| Elevator Technical Services Limited | Manufacturing | 2017 |
| Eleven 10 Architecture Limited | Professional & scientific | 2011 |
| Elex Electrical (South West) Ltd | Construction | 2023 |
| Elextec Limited | Construction | 2016 |
| Elianova Ltd | Wholesale & retail | 2022 |
| Elinet Enterprises Limited | Extraterritorial | 2002 |
| Elite Care Anaesthesia Services Ltd | Health & social care | 2024 |
| Elite Composite Technologies Ltd | Manufacturing | 2025 |
| Elite Construction (Cambs) Limited | Construction | 2018 |
| Elite Decorators SW Ltd | Construction | 2023 |
| Elite Facades (South West) Ltd | Construction | 2026 |
| Elite Financial Associates Ltd | Financial services | 2016 |
| Elite Hair Design Limited | Other services | 2002 |
| Elite Landscaping & Gardening Ltd | Administrative & support | 2016 |
| Elite Outdoor Media Services Ltd | Administrative & support | 2018 |
| Elite Properties South West Ltd | Real estate | 2025 |
| Elite Staffing Solutions (South West) Ltd | Administrative & support | 2015 |
| Elite Stone Installation Ltd | Construction | 2025 |
| Elite TEK Limited | Information & communication | 2025 |
| Elitefts UK Ltd | Wholesale & retail | 2018 |
| Elizabeth Allinson Art Limited | Wholesale & retail | 2025 |
| Elizabeth Ambrose Property Ltd | Financial services | 2025 |
| Elkhound Holdings Limited | Financial services | 2022 |
| Ellan Developments Limited | Financial services | 2021 |
| Ellard Security Systems (Residential Installations) Limited | Administrative & support | 2017 |
| Ellard Security Systems Limited | Administrative & support | 2005 |
| Ellen & MAY Ltd | Financial services | 2023 |
| Ellendale Engineering Limited | Manufacturing | 1984 |
| Ellicombe Gardens (Minehead) Management Company Limited | Real estate | 2014 |
| Ellis Services Limited | Real estate | 2018 |
| ELM Park Management (Taunton) Limited | Real estate | 1982 |
| Elninio Ltd | Professional & scientific | 2020 |
| ELS Property Partners Limited | Construction | 2026 |
| Elsav Holdings Limited | Financial services | 2025 |
| Elsav Media Limited | Information & communication | 2026 |
| Elsav Renewables Limited | Other services | 2025 |
| Elsewhere Communications and Management Limited | Administrative & support | 2025 |
| Elvet Bridge Limited | Professional & scientific | 2024 |
| Elwee Limited | Professional & scientific | 2009 |
| Elzinga & Oterdoom Procesmanagement LLP | | 2016 |
| EM Lift Services Ltd | Construction | 2026 |
| Emare Ltd | Wholesale & retail | 2024 |
| Ember Sky Therapy Ltd | Health & social care | 2025 |
| EMC GMC Property Ltd | Real estate | 2025 |
| EME Homes Ltd | Construction | 2024 |
| EMF Shielding Limited | Extraterritorial | 2016 |
| Emfix Limited | Health & social care | 2025 |
| Emily Elgar Limited | Arts & recreation | 2016 |
| Emily's Canine Country Limited | Other services | 2019 |
| Emmanails Ltd | Other services | 2014 |
| Emmett Farming Limited | Agriculture & fishing | 2012 |
| Emojen Limited | Health & social care | 2025 |
| Emperor Penguin Group Limited | Information & communication | 2016 |
| Empower Family Group Limited | Financial services | 2020 |
| Empower Fostering Limited | Health & social care | 2020 |
| Empower Outreach Limited | Health & social care | 2020 |
| Empower Residentials Limited | Health & social care | 2018 |
| Empower Supported Living Limited | Health & social care | 2023 |
| Empowered Achiever Limited | Information & communication | 2007 |
| Empyrean Fire Consultancy Ltd | Public administration | 2026 |
| Emraf Consulting Limited | Professional & scientific | 2025 |
| Emrils Limited | Other services | 2016 |
| Emro Property Ltd | Real estate | 2026 |
| Emtech Global Ltd | Wholesale & retail | 2025 |
| Enable Futures Group Ltd | Administrative & support | 2019 |
| Encanto Aesthetics Ltd | Health & social care | 2022 |
| Enceladus Engineering Ltd | Administrative & support | 2017 |
| Endriu Construction Ltd | Construction | 2023 |
| Enefar Limited | Professional & scientific | 2011 |
| Energise Group Ltd | Construction | 2025 |
| Energy Market Holdings Ltd | Real estate | 2017 |
| Energy Wallet Limited | Financial services | 2022 |
| Energykey Ltd | Manufacturing | 2024 |
| Engage Solutions Ltd | Professional & scientific | 2003 |
| Engine Room Properties Commercial Limited | Real estate | 2022 |
| Engine Room Properties Limited | Real estate | 2021 |
| Engine Room Properties Services LLP | | 2021 |
| Engineering Evolution Limited | Professional & scientific | 2019 |
| Enhance Taunton Ltd | Other services | 2024 |
| Entangled Earth Ltd | Agriculture & fishing | 2021 |
| Entertainment for Life Limited | Arts & recreation | 2021 |
| Entertainment Unlimited Limited | Arts & recreation | 2018 |
| Enticknap Enterprises Ltd | Hospitality | 2024 |
| Envision Enterprises Limited | Information & communication | 2013 |
| Enys Estate Company Limited | Real estate | 2016 |
| Enys Farms Partnership LLP | | 2020 |
| Eohippus Limited | Real estate | 2023 |
| EP Investing Limited | Financial services | 2023 |
| EP Law (SW) Ltd | Professional & scientific | 2025 |
| EP Mortgages Ltd | Financial services | 2025 |
| Epaywise Limited | Information & communication | 2009 |
| EPC Somerset Ltd | Professional & scientific | 2025 |
| Epoch Properties 1 Limited | Real estate | 2014 |
| Epoch Properties 2 Limited | Real estate | 2018 |
| EPS Services & Tooling Limited | Manufacturing | 2010 |
| Equilateral Distributions Ltd | Wholesale & retail | 2026 |
| Equinox Civil Engineering Limited | Administrative & support | 2013 |
| Equityclimate Ltd | Professional & scientific | 2022 |
| Ergyun Ltd | Health & social care | 2023 |
| Eric Marlborough Services Limited | Professional & scientific | 2024 |