| SIL Spedition Ltd | Transport & logistics | 2026 |
| Silotek Films Limited | Arts & recreation | 2023 |
| Silver Dragon Ltd | Real estate | 2020 |
| Silver Empire Ltd | Wholesale & retail | 2022 |
| Silver Security & Facilities Management Ltd | Administrative & support | 2015 |
| Silverbrook Developments Limited | Real estate | 1995 |
| Sima Properties (Stay in My Accommodation) Ltd | Real estate | 2025 |
| Simple Stuff Works Associates Ltd | Manufacturing | 2015 |
| SIMPLY4YOU Ltd | Wholesale & retail | 2018 |
| Singh Associate WM Limited | Hospitality | 2025 |
| Sinica Limited | Information & communication | 2020 |
| Sippitts Property Ltd | Real estate | 2025 |
| Sirius Financial Planning Limited | Financial services | 2010 |
| Sittles Farm Flying Club Limited | Arts & recreation | 2003 |
| Situ Construction Limited | Construction | 2016 |
| Situ Energy Ltd | Construction | 2024 |
| Situ Interiors Ltd | Construction | 2016 |
| Situ Mechanical & Electrical Ltd | Construction | 2016 |
| Situ Total Building Solutions Ltd | Construction | 2014 |
| SIX Star Electrical Limited | Construction | 2021 |
| Sixfood Ltd | Hospitality | 2022 |
| SJ Evolution Ltd | Real estate | 2023 |
| SJD Leisure and Event Management Ltd | Administrative & support | 2004 |
| SJS International Trading Ltd | Wholesale & retail | 2025 |
| SJT Build Cleans Ltd | Other services | 2022 |
| SJW Building Contracts Ltd | Construction | 2015 |
| SJW Decorating Contractors Ltd | Construction | 2019 |
| Sk-K 1A Ltd | Other services | 2024 |
| Skaka Bistro Limited | Hospitality | 2026 |
| SKE Direct Sales Ltd | Wholesale & retail | 2012 |
| Skillsloop Ltd | Education | 2019 |
| Skimline Ltd | Administrative & support | 2020 |
| Skimline Plastering & Rendering Services Limited | Construction | 2017 |
| Skintonicallure Limited | Other services | 2013 |
| Skip Link Ltd | Administrative & support | 2025 |
| Skoot Eco Ltd | Professional & scientific | 2018 |
| Skylark Farm (Sutton Coldfield) Limited | Agriculture & fishing | 2017 |
| Skyward Ventures Limited | Arts & recreation | 2024 |
| SLM Engineering Solutions Ltd | Administrative & support | 2015 |
| SLN IT Consultancy Limited | Information & communication | 2017 |
| Slrm Holdings Ltd | Real estate | 2025 |
| SLY69 Ltd | Transport & logistics | 2019 |
| SM Bowley Ltd | Manufacturing | 2023 |
| SM Dance Academy Limited | Arts & recreation | 2026 |
| SM Legal Services Limited | Professional & scientific | 2006 |
| Smart Build Consultancy Limited | Construction | 2026 |
| Smart Consulting Group Limited | Construction | 2021 |
| Smart Fit Joinery Ltd | Manufacturing | 2019 |
| Smart Inheritance Solutions Ltd | Financial services | 2006 |
| Smart Makeovers Ltd | Wholesale & retail | 2023 |
| Smart Performance Group Ltd | Manufacturing | 2015 |
| Smart Prep Limited | Transport & logistics | 2023 |
| Smart Vintage Limited | Wholesale & retail | 2026 |
| Smartwheel Driving Academy Limited | Education | 2025 |
| Smashed Limited | Extraterritorial | 2002 |
| SME Transport Services Ltd | Transport & logistics | 2026 |
| Smethwick Station Development Ltd | Construction | 2026 |
| Smifinn Technologies Ltd | Information & communication | 2026 |
| Smiley Carpets Limited | Construction | 2019 |
| Smith and Family Electrical Ltd | Construction | 2025 |
| SMJ Developments Ltd | Real estate | 2025 |
| Snack Zone Ltd | Wholesale & retail | 2025 |
| Snap-Dragon-Aerial Ltd | Professional & scientific | 2021 |
| Snowdome Catering Ltd | Hospitality | 2025 |
| Snowdome Corporation Limited | Arts & recreation | 2022 |
| Snowdome Group Limited | Arts & recreation | 2006 |
| Snowdome Holdings Limited | Arts & recreation | 2000 |
| Snowdome Incorporated Limited | Financial services | 2023 |
| Snowdome Limited | Arts & recreation | 1999 |
| Snowdome Swim & Fitness Limited | Arts & recreation | 2007 |
| Snug and Snooze Ltd | Health & social care | 2026 |
| Sobarro Ltd | Transport & logistics | 2022 |
| Social & Foto Limited | Professional & scientific | 2022 |
| Sodeca Fans UK Limited | Wholesale & retail | 2016 |
| Softext Limited | Information & communication | 2012 |
| Software Selection Services Limited | Information & communication | 2025 |
| Soho 9 Limited | Hospitality | 2024 |
| Solid Drive Ltd | Wholesale & retail | 2025 |
| Solihull Golf Club Limited | Professional & scientific | 1999 |
| Solihull Storm IHC Ltd | Arts & recreation | 2025 |
| Solucient Limited | Information & communication | 2019 |
| SOLUTION17 Ltd | Information & communication | 2018 |
| Solware Limited | Wholesale & retail | 1999 |
| Solwy Limited | Administrative & support | 2018 |
| Somerset White Limited | Professional & scientific | 1999 |
| Sona Property Investments Limited | Real estate | 2023 |
| Sona Property Limited | Real estate | 2023 |
| Sonecc Freight Ltd | Transport & logistics | 2013 |
| Soonas Solutions Limited | Administrative & support | 2021 |
| Sotersoft Ltd | Information & communication | 2012 |
| Soudal (UK) Limited | Wholesale & retail | 1996 |
| Soundzest Software Limited | Information & communication | 2011 |
| Source 9 Limited | Wholesale & retail | 2016 |
| Source Compliance Limited | Professional & scientific | 2024 |
| Source.Me Limited | Administrative & support | 2024 |
| South Staffordshire Paper Products Limited | Manufacturing | 2006 |
| Southern Golf Limited | Construction | 2014 |
| Southlands Construction Services Limited | Construction | 2003 |
| Sovereign Motor Company Limited | Wholesale & retail | 2005 |
| SP Finishes Ltd | Construction | 2021 |