| Somerset Levels Aircraft Engineering Ltd | Professional & scientific | 2012 |
| Somerset Litigation Limited | Professional & scientific | 2018 |
| Somerset Lodges Limited | Hospitality | 2022 |
| Somerset Medical Services Limited | Health & social care | 2012 |
| Somerset Motorhome Centre Limited | Wholesale & retail | 2005 |
| Somerset Play Forum | Arts & recreation | 2006 |
| Somerset Plumbing Services Limited | Construction | 2012 |
| Somerset Precision Tiling Limited | Construction | 2020 |
| Somerset Projects Limited | Real estate | 2023 |
| Somerset Range Cooker Services Ltd | Construction | 2025 |
| Somerset RC TRI Ltd | Arts & recreation | 2015 |
| Somerset Reservoir Simulation Services Ltd | Professional & scientific | 2017 |
| Somerset Safety Ltd | Professional & scientific | 2010 |
| Somerset Sight Limited | Health & social care | 2013 |
| Somerset Spring Water Limited | Extraterritorial | 2006 |
| Somerset Stoves (SW) Ltd | Wholesale & retail | 2025 |
| Somerset Technology Services Limited | Information & communication | 1999 |
| Somerset Timber Services Ltd | Agriculture & fishing | 2013 |
| Somerset Tyres and Services Ltd | Wholesale & retail | 2025 |
| Somerset Web Design Limited | Information & communication | 2008 |
| Somerset Web Services Ltd | Information & communication | 2014 |
| Somerset Wildlife Trust | Administrative & support | 1964 |
| Somerset Wood Flooring Ltd | Wholesale & retail | 2026 |
| Somerton Court Management Company Limited | Households | 2002 |
| Somerton Kitchens Ltd | Manufacturing | 2015 |
| Somerton Music and Arts Festival Community Interest Company | Arts & recreation | 1987 |
| Somerton RFC Limited | Arts & recreation | 2015 |
| Somnium Music Group Limited | Arts & recreation | 2024 |
| Sonder Digital Limited | Information & communication | 2010 |
| Sonoma Dental Ltd | Professional & scientific | 2025 |
| Sonoray Ltd | Health & social care | 2025 |
| Sooty Productions Ltd | Extraterritorial | 2021 |
| Sopertech Ltd | Real estate | 2018 |
| Sophisticaf Ltd | Hospitality | 2024 |
| Sophisticatered Ltd | Hospitality | 2023 |
| Sopp (UK) Limited | Wholesale & retail | 2002 |
| Sorella Collective Ltd | Other services | 2025 |
| South Petherton Majorettes Limited | Arts & recreation | 2023 |
| South Road Watchet Management Company Limited | Households | 2000 |
| South Street Motors AVR Limited | Wholesale & retail | 2012 |
| South Street Motors Investments Limited | Real estate | 2017 |
| South Street Motors Limited | Wholesale & retail | 2000 |
| South View Advisory Limited | Professional & scientific | 2024 |
| South West (SW) Brokers Limited | Financial services | 2026 |
| South West Aerial Surveys Ltd | Construction | 2020 |
| South West Agriculture Limited | Agriculture & fishing | 2010 |
| South West Association of Training Providers Limited | Education | 2010 |
| South West Audit Partnership Limited | Professional & scientific | 2012 |
| South West Automation & Control Limited | Professional & scientific | 2021 |
| South West Bricklayers Limited | Construction | 2015 |
| South West BUS and Coach Glazing Limited | Wholesale & retail | 2020 |
| South West Business Connections Limited | Information & communication | 2013 |
| South West Cabling Contractors Ltd | Construction | 2025 |
| South West Clinical Dermatology Ltd | Health & social care | 2020 |
| South West Dies Limited | Manufacturing | 1997 |
| South West Distribution Limited | Wholesale & retail | 2023 |
| South West Equine Services Ltd | Agriculture & fishing | 2025 |
| South West GAS Services Limited | Construction | 2016 |
| South West Head and Neck Surgery Ltd | Health & social care | 2017 |
| South West Heritage Trust Trading Limited | Arts & recreation | 2014 |
| South West Hoof Trimming Ltd | Agriculture & fishing | 2016 |
| South West Inflatables Ltd | Arts & recreation | 2021 |
| South West Integrated Risk Solutions Limited | Professional & scientific | 2024 |
| South West Interventional Radiology Ltd | Health & social care | 2025 |
| South West Laundry (Albion) Limited | Other services | 2026 |
| South West Martial Arts Ltd | Arts & recreation | 2009 |
| South West Organic Milk Limited | Wholesale & retail | 2022 |
| South West Overhead Services Limited | Construction | 2015 |
| South West Partnerships Limited | Manufacturing | 2011 |
| South West Peninsular Training Limited | Professional & scientific | 1998 |
| South West Properties (Taunton) Limited | Construction | 2018 |
| South West Property Reports Ltd | Professional & scientific | 2007 |
| South West Sleep Clinic Limited | Health & social care | 2010 |
| South West Sporting Limited | Arts & recreation | 2019 |
| South West UK Lettings Limited | Hospitality | 2025 |
| South Western Property Developments Limited | Real estate | 2007 |
| South-West Roofing (SW) Ltd | Construction | 2026 |
| South-West Spinal Surgery Ltd | Health & social care | 2011 |
| Southend Carers | Health & social care | 2001 |
| Southern Agri Ltd | Agriculture & fishing | 2025 |
| Southern Engineering Equipment Limited | Wholesale & retail | 2016 |
| Southern Hydrogen Ltd | Energy | 2020 |
| Southern Sinfonia | Arts & recreation | 2005 |
| Southern Tractors (Somerset) Limited | Wholesale & retail | 2007 |
| Southmead Bodyworks Ltd | Wholesale & retail | 2020 |
| Southwater Veterinary Group Limited | Professional & scientific | 2021 |
| Southwest Care-Line Ltd. | Health & social care | 2022 |
| Southwest Disciplined Canine Limited | Other services | 2022 |
| Southwest Environmental Limited | Administrative & support | 2009 |
| Southwest Laundry (Wessex) Limited | Other services | 2017 |
| Southwest Motorhomes Sales, Hire and Services Limited | Wholesale & retail | 2011 |
| Southwest Pathology Services LLP | | 2011 |
| Southwest Supreme Cleaning Services Limited | Administrative & support | 2019 |
| Southwestroofworks Ltd | Construction | 2025 |
| Souvenir Events Limited | Arts & recreation | 2025 |
| Sovereign Interior Projects Limited | Construction | 2011 |
| Sowdropship Ltd | Wholesale & retail | 2022 |
| SOX Bramble Ltd | Professional & scientific | 2018 |
| Spacial Awareness Limited | Construction | 2020 |
| Sparks Clothing & Living Ltd | Wholesale & retail | 2014 |