| Eris Engineers Limited | Professional & scientific | 2018 |
| Ernest Home Improvements Ltd | Construction | 2022 |
| ERW Mechanics Ltd | Wholesale & retail | 2024 |
| Escalla TS Ltd | Information & communication | 2005 |
| Escape Tours Limited | Transport & logistics | 2025 |
| Escape West Limited | Real estate | 2020 |
| Escot Estate Partnership Limited | Extraterritorial | 2022 |
| Eset Research UK Limited | Information & communication | 2011 |
| ESG Natural Capital (Management) Ltd | Professional & scientific | 2020 |
| ESG Natural Capital Ltd | Professional & scientific | 2021 |
| ESH Commercial Ltd | Water & waste | 2020 |
| Esher Holdings Limited | Extraterritorial | 2022 |
| Eskeez Ltd | Wholesale & retail | 2009 |
| Esmonde Drive (Ilchester) Residents Company Limited | Households | 2002 |
| Esox Cottage Lettings Limited | Real estate | 2024 |
| Essence Private Limited | Real estate | 2019 |
| Essex and Suffolk Equine Vets Ltd | Professional & scientific | 2022 |
| Essex Court Management(Taunton)Limited | Households | 1966 |
| Esstar Limited | Real estate | 2024 |
| Estates Mitchell Portfolios Limited | Real estate | 2021 |
| Estuary Clinic Ltd | Health & social care | 2014 |
| ESU Medical Solutions Limited | Manufacturing | 2022 |
| Esubs Consulting and Services Limited | Information & communication | 2023 |
| Esvic Medical Services Limited | Health & social care | 2022 |
| Esworthy Properties Limited | Real estate | 2014 |
| Etech Electrical Contractors & Engineers Limited | Construction | 2011 |
| Etty Ltd | Information & communication | 2023 |
| Eugento Limited | Manufacturing | 2021 |
| Euro Eastgate Ltd | Wholesale & retail | 2022 |
| Euroduty Limited | Arts & recreation | 1997 |
| European Administration Limited | Administrative & support | 2001 |
| European Superstore Taunton Ltd | Wholesale & retail | 2023 |
| Europonics PTY Ltd | | 1992 |
| Eurostove Holdings Limited | Financial services | 2017 |
| Eurostove Limited | Wholesale & retail | 2004 |
| Eurowa Limited | Transport & logistics | 2013 |
| EV L&M Hair Ltd | Other services | 2024 |
| EV NRG Ltd | Energy | 2019 |
| Evans Motorcraft Limited | Wholesale & retail | 2020 |
| Evans Motorcycles Ltd | Wholesale & retail | 2025 |
| EVE Beauty Studio Limited | Other services | 2022 |
| Eve'Ll Industries Limited | Information & communication | 2012 |
| Evenari Veterinary Services Limited | Financial services | 2021 |
| Event Medical & Training Ltd | Education | 2024 |
| Event Security Staffing Solutions Ltd | Administrative & support | 2025 |
| Everest Natural Pet Company Ltd | Wholesale & retail | 2023 |
| Everett Fine Art Limited | Other services | 2001 |
| Everett Holdings Ltd | Financial services | 2025 |
| Every Level Fitness Ltd | Arts & recreation | 2022 |
| Everything Outside Limited | Administrative & support | 2024 |
| EVO Academy Group Limited | Education | 2024 |
| EVO Agency Ltd | Information & communication | 2005 |
| EVO Innovation Group Ltd | Information & communication | 2026 |
| EVO Talent Group Ltd | Administrative & support | 2023 |
| Evohome Limited | Wholesale & retail | 2021 |
| Evolution Construction (Southwest) Ltd. | Construction | 2021 |
| Evolution Haus (GB) Limited | Professional & scientific | 2025 |
| Evolution Kickboxing Academy Limited | Health & social care | 2018 |
| Evolve Child Care Limited | Health & social care | 2020 |
| Evolving Energy Limited | Construction | 2021 |
| Evry Chance Ltd | Wholesale & retail | 2021 |
| Ewens & Johnson (2020) Limited | Real estate | 2003 |
| Exam Experts Ltd | Education | 2025 |
| Excalibur Gaming Limited | Wholesale & retail | 2019 |
| Excelsia Services Ltd | Administrative & support | 2025 |
| Exchange House (Taunton) Limited | Hospitality | 2008 |
| Exclusive Taxis Ltd | Transport & logistics | 2026 |
| Exelin Limited | Professional & scientific | 2013 |
| Exeter Accounting Services Limited | Professional & scientific | 2023 |
| Exeter Cookery School Ltd | Education | 2015 |
| Exeter Dermatology Limited | Health & social care | 2010 |
| Exeter Property Group Ltd | Real estate | 2023 |
| Exley Watts Limited | Professional & scientific | 2018 |
| Exmoor Aerials Ltd | Other services | 2015 |
| Exmoor Carpentry Ltd | Construction | 2025 |
| Exmoor Commercial Property Limited | Real estate | 2015 |
| Exmoor Drinks Ltd | Wholesale & retail | 2025 |
| Exmoor Flagstones Ltd | Construction | 2026 |
| Exmoor Garage Ltd | Wholesale & retail | 2019 |
| Exmoor HAY & Straw Ltd | Transport & logistics | 2007 |
| Exmoor Laundry Ltd | Other services | 2025 |
| Exmoor Property Holdings Limited | Real estate | 2019 |
| Exmoor Trim Holdings Ltd | Financial services | 2021 |
| Exmoor Trim Limited | Manufacturing | 2002 |
| Exmoor Trim Trustees Limited | Financial services | 2022 |
| Exmoor Venison Limited | Manufacturing | 2025 |
| Exmouth Leisure Limited | Arts & recreation | 2003 |
| Experience Wine Limited | Wholesale & retail | 2007 |
| Exploit the Web Limited | Information & communication | 2009 |
| Expression (Pinhoe 2) Management Company Limited | Real estate | 2018 |
| Expression (Pinhoe) Management Company Limited | Households | 2017 |
| Exquisite Dermatology Ltd | Health & social care | 2025 |
| Extoursuk Ltd | Administrative & support | 2024 |
| Extra Mile Automotive Limited | Wholesale & retail | 2022 |
| Extra Mile Printing Ltd | Manufacturing | 2016 |
| Extremely Good Limited | Information & communication | 2014 |
| Eyre Holdings Limited | Professional & scientific | 1981 |
| EZD Properties Ltd | Real estate | 2026 |
| F G Pryor and SON Limited | Agriculture & fishing | 2009 |
| F&J Mcgowan Ltd | Professional & scientific | 2016 |