| Devon School of Yoga Ltd | Public administration | 2012 |
| Dewland & SON Contractors Ltd | Professional & scientific | 2020 |
| Dewsbury Railway Cafe Ltd | Hospitality | 2019 |
| Dezzey Ltd | Professional & scientific | 2009 |
| DG 2021 Limited | Professional & scientific | 2022 |
| DG Build ME Ltd | Construction | 2015 |
| DG Finco Limited | Professional & scientific | 2022 |
| DG Plumbing & Heating (Somerset) Limited | Construction | 2016 |
| DG Risk Consultants Limited | Administrative & support | 2014 |
| Dgea Ltd | Administrative & support | 2018 |
| DHG Properties Ltd | Real estate | 2021 |
| DHS Realisations Limited | Wholesale & retail | 2016 |
| Diamedica (UK) Limited | Manufacturing | 2008 |
| Diamedica Developments Ltd | Financial services | 2020 |
| Diamedica Holdings Limited | Financial services | 2019 |
| Diamedica Limited | Extraterritorial | 2004 |
| Diamond Grass Ltd | Administrative & support | 2024 |
| Diamond Lane Holdings Ltd | Financial services | 2025 |
| Dick & Willie’S Ltd | Manufacturing | 2023 |
| Dicla Invest Ltd | Real estate | 2024 |
| Didi Rugby Raffey Ltd | Other services | 2024 |
| Didy Property Maintenance Ltd | Construction | 2022 |
| Diepenbroek Farms Ltd | Agriculture & fishing | 2014 |
| Dietcolvin Limited | Health & social care | 2016 |
| Digby & Litten Ltd | Wholesale & retail | 2020 |
| Digital Claims Services Limited | Information & communication | 2014 |
| Digital Consultation Ltd | Information & communication | 2019 |
| Digital Delivery Group Limited | Extraterritorial | 2018 |
| Digital HR Ltd | Hospitality | 2015 |
| Digital Neuro Innovations CIC | Professional & scientific | 2019 |
| Digitization Ltd | Information & communication | 2014 |
| Dignitycare Hub Ltd | Wholesale & retail | 2025 |
| Diligent Imaging & Intervention Limited | Health & social care | 2014 |
| Diligent Property Services Limited | Real estate | 2016 |
| DIM Groep Limited | Professional & scientific | 2010 |
| Dingbatt Dog Training Limited | Education | 2023 |
| Dinky Meals Limited | Hospitality | 2019 |
| Dionysus Consulting Services Limited | Professional & scientific | 2024 |
| DIP Tanks (Southwest) Limited | Wholesale & retail | 2020 |
| Direct Access Barristers Limited | Professional & scientific | 2026 |
| Direct Education Services Ltd | Education | 2023 |
| Direct Utility Solutions Ltd | Construction | 2015 |
| Dirt Monkey Products Ltd | Wholesale & retail | 2023 |
| Disabled Workers Co-Operative Limited | Other services | 2002 |
| Discover Properties Ltd | Real estate | 2024 |
| Discover Upholstery Ltd | Extraterritorial | 2016 |
| Distinctive Creative Ltd | Information & communication | 2022 |
| Distributor Doctor Limited | Wholesale & retail | 2012 |
| Diya Technologies Ltd | Information & communication | 2019 |
| DJ Mugz & Printz Ltd | Wholesale & retail | 2018 |
| DJ Wilde Consulting Limited | Professional & scientific | 2023 |
| DJD Genuine Cars Ltd | Wholesale & retail | 2014 |
| DJS Medical Services Limited | Health & social care | 2019 |
| DK Food Safety Ltd | Professional & scientific | 2024 |
| DL4C Ltd | Manufacturing | 2012 |
| DM Property SW Limited | Real estate | 2022 |
| DM South West Solutions Ltd | Wholesale & retail | 2023 |
| DMC3 Ltd | Construction | 2025 |
| DMD Global Truck Ltd | Construction | 2015 |
| DMJ Global Group Ltd | Financial services | 2024 |
| DMJ SUB Limited | Hospitality | 2019 |
| DMO Electrical Services (SW) Ltd | Construction | 2023 |
| DMS (SW) Ltd | Professional & scientific | 2023 |
| DMS Drywall Systems Limited | Construction | 2019 |
| Dnys Properties Ltd | Real estate | 2019 |
| Doble Close Residents Association Limited | Households | 2012 |
| Doble Properties Ltd | Professional & scientific | 2007 |
| Dodgy Garage Limited | Wholesale & retail | 2024 |
| Dog Daze Studio Limited | Information & communication | 2026 |
| Doggy Doctor Ltd | Professional & scientific | 2004 |
| Dogs & Duvets Ltd | Wholesale & retail | 2024 |
| Dolton Homes Limited | Construction | 2009 |
| Dominic Chapman Consulting Services Ltd | Hospitality | 2024 |
| Domira Limited | Information & communication | 2004 |
| DON Druitt (Sales) Limited | Wholesale & retail | 1977 |
| Donal Bingham T/A Active Tree Care Limited | Agriculture & fishing | 2017 |
| Donfabs & Consillia Limited | Manufacturing | 2009 |
| Doom Tattoo Ltd | Other services | 2015 |
| Doonhamer Media Ltd | Arts & recreation | 2018 |
| DOR Telerad Ltd | Information & communication | 2024 |
| Dorchester Court (Yeovil) Management Company Limited | Households | 2009 |
| Dordan Limited | Extraterritorial | 2015 |
| Doridel Management Limited | Real estate | 2021 |
| Dorset and Somerset Training Provider Network Ltd | Education | 2009 |
| Dorset Ophthalmology Ltd | Health & social care | 2014 |
| Dosac Limited | Professional & scientific | 2018 |
| Dosinia Ltd | Professional & scientific | 2024 |
| Double L Electrical Company Ltd | Construction | 2025 |
| Dough & Digital Ltd | Wholesale & retail | 2025 |
| Dough Bros Bakery Limited | Wholesale & retail | 2025 |
| Dough South West Ltd | Wholesale & retail | 2020 |
| Dovetail Court Management Limited | Households | 1988 |
| Downing & Sons Limited | Extraterritorial | 2019 |
| Downland Health and Wellbeing Ltd | Health & social care | 2026 |
| Downs Veterinary Referrals Limited | Professional & scientific | 2007 |
| Dowrich Farms Limited | Agriculture & fishing | 1955 |
| Doxa Consulting Ltd | Wholesale & retail | 2014 |
| DPC Partnership Limited | Professional & scientific | 2008 |
| DPJ Hospitality Limited | Hospitality | 2021 |
| Dpmit Ltd | Information & communication | 2019 |