| S E Motors Ltd | Wholesale & retail | 2016 |
| S G Services (Shropshire) Ltd | Construction | 2013 |
| S H Roofing Telford Ltd | Construction | 2022 |
| S J Hughes Installation Limited | Construction | 2014 |
| S Kerr Electrical Limited | Energy | 2026 |
| S L K Decorators Ltd | Construction | 2013 |
| S M Landscaping (2021) Limited | Other services | 2021 |
| S P Auto Repairs Ltd | Wholesale & retail | 2024 |
| S P E Selection Ltd | Administrative & support | 2012 |
| S P Minton Ltd | Construction | 2019 |
| S P Plasterers Ltd | Construction | 2022 |
| S Payne Services Ltd | Professional & scientific | 2024 |
| S S Bhakar Enterprise Ltd | Real estate | 2018 |
| S S G Investments Holdings Limited | Financial services | 2016 |
| S S G Projects Limited | Extraterritorial | 2012 |
| S S G Quarries Limited | Professional & scientific | 2007 |
| S T Services (Shropshire) Limited | Transport & logistics | 2010 |
| S V Taylor Digestate Ltd | Water & waste | 2017 |
| S V Taylor Ltd | Agriculture & fishing | 2011 |
| S&A (Telford) Ltd | Hospitality | 2025 |
| S&A Hub Ltd | Administrative & support | 2025 |
| S&J Gill Ltd | Wholesale & retail | 2025 |
| S&T Commerce Ltd | Wholesale & retail | 2023 |
| S. L. Corse Limited | Wholesale & retail | 1999 |
| S.B.Howard Limited | Professional & scientific | 2017 |
| S.D.Walker Limited | Professional & scientific | 2023 |
| S.E.S. Associates Ltd | Professional & scientific | 2002 |
| S.E.S. Sterling Limited | Manufacturing | 1968 |
| S.English Equine Ltd | Arts & recreation | 2024 |
| S.I.M. (Vehicle Consultancy) Limited | Wholesale & retail | 2001 |
| S.T Milner Developments Ltd | Households | 2022 |
| S.T. Auto Sales Limited | Wholesale & retail | 2020 |
| S.T.E Plumbing & Heating Ltd | Construction | 2024 |
| S.Zaktrader Ltd | Wholesale & retail | 2022 |
| S1BED Ltd | Construction | 2023 |
| SA Tree Surgery Ltd | Agriculture & fishing | 2026 |
| Sabar Investment Group Ltd | Real estate | 2024 |
| Sabis Curtains Ltd | Wholesale & retail | 2023 |
| Sacyab Property Ltd | Real estate | 2022 |
| Safe and Sound Shropshire Ltd | Construction | 2025 |
| Safe Hands Traffic Management Ltd | Public administration | 2021 |
| Safe Hands Training Limited | Education | 2020 |
| Safe Line Recovery Ltd | Transport & logistics | 2025 |
| Safedrive Auto Centre Ltd | Wholesale & retail | 2023 |
| Safenet Security Ltd | Construction | 2023 |
| SAFFRON55 Limited | Information & communication | 2011 |
| Saftek Friction Limited | Manufacturing | 2017 |
| Sahib Bains Transport Ltd | Transport & logistics | 2025 |
| SAHO25 Limited | Hospitality | 2025 |
| Sahota.P.I Ltd | Real estate | 2026 |
| SAI Installations Ltd | Construction | 2021 |
| Saintly Skincare Ltd | Other services | 2022 |
| Sairen Books Limited | Manufacturing | 2026 |
| Sait Motorsport Limited | Arts & recreation | 2015 |
| Sajjan Media Ltd | Other services | 2022 |
| SAK Hospitality Ltd | Hospitality | 2026 |
| Sakaura Ltd | Administrative & support | 2023 |
| Sakre Homes Limited | Real estate | 2022 |
| Salham Properties Limited | Real estate | 2016 |
| Salisbury's Coatings and Blasting Services Ltd | Construction | 2025 |
| Salon Supplies - Stafford Ltd | Wholesale & retail | 2023 |
| Salon Supplies Telford Limited | Wholesale & retail | 2021 |
| Salonna Holdings Limited | Wholesale & retail | 2024 |
| Salop Antiques Ltd | Wholesale & retail | 2026 |
| Salop Drain Services Ltd | Administrative & support | 2019 |
| Salop Health Ltd | Professional & scientific | 2025 |
| Salop Sand & Gravel Holdings Limited | Financial services | 2020 |
| Salop Sand and Gravel Limited | Mining & quarrying | 2021 |
| Salop Sand Projects Limited | Extraterritorial | 2012 |
| Salop Security and Transport Services Ltd | Administrative & support | 2025 |
| Salopian Health & Safety Limited | Professional & scientific | 2016 |
| Salopwood Timber Frames Ltd | Construction | 2023 |
| Sals Forever Flowers Limited | Arts & recreation | 2021 |
| Salta Projects Limited | Professional & scientific | 2025 |
| Salty Rigging Ltd | Professional & scientific | 2023 |
| SAM Gwilt Limited | Professional & scientific | 2021 |
| Samara Sound Therapy Ltd | Health & social care | 2026 |
| Samatin Ltd | Wholesale & retail | 2019 |
| Same Old Store Ltd | Wholesale & retail | 2020 |
| Samento Ltd | Administrative & support | 2018 |
| Samitta Ltd | Wholesale & retail | 2019 |
| Samos Acquisition Company Limited | Financial services | 2013 |
| Samsons Plumbing & Heating Limited | Construction | 2016 |
| Samuchov Ltd | Wholesale & retail | 2021 |
| Samuel Telford Ltd | Financial services | 2021 |
| Samuels of Shropshire Limited | Wholesale & retail | 2013 |
| Sanctuary Keepers CIC | Health & social care | 2024 |
| Sander Jurkiewicz Limited | Professional & scientific | 2013 |
| Sanderslettings Ltd | Real estate | 2023 |
| Sandhu Transport & Logistics Ltd | Transport & logistics | 2025 |
| Sandi & Sons Ltd | Real estate | 2019 |
| Sandnes Ltd | Other services | 2019 |
| Sandycroft Property Services Ltd | Real estate | 2025 |
| Sangha Sweets & Snacks Ltd | Hospitality | 2020 |
| Sanghera Homes Ltd. | Financial services | 2002 |
| Sanita UK Limited | Wholesale & retail | 1999 |
| Sankofa Welcome Home Tours Ltd | Administrative & support | 2025 |
| Santorini TAN Limited | Wholesale & retail | 2025 |
| Santos & Santana Ltd | Extraterritorial | 2022 |
| Sapnakaur Limited | Health & social care | 2015 |