufacturing | 2009 |
| SDT Electrical Contractors Limited | Manufacturing | 2003 |
| SDT Telecom Engineering Services Ltd | Information & communication | 2025 |
| SDW Gardening Ltd | Administrative & support | 2021 |
| SE Datacomms Ltd | Construction | 2026 |
| Sea Roots Ltd | Wholesale & retail | 2025 |
| Seachange ABI Ltd | Professional & scientific | 2013 |
| Seadragon Holdings Limited | Financial services | 2021 |
| Seagrave IT Consulting Ltd | Information & communication | 2020 |
| Seah Group Ltd | Financial services | 2025 |
| Seah Ltd | Administrative & support | 2016 |
| Sealparts Ltd | Wholesale & retail | 1980 |
| Seals and Components Limited | Wholesale & retail | 1990 |
| Seaside Holiday Lettings Ltd | Real estate | 2020 |
| Seaton Sports Limited | Wholesale & retail | 1985 |
| Secal Assembly and Supply Limited | Manufacturing | 2019 |
| Secal Sheet Metal (Midlands) Limited | Manufacturing | 1993 |
| Secret Weekend Ltd | Arts & recreation | 2023 |
| Secure Compliance Limited | Professional & scientific | 2004 |
| Secure Your Trips Limited | Administrative & support | 2021 |
| Secureforit Ltd | Information & communication | 2023 |
| Securepress Ltd | Information & communication | 2021 |
| Securerail Communications Ltd | Transport & logistics | 2026 |
| Security Cleared Consultants Ltd | Information & communication | 2014 |
| SED Electrical Products Limited | Wholesale & retail | 2018 |
| Sedgley Vulcanising Limited | Manufacturing | 2010 |
| Sedna Limited | Information & communication | 2025 |
| Seel Street Hospitality Ltd | Real estate | 2024 |
| Sehmbi House Renovation Ltd | Construction | 2025 |
| Seif Cars Ltd | Wholesale & retail | 2019 |
| Select Legal Services (Greece) Limited | Extraterritorial | 2024 |
| Selene Origins Ltd | Wholesale & retail | 2023 |
| Sell My Property Portfolio Ltd | Real estate | 2015 |
| Seller Success Ltd | Wholesale & retail | 2025 |
| Sellwego Limited | Wholesale & retail | 2023 |
| Semisaq Ltd | Other services | 2019 |
| Senate Limited | Professional & scientific | 2024 |
| SEND8 Properties Ltd | Real estate | 2017 |
| Senex Garden Solutions Limited | Wholesale & retail | 2023 |
| Senfriend Ltd | Wholesale & retail | 2024 |
| Seniorem Ltd | Professional & scientific | 2018 |
| Senoplast (UK) Limited | Extraterritorial | 1984 |