| Space Found Ltd | Professional & scientific | 2022 |
| Spark Speech Limited | Administrative & support | 2025 |
| Sparkle Hygiene Limited | Wholesale & retail | 2006 |
| Sparkle Laundry Ltd | Administrative & support | 2025 |
| SPARKLE18 Ltd | Administrative & support | 2016 |
| Sparsh Azil Ltd | Hospitality | 2023 |
| Spartan Bricklaying Ltd | Construction | 2021 |
| Specialist Global Windscreens Limited | Wholesale & retail | 2026 |
| Spectrum Services (Tamworth) Ltd | Manufacturing | 1997 |
| Speed Wheels Limited | Transport & logistics | 2016 |
| SPG Transportation and Logistics Ltd | Transport & logistics | 2024 |
| SPH Quality Limited | Professional & scientific | 2024 |
| Spice Birmingham Limited | Other services | 2003 |
| Spice Street Tamworth Ltd | Hospitality | 2025 |
| Spiers Associates Ltd | Professional & scientific | 2011 |
| Spiers Group Ltd | Professional & scientific | 2017 |
| Spiers Ltd | Professional & scientific | 2011 |
| Spierstrong Property Management Ltd | Real estate | 2019 |
| Spin-It Limited | Manufacturing | 2008 |
| Spinningfields Media Group Limited | Professional & scientific | 2015 |
| Spline Gauges Limited | Manufacturing | 1994 |
| SPO Services Ltd | Manufacturing | 2019 |
| Spotted Dog Taverns Ltd | Hospitality | 2025 |
| Spotted Midlands Limited | Professional & scientific | 2018 |
| Spray Booth Wizards Ltd | Manufacturing | 2024 |
| Spring Garden and Home Holdings Limited | Wholesale & retail | 2020 |
| Springfield Windows and Doors Ltd | Construction | 2014 |
| Sprinkles Cupcakes and Bakes Limited | Hospitality | 2020 |
| Sprint Education Recruitment Ltd | Administrative & support | 2024 |
| SPS Bathrooms & Plumbing Ltd | Construction | 2011 |
| Spure Limited | Administrative & support | 2018 |
| Square Solutions (Consulting) Ltd | Professional & scientific | 2013 |
| SR & AB Property Holdings Limited | Households | 2025 |
| SRH Accounts Limited | Professional & scientific | 2016 |
| SRI Plumbing and Heating Ltd | Construction | 2025 |
| SRI Valli Retail Ltd | Wholesale & retail | 2020 |
| SRL Contracts Ltd | Construction | 2025 |
| SRM Distribution Ltd | Transport & logistics | 2020 |
| SRP Building Ltd | Real estate | 2019 |
| SRS GAS & Water Utilities Limited | Construction | 2009 |
| SRT Accommodation Ltd | Hospitality | 2024 |
| SS Embroidery Ltd | Manufacturing | 2024 |
| SSB Cars Ltd | Wholesale & retail | 2023 |
| SSC Audits Ltd | Professional & scientific | 2024 |
| Sstonehouse Ltd | Arts & recreation | 2021 |
| ST Andrews Property Company. Ltd | Real estate | 2015 |
| ST Anns Old Mine Lane Limited | Construction | 2026 |
| ST Telbin Ltd | Professional & scientific | 2022 |
| Stable Express Limited | Other services | 2009 |
| Staffordshire Advanced Practice Solutions Ltd | Health & social care | 2024 |
| Staffordshire Blinds Limited | Manufacturing | 2025 |
| Staffpacks Limited | Information & communication | 2017 |
| Staffspower Electrical Contractors Limited | Construction | 2025 |
| Stage 4 Design Limited | Professional & scientific | 2026 |
| Stage and Shine Ltd | Administrative & support | 2020 |
| Stagefight Limited | Education | 2009 |
| Stainless Tube & Needle Company Limited | Manufacturing | 1989 |
| Standon Gardens Limited | Health & social care | 2013 |
| Standon House and Gardens Holdings Limited | Financial services | 2018 |
| Star Talkers Limited | Health & social care | 2014 |
| Starliner Ltd | Transport & logistics | 2024 |
| Starttray Ltd | Administrative & support | 2024 |
| Statfold Engineering Ltd | Professional & scientific | 2017 |
| Statfold Narrow Gauge Museum (Trading) Limited | Arts & recreation | 2018 |
| Statfold Narrow Gauge Museum Trust Ltd | Arts & recreation | 2017 |
| Statfold Seed OIL Developments Limited | Manufacturing | 1998 |
| Statutory Inspections Ltd | Professional & scientific | 2006 |
| Stealth Tech Ltd | Wholesale & retail | 2015 |
| Stedek Holdings Limited | Financial services | 2025 |
| Stedek Windows & Doors Limited | Construction | 2005 |
| Steele and INK Tattoos Limited | Arts & recreation | 2018 |
| Step in Stone Limited | Professional & scientific | 2005 |
| Stephanie's Studio One Hair of the Dog Ltd | Other services | 2024 |
| Stephen J Weaver (Woofferton) Limited | Transport & logistics | 2003 |
| Steps for Success A&O Limited | Administrative & support | 2019 |
| Sterling Security Systems Limited | Other services | 1990 |
| Stevenson Auto Services Ltd | Wholesale & retail | 2025 |
| Stevensons of Uttoxeter Limited | Transport & logistics | 2025 |
| Steves Cars 247 247 Ltd | Transport & logistics | 2021 |
| Steves Fish Bar LLP | | 2022 |
| STH Trading Limited | Professional & scientific | 2010 |
| Still Game Party Limited | Information & communication | 2022 |
| Stockley Electrics Limited | Construction | 1999 |
| Stockley Studios Ltd | Other services | 2025 |
| Stoneacre Advisors Limited | Professional & scientific | 2024 |
| Stonic Ltd | Transport & logistics | 2025 |
| Stonydelph Limited | Agriculture & fishing | 1983 |
| Storks Logistics Ltd | Transport & logistics | 2024 |
| Stradvert Ltd | Professional & scientific | 2024 |
| Straight Banana Limited | Professional & scientific | 2019 |
| Straight LAY Flooring Ltd | Construction | 2015 |
| Straight White Teeth Birmingham Ltd | Health & social care | 2021 |
| Strata Talent Group Limited | Administrative & support | 2026 |
| Stratique Limited | Professional & scientific | 2003 |
| Strawberries Childcare Ltd | Health & social care | 2026 |
| Strawberry Leisure Limited | Professional & scientific | 1976 |
| Streathers Limited | Extraterritorial | 2003 |
| Street Eats Catering Co. Limited | Hospitality | 2022 |
| Streetly Technical Services Limited | Financial services | 2019 |
| Strexa Limited | Information & communication | 2025 |