| DPS Holdings Limited | Financial services | 2018 |
| DR CEI Aesthetics Limited | Other services | 2025 |
| DR D W Pryce Ltd | Health & social care | 2011 |
| DR Dotittle Veterinary Services Limited | Professional & scientific | 2021 |
| DR JD Budd Medicolegal Ltd | Professional & scientific | 2012 |
| DR Kirk Limited | Health & social care | 2022 |
| DR Luke Gompels Ltd | Health & social care | 2011 |
| DR Samuel Lawton Ltd | Health & social care | 2025 |
| Dragans Auto Repair Limited | Wholesale & retail | 2025 |
| Dragon Family Learning CIC | Education | 2023 |
| Dragon Kiss Limited | Hospitality | 2019 |
| Drainfix Southwest Ltd | Construction | 2012 |
| Drake Vets Holdings Limited | Professional & scientific | 2021 |
| Drake Vets Limited | Professional & scientific | 2009 |
| Drasan Limited | Households | 2023 |
| DRB Scaffolding Ltd | Construction | 2010 |
| Drbaines.Com Ltd | Health & social care | 2015 |
| DRC 1 Limited | Professional & scientific | 2020 |
| Dream Machine Media Limited | Administrative & support | 2009 |
| Dream Space Renovations Ltd | Construction | 2026 |
| Dreambound Properties Ltd | Extraterritorial | 2021 |
| Dreamcraft (South West) Limited | Real estate | 2002 |
| Dreams Valley Creations Limited | Wholesale & retail | 2022 |
| Dreamtime Productions (UK) Ltd | Arts & recreation | 2014 |
| Drew Hardy Ltd | Arts & recreation | 2021 |
| Drewstridecoaching Ltd | Education | 2025 |
| DRH Haulage Limited | Transport & logistics | 2022 |
| Drhm Consulting Ltd | Education | 2018 |
| Drippy Bear Tattoo Studio Ltd | Other services | 2024 |
| Driss Properties Limited | Construction | 2005 |
| Drive Force Recruitment Limited | Administrative & support | 2008 |
| Drive IT School of Motoring Limited | Education | 2020 |
| Drive Technology Holland Limited | Construction | 2006 |
| Drsgunawardenaterlevich Ltd | Health & social care | 2019 |
| Drummers Farming Limited | Agriculture & fishing | 2018 |
| Drummond Trade Limited | Wholesale & retail | 2010 |
| Drysdale Medical Ltd | Health & social care | 2013 |
| DS Developments (Wiltshire) Limited | Construction | 2017 |
| DS Property Partners Ltd | Real estate | 2025 |
| DS Tiling Ltd | Construction | 2020 |
| DSC (Nederland) Limited | Manufacturing | 2008 |
| DSC Tennis Coaching Limited | Arts & recreation | 2014 |
| DSL Holdings Ltd | Financial services | 2026 |
| Dsr.Welders&Burners Limited | Manufacturing | 2021 |
| DTN Family Investments Limited | Professional & scientific | 2021 |
| DTN Holdings SW Limited | Professional & scientific | 2021 |
| Dub'L LIF (Taunton) Limited | Manufacturing | 1977 |
| Duck Plumbing & Heating Limited | Construction | 2006 |
| Duende Travel Limited | Administrative & support | 1995 |
| Duffy-Allen Ltd | Financial services | 2025 |
| Dulverton Transport Ltd | Transport & logistics | 2020 |
| Dulverton Veterinary Practice Limited | Professional & scientific | 2010 |
| Dumbledore Vets Limited | Professional & scientific | 2022 |
| Dump Truck Holdings Ltd | Information & communication | 2021 |
| Dunball Construction Ltd | Construction | 2015 |
| Duncan & Daughters Limited | Financial services | 2022 |
| Duncan Westcott Ltd | Manufacturing | 2018 |
| Duncliffe Homes Limited | Construction | 2016 |
| Dunheved Gardens Management Company Limited | Households | 2025 |
| Dunkley Property Ltd | Real estate | 2015 |
| Dunkley Shoulders Ltd | Health & social care | 2019 |
| Dunns (Exeter) Limited | Extraterritorial | 1959 |
| Dunns Estates (Exeter) Limited | Real estate | 2017 |
| Dunns Motors (Exeter) Limited | Real estate | 1969 |
| Dunns Motors (Holdings) Limited | Real estate | 2015 |
| Dunstan House Electrical Limited | Construction | 2003 |
| Dunstan House Properties Limited | Real estate | 2009 |
| Durell Investments Limited | Financial services | 2022 |
| Durell Software Limited | Information & communication | 1983 |
| Dustquip Limited | Extraterritorial | 2024 |
| Dutch Beauty Limited | Hospitality | 2008 |
| Duxback Limited | Wholesale & retail | 2007 |
| DVP Properties Limited | Real estate | 2017 |
| DW & JM Owen Limited | Professional & scientific | 2018 |
| DW Building Contractors Ltd | Construction | 2015 |
| Dynamic Perceptions Ltd. | Administrative & support | 2000 |
| Dyte Property Solutions Limited | Real estate | 2024 |
| E & J Cleaning Services Ltd | Administrative & support | 2024 |
| E & P Bloodstock Limited | Arts & recreation | 2026 |
| E Leung Finance Limited | Professional & scientific | 2019 |
| E O E Limited | Professional & scientific | 2019 |
| E&A Trade Ltd | Real estate | 2022 |
| E&Js Management Ltd | Real estate | 2023 |
| E-Motive Holdings Ltd | Manufacturing | 2016 |
| E.S.Triggol Limited | Agriculture & fishing | 1959 |
| E.W. Quick & A.E. Quick Ltd | Agriculture & fishing | 2003 |
| E5 Design and Illustration Limited | Arts & recreation | 2022 |
| EA Medical Southwest Limited | Health & social care | 2019 |
| EAD1 Limited | Real estate | 2026 |
| Eagle Close (Ilchester) Residents Company Limited | Households | 2001 |
| EAO Veterinary Services Limited | Professional & scientific | 2023 |
| Eardley Consulting Ltd | Wholesale & retail | 2025 |
| Eardley Retail Ltd | Wholesale & retail | 2021 |
| Eardleys Retail Ltd | Wholesale & retail | 2023 |
| Earlam & Christopher Limited | Wholesale & retail | 2014 |
| Earland Rise Management Company Limited | Households | 2020 |
| Early Day Films Limited | Information & communication | 2004 |
| Earthworks & Aggregates Ltd | Water & waste | 2024 |
| East Culme Farm Limited | Agriculture & fishing | 1928 |
| East Devon Water Softeners Limited | Construction | 2011 |