| Sensar Ltd | Extraterritorial | 2014 |
| Sensational Journeys CIC | Health & social care | 2025 |
| Sensifot Ltd | Other services | 2019 |
| Sentinel Auto Keys Ltd | Wholesale & retail | 2026 |
| Sephiroth Investments Ltd | Real estate | 2020 |
| Serchem Holdings Limited | Financial services | 2022 |
| Serchem Limited | Manufacturing | 1981 |
| Serck Controls Limited | Manufacturing | 2002 |
| Serck Industries Limited | Professional & scientific | 1959 |
| Seremora Ltd | Wholesale & retail | 2022 |
| Serendipity Happens Ltd | Administrative & support | 2017 |
| Serene 01 Limited | Health & social care | 2016 |
| Serene Accountancy Limited | Professional & scientific | 2026 |
| Serene Dental Ltd | Health & social care | 2024 |
| Sergipe Ltd | Other services | 2022 |
| Serifon Limited | Administrative & support | 2018 |
| Serve Medical Limited | Financial services | 2025 |
| Servepro Services Limited | Information & communication | 2013 |
| Servepro Software Ltd | Information & communication | 2024 |
| Servesport Limited | Administrative & support | 2009 |
| Servette Ltd | Administrative & support | 2020 |
| Sessional MED Ltd | Health & social care | 2021 |
| Sethirtyeight Limited | Information & communication | 2016 |
| Seton Ltd | Administrative & support | 2019 |
| Setsgrove Holdings Limited | Real estate | 1954 |
| Seven House Ltd | Real estate | 2026 |
| Seven Stars Cuisine Limited | Hospitality | 2015 |
| Seven Stays Telford Ltd | Hospitality | 2025 |
| SEVENTY9 Consulting Ltd | Information & communication | 2023 |
| Severn Bank Investments Limited | Financial services | 2008 |
| Severn Cleaning Solutions Ltd | Administrative & support | 2026 |
| Severn Commercials Ltd | Real estate | 2023 |
| Severn Financial Training Ltd | Education | 2013 |
| Severn Gorge Countryside Services Limited | Administrative & support | 2026 |
| Severn Gorge Countryside Trust | Agriculture & fishing | 1991 |
| Severn Investment Limited | Financial services | 2021 |
| Severn Management Ltd | Professional & scientific | 2022 |
| Severn Oak Construction Limited | Construction | 2021 |
| Severn Optical Limited | Manufacturing | 2014 |
| Severn Restaurant Ltd | Hospitality | 2026 |
| Severn Valley Installation Services Limited | Construction | 2024 |
| Severn Valley Motorsport Ltd | Wholesale & retail | 2018 |
| Severn Volts Limited | Construction | 2023 |
| Seymour Industrial Limited | Information & communication | 2022 |
| Seymour Manufacturing International Limited | Wholesale & retail | 1988 |
| Seymour, Seymour & SON Limited | Professional & scientific | 1998 |
| SFA1877 Enterprises Limited | Arts & recreation | 2025 |
| Sfintul Ltd | Other services | 2020 |
| Sfmar Transport Ltd | Transport & logistics | 2018 |
| SG Aesthetics Ltd | Health & social care | 2017 |
| SG Car Investments Limited | Financial services | 2025 |
| SG for Business Limited | Professional & scientific | 2019 |
| SGB Bar Investments Limited | Financial services | 2025 |
| SGC Automation Ltd | Professional & scientific | 2025 |
| SGE Developments Ltd | Wholesale & retail | 2018 |
| SGS Speciality Foods Ltd | Wholesale & retail | 2020 |
| SHA Car Sales Ltd | Wholesale & retail | 2025 |
| SHA Vehicle Sales & Service Ltd | Wholesale & retail | 2026 |
| Shades & Fades Ltd | Other services | 2024 |
| Shades of Fleetwood Limited | Extraterritorial | 2022 |
| Shahab Spices Ltd | Hospitality | 2017 |
| Shahnaz Locums Limited | Health & social care | 2015 |
| Shakespeare Industrial Supplies Limited | Wholesale & retail | 2015 |
| Shane Kelly Racing Limited | Arts & recreation | 2015 |
| Shanghai Star Ltd | Hospitality | 2014 |
| Sharon Griffin Art Ltd | Education | 2023 |
| Shaw Circuits Ltd | Manufacturing | 2012 |
| Shaw Circuits Midlands Ltd | Construction | 2026 |
| Shawbirch DP Ltd | Health & social care | 2021 |
| Shawbirch Medical Health Practice Limited | Real estate | 2019 |
| Shawbury UTD Community Sports and Recreational Centre CIC | Arts & recreation | 2019 |
| Shawfield Group Limited | Extraterritorial | 2018 |
| Shawthorpe Recruitment Limited | Administrative & support | 2019 |
| Shay Limited | Professional & scientific | 2018 |
| Shebdon Crane Hire Limited | Administrative & support | 2001 |
| Shed Box Limited | Construction | 2025 |
| Shed City Limited | Manufacturing | 1996 |
| Sheds NOW Ltd | Extraterritorial | 2016 |
| Sheeran Kingsley Properties Ltd | Real estate | 2025 |
| Shepherd Cleaning Services Ltd | Extraterritorial | 2024 |
| Shield Properties Group Limited | Financial services | 2024 |
| Shifnal & Albrighton Funeral Services Limited | Extraterritorial | 2012 |
| Shinepro Ltd | Administrative & support | 2024 |
| Shire Property Group Limited | Real estate | 2019 |
| Shire Windows Limited | Construction | 2022 |
| Shiregate Property Holdings Ltd | Households | 2026 |
| Shireluxe Shutters Ltd | Wholesale & retail | 2026 |
| Shires Property Management Ltd | Households | 2023 |
| Shop Candella Limited | Wholesale & retail | 2025 |
| Shop Locally Telford Ltd | Wholesale & retail | 2018 |
| Shorrock Trichem Limited | Manufacturing | 2001 |
| Shortbakes Ltd | Wholesale & retail | 2026 |
| Shott Properties Limited | Real estate | 2017 |
| Show Systems Marquees Ltd | Construction | 2015 |
| Shpi Holdings Limited | Financial services | 2014 |
| Shrayhill Investment (Telford) Limited | Real estate | 2020 |
| Shree Sukhram Associates Limited | Information & communication | 2014 |
| Shrewsbury Airsoft Supplies Ltd | Wholesale & retail | 2022 |
| Shrewsbury Lettings Ltd | Real estate | 2019 |
| Shrewsbury Soda Club CIC | Education | 2026 |