| Sleep Ventures Limited | Professional & scientific | 2013 |
| SLEEPS12 Limited | Real estate | 2005 |
| Sloan Properties Limited | Financial services | 2021 |
| Small Cars 4 ALL Ltd | Wholesale & retail | 2019 |
| Small Claims Portal Limited | Information & communication | 2015 |
| Small Matters Limited | Real estate | 2011 |
| Smart Communities Ltd | Professional & scientific | 2018 |
| Smart DEV Ltd | Agriculture & fishing | 2015 |
| Smart Global Solutions Limited | Information & communication | 2008 |
| Smart Play Toys Ltd | Extraterritorial | 2023 |
| Smart Software Engineering Limited | Information & communication | 2013 |
| Smart Vision Electrical Ltd | Construction | 2017 |
| Smart-Tek Electrical Services Limited | Wholesale & retail | 2009 |
| Smartblood Ltd | Health & social care | 2017 |
| Smarties Training Limited | Education | 2021 |
| Smig Services Limited | Wholesale & retail | 2020 |
| Smile Dental Group Limited | Extraterritorial | 2010 |
| Smith Mackley Ltd | Professional & scientific | 2009 |
| Smith Planning & Design Limited | Professional & scientific | 2003 |
| Smithkin Baker Ltd | Information & communication | 2018 |
| Smlp Holdings Ltd | Real estate | 2018 |
| Smoked Grill Co Ltd | Hospitality | 2026 |
| SMRM0126 Ltd | Construction | 2026 |
| Smsj Properties Ltd | Real estate | 2025 |
| Smyth Property Limited | Real estate | 2021 |
| Snapfish UK, Ltd. | Wholesale & retail | 2015 |
| Snaveneb Limited | Arts & recreation | 2019 |
| Sneyd Consultancy Ltd | Professional & scientific | 2024 |
| Snook (South West) Limited | Professional & scientific | 2017 |
| Snowball Future Limited | Financial services | 2011 |
| Snowberry Court Management Company Limited | Households | 2003 |
| Snowbusiness Hospitality Ltd | Hospitality | 2022 |
| SNS Business Partners Limited | Professional & scientific | 2022 |
| Social Marketing Doctors LLP | | 2018 |
| Society of Local Council Clerks | Other services | 2017 |
| Sodbury Book Garden Ltd | Wholesale & retail | 2024 |
| Sodbury Property Consultancy Limited | Administrative & support | 2021 |
| Sofane Holding Limited | Information & communication | 2011 |
| Sofane Netherlands Limited | Information & communication | 2011 |
| Softconiq Ltd | Information & communication | 2026 |
| Software Perimeters Ltd | Information & communication | 2012 |
| Soilconsult LLP | | 2012 |
| Solar Electrical Services Ltd | Construction | 2020 |
| Solardarity Ltd | Other services | 2017 |
| Solargain Ltd | Construction | 2022 |
| Solas Property and Land Ltd | Real estate | 2022 |
| Solid IT Ltd | Information & communication | 2018 |
| Soliis Ltd | Information & communication | 2025 |
| Solitarius Ltd | Wholesale & retail | 2015 |
| Solo Assets Ltd | Wholesale & retail | 2024 |
| Solo Business Solutions Ltd | Professional & scientific | 2024 |
| Solomon Family Investments Ltd | Financial services | 2025 |
| Solomon Mebratu Consultancy Limited | Administrative & support | 2025 |
| Soluna Health Ltd | Financial services | 2025 |
| Solutions (Worldwide) Limited | Transport & logistics | 1993 |
| Solutions Recruitment Limited | Administrative & support | 2001 |
| Somarton Limited | Wholesale & retail | 2013 |
| Somercourt Homes Limited | Real estate | 2002 |
| Somerset Adventures Ltd | Arts & recreation | 2020 |
| Somerset Air Conditioning Ltd | Energy | 2025 |
| Somerset and West Country Stairlifts Limited | Wholesale & retail | 1996 |
| Somerset Arts Business Cultural Alliance CIC | Administrative & support | 2019 |
| Somerset Bonsai Ltd | Wholesale & retail | 2026 |
| Somerset Build Expert Limited | Construction | 2026 |
| Somerset Campervan Company Ltd | Manufacturing | 2021 |
| Somerset Care at Home Limited | Health & social care | 1991 |
| Somerset Care Limited | Health & social care | 1990 |
| Somerset Care Support Services Limited | Health & social care | 2011 |
| Somerset Catering Ltd | Hospitality | 2023 |
| Somerset Chapel Limited | Real estate | 1995 |
| Somerset Chocolate Co Limited | Manufacturing | 2022 |
| Somerset Christmas Ltd | Wholesale & retail | 2022 |
| Somerset Claims Ltd | Professional & scientific | 2024 |
| Somerset Classic Motorcycles Ltd | Wholesale & retail | 2018 |
| Somerset Climate Control Ltd | Construction | 2023 |
| Somerset Co-Operative Services CIC | Professional & scientific | 2006 |
| Somerset Company Group Ltd | Wholesale & retail | 2018 |
| Somerset Computer Consultancy Limited | Information & communication | 1986 |
| Somerset Counselling Centre | Health & social care | 1994 |
| Somerset County Sports Ltd | Wholesale & retail | 2005 |
| Somerset Craft Limited | Wholesale & retail | 2018 |
| Somerset Cricket Foundation | Arts & recreation | 2010 |
| Somerset Electrical and Property Services Ltd | Construction | 2016 |
| Somerset Equus Ltd | Health & social care | 2014 |
| Somerset Estate Planning Limited | Professional & scientific | 2021 |
| Somerset Fire Protection Ltd | Construction | 2025 |
| Somerset Firedoors Ltd | Construction | 2026 |
| Somerset Firewood Ltd | Wholesale & retail | 2025 |
| Somerset GP Locums Limited | Administrative & support | 2005 |
| Somerset Gynaecology Service Limited | Health & social care | 2019 |
| Somerset Hale Limited | Real estate | 2017 |
| Somerset Healthcare Limited | Financial services | 2024 |
| Somerset House of Prayer CIC | Other services | 2025 |
| Somerset House Property Company Limited | Real estate | 2025 |
| Somerset Imaging Limited | Health & social care | 2020 |
| Somerset Industrial Doors Ltd | Construction | 2020 |
| Somerset Jobs Limited | Information & communication | 2020 |
| Somerset Joinery, Kitchens and Bedrooms Ltd | Manufacturing | 2013 |
| Somerset Land Limited | Real estate | 2015 |
| Somerset Lawn Care Ltd | Administrative & support | 2023 |