| Sparks Life Limited | Wholesale & retail | 2026 |
| Spartan Consultancy UK Ltd | Administrative & support | 2024 |
| Spartan Recovery Limited | Health & social care | 2026 |
| Spatia Real Estate Limited | Construction | 2020 |
| Specialist Broking Retail Limited | Financial services | 2016 |
| Specialist Refinishing Services Ltd | Manufacturing | 2021 |
| Specpath Limited | Health & social care | 2009 |
| Spectrum Sales & Marketing Limited | Hospitality | 2004 |
| Spence Robert Pethick Ltd | Professional & scientific | 2014 |
| Spencer Coaching and Mentoring Limited | Professional & scientific | 2023 |
| Sperring and Sons Building Services Ltd | Construction | 2021 |
| SPH Retail Limited | Wholesale & retail | 2013 |
| Spiceland Limited | Real estate | 1997 |
| Spidercorp Limited | Information & communication | 2019 |
| Spidling Productions Limited | Information & communication | 2021 |
| Spiller & Webber Limited | Extraterritorial | 2010 |
| Spinal Cord Injury Case Management Limited | Health & social care | 2019 |
| Spinme Limited | Professional & scientific | 2004 |
| Spit and Sawdust Holdings Limited | Financial services | 2017 |
| SPL Properties (Crewkerne) Limited | Real estate | 2003 |
| Splash OR Cash Golf Ltd | Arts & recreation | 2025 |
| Splott Farm Camping Ltd | Extraterritorial | 2021 |
| Spotless Commercial & Domestic Cleaning Limited | Administrative & support | 2014 |
| Spotless Mobile Valeting (SW) Ltd | Administrative & support | 2014 |
| Spotless TOO, the Cleaning Company Limited | Administrative & support | 2016 |
| Spotless, the Cleaning Company Limited | Administrative & support | 2015 |
| Spring Business Consulting Limited | Agriculture & fishing | 2012 |
| Spring Hydrogen Limited | Professional & scientific | 2025 |
| Springboards Limited | Administrative & support | 2007 |
| Springbok Locum Ltd | Professional & scientific | 2023 |
| Springfield (Merriott) Management Company Limited | Households | 2020 |
| Springfields (GM) Ltd | Wholesale & retail | 2018 |
| Springly Limited | Financial services | 2018 |
| Sprut Technology (UK) Limited | Information & communication | 2003 |
| SPS Facilities LLP | | 2015 |
| SPX Electrical Contractors Limited | Construction | 2024 |
| Square Acre Holdings Limited | Real estate | 2021 |
| Squire Biggs Law Limited | Professional & scientific | 2019 |
| Squmon Ltd | Real estate | 2018 |
| SR Dental Solutions Ltd | Health & social care | 2022 |
| SR Ecommerce Ltd | Wholesale & retail | 2024 |
| SR Electrical (South West) Limited | Administrative & support | 2006 |
| SR Happy Smiles Ltd | Health & social care | 2026 |
| SR Info Solutions Ltd | Information & communication | 2013 |
| SR Properties Ltd | Construction | 2024 |
| SRD Technology UK Ltd | Information & communication | 2014 |
| SRJ & Sons Estate Holdings Ltd | Real estate | 2021 |
| SRJ Property Consultancy Ltd | Real estate | 2022 |
| SRK Capital Heights Ltd | Hospitality | 2024 |
| SRK Capital Ventures Ltd | Information & communication | 2025 |
| SRM Carver and SON Limited | Water & waste | 2017 |
| SRP (Taunton) Limited | Professional & scientific | 2005 |
| SRT Signature House Limited | Construction | 2010 |
| SSG Cars Ltd | Wholesale & retail | 1982 |
| SSJ Technical Services Ltd | Information & communication | 2015 |
| Sspdiggers Ltd | Administrative & support | 2022 |
| SSR Ventures Ltd | Hospitality | 2026 |
| Sssaam Ltd | Other services | 2024 |
| ST Andrew's View (Taunton) Management Limited | Households | 2004 |
| ST Antony's Management Company Limited | Households | 1998 |
| ST Aubyns Park Limited | Construction | 2021 |
| ST Elite Services Limited | Health & social care | 2019 |
| ST Georges (2002) Management Company NO 1 Limited | Administrative & support | 2002 |
| ST Georges (2002) Management Company NO 2 Limited | Administrative & support | 2002 |
| ST Georges (2002) Management Company NO 3 Limited | Administrative & support | 2002 |
| ST Georges (2002) Management Company NO 4 Limited | Administrative & support | 2002 |
| ST Giles Animal Centre Limited | Professional & scientific | 2017 |
| ST Giles Animal Welfare Ltd | Other services | 2023 |
| ST James' Properties (Taunton) Limited | Real estate | 1999 |
| ST John's Court Management Company (Wells) Limited | Households | 1982 |
| ST Katherines Close Management Company Limited | Households | 2024 |
| ST Margaret's Somerset Hospice Retail Limited | Wholesale & retail | 2010 |
| ST Mary's Green Management Company Limited | Households | 2023 |
| ST Mary's View (Beaminster) Management Company Limited | Households | 2019 |
| ST Pauls Dental Practice Ltd | Health & social care | 2009 |
| ST. Andrews (Freehold) Limited | Households | 1992 |
| ST. Andrews Court (Wells) Residents Association Limited | Households | 1979 |
| ST. Georges Hall (Glastonbury) Management Company Limited | Households | 1987 |
| ST. James' Gate (Somerset) Management Limited | Households | 2016 |
| ST. Johns Physiotherapy Practice Ltd | Health & social care | 2002 |
| ST. Margaret's Somerset Hospice | Health & social care | 1980 |
| ST. Thomas Court Limited | Households | 1979 |
| St.Audries Garages Limited | Real estate | 1962 |
| Stability Partners Ltd | Information & communication | 2026 |
| Stable Ceramics Limited | Health & social care | 2019 |
| Stable Court (Bicknoller) Management Company Limited | Real estate | 2025 |
| Stablesoft-Europe Limited | Construction | 2009 |
| Stacey Construction Limited | Construction | 2019 |
| Stafford House Secretarial Services Limited | Professional & scientific | 2005 |
| Stag Decking and Landscapes Ltd | Administrative & support | 2025 |
| Stag Environmental Ltd | Wholesale & retail | 2008 |
| Stag Vehicle Solutions Limited | Administrative & support | 2023 |
| Stags 1874 Limited | Real estate | 2010 |
| Standish Court (Taunton) Management Limited | Households | 2005 |
| Stanhurst Consulting Limited | Professional & scientific | 2019 |
| Stanley J Murphy Glazing Solutions Ltd | Construction | 2019 |
| Stanoli Ltd | Hospitality | 2018 |
| Stantonbury Holdings Limited | Administrative & support | 2017 |
| Staple Farm Enterprises Limited | Agriculture & fishing | 2025 |
| Staple Hill Shoot Ltd | | 2016 |