| Seaton Hire Limited | Construction | 1979 |
| SEB Furniture Limited | Wholesale & retail | 2019 |
| SEB James Ltd | Professional & scientific | 2025 |
| Second City Interiors Limited | Construction | 2018 |
| Second Life Financial Planning Limited | Professional & scientific | 2006 |
| Security Training 4 U Limited | Administrative & support | 2025 |
| Sefa (Publications) Limited | Hospitality | 1964 |
| Segregation of Recyclables Tamworth Limited | Extraterritorial | 2004 |
| Sehaj Fish Bar Ltd | Hospitality | 2026 |
| Sekida Limited | Wholesale & retail | 2024 |
| Sel(Midlands) Ltd | Real estate | 2012 |
| Selectionwise Limited | Information & communication | 2023 |
| Selfe Assessment Ltd | Professional & scientific | 2025 |
| Sell My Car Ltd | Wholesale & retail | 2022 |
| Sellena Ltd | Hospitality | 2025 |
| Sellorenne Ltd | Transport & logistics | 2026 |
| Senior Care Tamworth Limited | Other services | 2015 |
| Senses of Siam Limited | Other services | 2022 |
| Sentra Cyber Security Limited | Information & communication | 2024 |
| Sentrametric Technology Solutions Ltd | Information & communication | 2026 |
| Sequel Barbershop Ltd | Other services | 2023 |
| Seraphim.Hq Ltd | Other services | 2025 |
| Servemedics Limited | Health & social care | 2025 |
| Service Search Directory Ltd | Wholesale & retail | 2025 |
| Setton Impex S.A. Limited | Administrative & support | 2010 |
| Seven Mile Development Ltd | Professional & scientific | 2025 |
| Seventh Wave Media Ltd. | Information & communication | 2000 |
| SEVENTY8 Consulting Limited | Professional & scientific | 2025 |
| Severn Amenity Services Limited | Wholesale & retail | 2012 |
| Sevon Limited | Construction | 2012 |
| SG Electrical and Mechanical Services Limited | Manufacturing | 2015 |
| SG Family Homes Ltd | Real estate | 2024 |
| SGF Property Services Ltd | Real estate | 2026 |
| SGM Magnetics UK Limited | Manufacturing | 2010 |
| Shadow Lord Agency Ltd | Professional & scientific | 2025 |
| Shake & Take Limited | Hospitality | 2026 |
| Shakeel Ltd | Health & social care | 2024 |
| Shakespeare Studley Limited | Hospitality | 2012 |
| Shammah Consultancy Services Limited | Administrative & support | 2024 |
| Shamrock Haulage Ltd | Transport & logistics | 2014 |
| Shanru Limited | Real estate | 2026 |
| Shark Hire and Attachments Limited | Administrative & support | 2021 |
| Sharon Louca Limited | Professional & scientific | 2014 |
| Sharp Group Holdings Limited | Financial services | 2025 |
| Sharp Mechanical Limited | Construction | 2025 |
| Sharp Renovations Limited | Real estate | 2023 |
| Sharp Technical Ltd | Energy | 2015 |
| Shaun’S Kids Parties Ltd | Arts & recreation | 2025 |
| Shaw Stairs Limited | Manufacturing | 1999 |
| Shawcross Holdings Limited | Real estate | 2020 |
| Shear Success (Midlands) Limited | Other services | 1998 |
| Sheard Commerce Limited | Wholesale & retail | 2026 |
| Shears Construction Ltd | Construction | 2023 |
| Shears Plumbing Heating & GAS Ltd | Administrative & support | 2017 |
| Sheasby Jones Music Limited | Arts & recreation | 2018 |
| Sheepy Road Management Company Limited | Administrative & support | 1989 |
| Sheldrick Creative Limited | Professional & scientific | 2014 |
| Shellfast Finance Limited | Hospitality | 1984 |
| Shenwick Recruitment Limited | Administrative & support | 2014 |
| Sheppard FM Solutions Ltd | Administrative & support | 2019 |
| Sherlock & Sherlock Medical Ltd | Health & social care | 2025 |
| Sherlock Hynes Limited | Administrative & support | 2012 |
| Sherriff’S EMS Ltd | Health & social care | 2025 |
| Shields Environmental Group (Holdings) Ltd. | Professional & scientific | 2015 |
| Shields Environmental Group Ltd | Information & communication | 1979 |
| Shields Environmental Investment (Holdings) Limited | Professional & scientific | 2015 |
| Shields Environmental Limited | Information & communication | 1979 |
| Shimla Medical Services Limited | Health & social care | 2017 |
| Shimna Property Limited | Real estate | 2015 |
| Shiney Limited | Health & social care | 2010 |
| Shipley Estates Limited | Arts & recreation | 1994 |
| Shipley Loans Limited | Financial services | 2010 |
| Shiraz & Sons Limited | Health & social care | 2005 |
| Shire Asset Finance Limited | Extraterritorial | 2017 |
| Shire Business Group Limited | Financial services | 2011 |
| Shire County Paving Limited | Construction | 2011 |
| Shire Green Developments Ltd | Construction | 2024 |
| Shire Insurance Services Limited | Financial services | 2009 |
| Shire Invoice Finance Limited | Financial services | 2010 |
| Shire Lead Generators Limited | Extraterritorial | 2010 |
| Shire Leasing PLC | Administrative & support | 1990 |
| Shire Legal Ltd | Professional & scientific | 2022 |
| Shire Professional Services Ltd. | Extraterritorial | 1991 |
| Shire Recoveries Limited | Administrative & support | 2006 |
| Shire Securities Limited | Financial services | 2006 |
| Shires Florist Limited | Wholesale & retail | 2025 |
| Shoptions Associates Limited | Information & communication | 2019 |
| Shore & SON Property Management Limited | Real estate | 2003 |
| Short Stays Property Ltd | Real estate | 2022 |
| Shorty's Transport Limited | Transport & logistics | 2025 |
| Shree Hari AUM Ltd | Wholesale & retail | 2015 |
| Shuut Limited | Information & communication | 2014 |
| Siam Food Shop Ltd | Wholesale & retail | 2020 |
| SIG Enterprises Ltd | Professional & scientific | 2025 |
| Sigma Link Ltd | Professional & scientific | 2024 |
| Signasaurus Limited | Professional & scientific | 2012 |
| Signature Threads Ltd | Wholesale & retail | 2025 |
| Signedyours Ltd | Wholesale & retail | 2026 |
| Signpost Media Limited | Administrative & support | 2018 |
| Sigourney Whitesel Ltd | Information & communication | 2019 |