| Strong Build Developments Limited | Construction | 2020 |
| Strong's Plastic Products Limited | Manufacturing | 1985 |
| Strongarm Security Ltd | Administrative & support | 2002 |
| Stronghold Contractors Ltd | Construction | 2016 |
| Stronghold Group Limited | Financial services | 2023 |
| Stronghold Homes (ES) Limited | Construction | 2022 |
| Stronghold Homes (SG) Limited | Construction | 2024 |
| Stronghold Homes Limited | Construction | 2015 |
| Stronghold Property (Midlands) Ltd | Construction | 2024 |
| Sttc Property Ltd | Real estate | 2020 |
| Stuart Brown Plumbing and Heating Limited | Construction | 2002 |
| Stuart Patrick Ltd | Energy | 2010 |
| Stuarts Properties Limited | Real estate | 1996 |
| Studio One Hair & Beauty Limited | Other services | 1980 |
| Style Club Limited | Wholesale & retail | 1992 |
| Style Junkies Limited | Wholesale & retail | 2024 |
| Styled Educational Enterprises Ltd | Education | 2024 |
| Subsafe Solutions Ltd | Manufacturing | 2025 |
| Sudanese Primary Care Ltd | Health & social care | 2024 |
| Suki Search & Rescue Ltd | Information & communication | 2025 |
| Summit Chilled Limited | Extraterritorial | 2017 |
| Summit Enrolment Solutions Ltd | Construction | 2023 |
| Summit Explorers Ltd | Administrative & support | 2024 |
| Summit Protech Ltd | Manufacturing | 2021 |
| Summit Recycling Systems Limited | Water & waste | 2010 |
| Summit Systems Fabrication Limited | Manufacturing | 2010 |
| Summit Systems Limited | Manufacturing | 1990 |
| Suncream Dairies Limited | Manufacturing | 1984 |
| Suncream Holdings Limited | Professional & scientific | 1975 |
| Super Marine Investment (Rentals) Ltd | Administrative & support | 2018 |
| Superclass Clean Ltd | Administrative & support | 2026 |
| Supply Staffing Limited | Education | 2018 |
| Suprajit Europe Limited | Transport & logistics | 2006 |
| Supreme Blinds and Interiors Ltd | Wholesale & retail | 2013 |
| Supreme Clientele Ltd | Information & communication | 2023 |
| Supreme Kitchens Limited | Professional & scientific | 2012 |
| Sure Way Lifting Limited | Professional & scientific | 2008 |
| Sure Way Lifting Services Limited | Administrative & support | 2015 |
| Sure Way Plant Hire Limited | Administrative & support | 2015 |
| Sureserv Limited | Manufacturing | 2006 |
| Suretec Products Ltd | Manufacturing | 2020 |
| Surface Repair Network Ltd | Manufacturing | 2016 |
| Surface Technik (Dudley) Limited | Manufacturing | 2020 |
| Surface Technik (Holdings) Limited | Manufacturing | 1991 |
| Surface Technik (Tamworth) Limited | Manufacturing | 1991 |
| Surface Technik Services Ltd | Manufacturing | 2006 |
| Surveyseller Ltd | Wholesale & retail | 2017 |
| Sushi BAO House Ltd | Hospitality | 2025 |
| Sustavian Limited | Professional & scientific | 2020 |
| Sutton & Hempstead Limited | Real estate | 2023 |
| Sutton Coldfield Electrical Ltd. | Construction | 2012 |
| Sutton Coldfield Glass & Glazing Limited | Wholesale & retail | 2013 |
| Sutton Mortgage Centre UK Ltd | Financial services | 2020 |
| Sutton Motorcycles Tamworth Limited | Wholesale & retail | 2003 |
| Suttons Agricultural and Transport Ltd | Transport & logistics | 2024 |
| SVH Consultancy Services Ltd | Professional & scientific | 2024 |
| SW Building & Construction Ltd | Construction | 2022 |
| SW Interior Linings Ltd | Construction | 2014 |
| SW Property Ltd | Real estate | 2020 |
| SW Social Ltd | Professional & scientific | 2020 |
| Swags and Tags Dog Grooming Ltd | Other services | 2020 |
| Swan Holdings Group Ltd | Financial services | 2024 |
| Swan Park Estates Ltd | Real estate | 2017 |
| SWD Precision Limited | Manufacturing | 2002 |
| Sweet Care 4 U Limited | Health & social care | 2025 |
| Sweet Dreams Retreats Limited | Hospitality | 2026 |
| Sweet Oyster Catering Ltd | Hospitality | 2022 |
| Swift Commercial Furniture Ltd | Wholesale & retail | 2025 |
| Swift Van Hire Ltd | Administrative & support | 2015 |
| Swim Skills Academy Limited | Education | 2015 |
| Swing and Slide Ltd | Manufacturing | 2025 |
| Switching Group Limited | Energy | 2004 |
| Swysh Concierge Ltd | Hospitality | 2021 |
| Swysh Holidays Ltd | Hospitality | 2020 |
| Sycamore Properties Limited | Real estate | 1998 |
| Sycamore Skin Ltd | Other services | 2025 |
| Sylheti Curry Ltd | Hospitality | 2025 |
| Symbiox Limited | Health & social care | 2023 |
| Symply Ltd | Information & communication | 2018 |
| Synaptx Ltd | Administrative & support | 2026 |
| Syndora Alto Technology Limited | Information & communication | 2025 |
| Synergy Building Design Limited | Professional & scientific | 2013 |
| Synergy Group Services Ltd | Construction | 2015 |
| Synergy Property Maintenance Ltd | Construction | 2025 |
| Synovio Life Sciences Limited | Administrative & support | 2024 |
| Systems and Software Limited | Information & communication | 1997 |
| Szostak Limited | Transport & logistics | 2012 |
| T & D Electrical Services Limited | Construction | 2005 |
| T F D Europe Limited | Information & communication | 1995 |
| T G Design Solutions Limited | Professional & scientific | 2003 |
| T H S Plastics Limited | Manufacturing | 2006 |
| T in Techno Ltd | Arts & recreation | 2018 |
| T J Cunningham Construction Limited | Construction | 2016 |
| T J Travel Limited | Transport & logistics | 2007 |
| T T Goats Limited | Agriculture & fishing | 2017 |
| T&B Holdings Ltd | Financial services | 2026 |
| T&C Warwick Limited | Wholesale & retail | 2016 |
| T&J Burgers Ltd | Hospitality | 2021 |
| T&M Nails Ltd | Other services | 2022 |
| T.U.S.Midlands Limited | Construction | 2006 |