| SGP Consultancy Ltd | Professional & scientific | 2021 |
| Shadhin Ltd | Hospitality | 2018 |
| Shahbaz Said Limited | Transport & logistics | 2017 |
| Shahnaz Healthcare Limited | Health & social care | 2012 |
| Shalah Kruse Limited | Health & social care | 2026 |
| Shamrocked Ltd | Hospitality | 2013 |
| Shape Design Architectural Services Ltd | Professional & scientific | 2017 |
| Shape Technologies Limited | Information & communication | 2024 |
| Shapeskill Limited | Professional & scientific | 2006 |
| Sharky's Logistics Ltd | Transport & logistics | 2019 |
| Sharkyweb Limited | Information & communication | 2013 |
| Sharp Word Limited | Professional & scientific | 2025 |
| Sheehan Couriers Limited | Transport & logistics | 2021 |
| Sheepland Limited | Manufacturing | 2010 |
| Sheila Kirstein Limited | Extraterritorial | 2025 |
| Sheila Longman Limited | Extraterritorial | 2025 |
| Sherbrooke Medical Limited | Health & social care | 2023 |
| Sherford Court Taunton (Management) Limited | Households | 1986 |
| Sherford Limited | Manufacturing | 1999 |
| Sheridan Lodge RTM Company Limited | Households | 2006 |
| Sherlands Heights Residents Management Company Limited | Households | 2022 |
| Sherline Landscapes Ltd | Administrative & support | 2025 |
| Sherman Consultancy Ltd | Professional & scientific | 2010 |
| Sherman Property Limited | Real estate | 2022 |
| Sherrin Builders Limited | Construction | 2021 |
| Shfv Ltd | Financial services | 2021 |
| Shift Architecture Urbanism LLP | | 2017 |
| Shire Health Ltd | Health & social care | 2014 |
| Shire Surgical Limited | Health & social care | 2022 |
| Shirebury Ltd | Health & social care | 2026 |
| Shish and Chips Ltd | Hospitality | 2025 |
| Shisha Smoke Ltd | Wholesale & retail | 2023 |
| SHL 2025 Limited | Financial services | 2025 |
| Shortsmoor Limited | Extraterritorial | 2010 |
| Show Apparel Limited | Manufacturing | 2025 |
| Shustle Limited | Real estate | 2024 |
| Shuteleigh Finance Limited | Financial services | 2007 |
| Shyju Valamboor Photography Ltd | Professional & scientific | 2026 |
| SI Bradley Consulting Ltd | Professional & scientific | 2023 |
| Sian EYE Care Limited | Health & social care | 2019 |
| Sibs Trading Limited | Water & waste | 2013 |
| Sicurogroup UK Ltd | Information & communication | 2011 |
| Sidak Ltd | Transport & logistics | 2023 |
| Side Quest Games Ltd | Wholesale & retail | 2022 |
| Signature Coach Company Limited | Transport & logistics | 2017 |
| Signature Site & Property Services Ltd | Administrative & support | 2026 |
| Silex Consulting Limited | Information & communication | 2009 |
| Silex Resources Limited | Information & communication | 2008 |
| Silicon Konnect Ltd | Wholesale & retail | 2024 |
| Silver Scene Ltd | Wholesale & retail | 2004 |
| Silver Shield Security Ltd | Financial services | 2018 |
| Silver Street Motors (Holdings) Limited | Wholesale & retail | 2011 |
| Silver's Pantry Ltd | Hospitality | 2023 |
| Silvermeads Limited | Agriculture & fishing | 2021 |
| Silverton Agriculture Ltd | Agriculture & fishing | 2007 |
| Simantea Ltd | Professional & scientific | 2023 |
| Simon Dutton Associates Limited | Professional & scientific | 1999 |
| Simon Mccade Ltd | Professional & scientific | 2014 |
| Simon Pennels LLP | | 2007 |
| Simply Adhd Ltd | Health & social care | 2024 |
| Simply FOX Limited | Health & social care | 2017 |
| Simplypattesting Ltd | Manufacturing | 2025 |
| Simpson Wholesalers Limited | Wholesale & retail | 2023 |
| Sinapsy Ltd | Health & social care | 2023 |
| Sindri Brands Ltd | Wholesale & retail | 2026 |
| Singh and Sons Property Management Limited | Real estate | 2010 |
| Singh Imaging Enterprise Ltd | Health & social care | 2024 |
| SIRI1 Aesthetics Ltd | Professional & scientific | 2025 |
| Sisy Tech Solutions Ltd | Wholesale & retail | 2025 |
| Site Carpentry Limited | Construction | 2017 |
| Sitim Solutions Ltd | Water & waste | 2019 |
| Siwel Lewis & Co. Ltd | Construction | 2023 |
| SJ & Co Education Services Group Ltd | Education | 2025 |
| SJ Palmer Limited | Agriculture & fishing | 2014 |
| SJC Commercials Taunton Limited | Wholesale & retail | 2023 |
| SJC Consultants Ltd | Information & communication | 2013 |
| SJG Investments (South West) Ltd | Financial services | 2023 |
| SJG Motor Company Ltd | Wholesale & retail | 2026 |
| SJH Scientific Limited | Administrative & support | 2019 |
| SJK15 Limited | Professional & scientific | 2015 |
| SJM Properties South West Ltd | Real estate | 2020 |
| Sjml Holdings Ltd | Professional & scientific | 2015 |
| SJS Public Relations Ltd | Professional & scientific | 2015 |
| SJS South West Limited | Construction | 2008 |
| SK & Sons Barbers Ltd | Other services | 2013 |
| SK Aesthetics (SW) Ltd | Other services | 2023 |
| SK Parcels Ltd | Transport & logistics | 2015 |
| SK Supplies (Weymouth) Limited | Hospitality | 2019 |
| SKA Motors Ltd | Wholesale & retail | 2018 |
| Skalberg Ltd | Health & social care | 2011 |
| Skarnel Limited | Financial services | 2025 |
| Skewer House Limited | Hospitality | 2023 |
| Skewer House Taunton Limited | Hospitality | 2016 |
| SKL Electrical Ltd | Construction | 2017 |
| Skybound Services Limited | Transport & logistics | 1983 |
| Skye Business Services Limited | Administrative & support | 2017 |
| Skyone Limited | Information & communication | 2016 |
| SL Productions Ltd | Arts & recreation | 2019 |
| Slade Productions Ltd | Information & communication | 2026 |
| Slcc Enterprises Limited | Other services | 2006 |