| S Aesthetics Limited | Health & social care | 2017 |
| S C V Services Limited | Administrative & support | 2009 |
| S D Decorating & Maintenance Ltd | Construction | 2025 |
| S D Hughes Electrical Solar PV Limited | Construction | 2022 |
| S D Leisure Limited | Arts & recreation | 2003 |
| S J Rosenbach & Sons Transport Ltd | Transport & logistics | 2011 |
| S J Smith & SON Landscape and Tree Services Ltd | Administrative & support | 2023 |
| S K B Shepherds Kitchens & Bedrooms Limited | Construction | 2007 |
| S K Store River Side Limited | Wholesale & retail | 2015 |
| S L F Limited | Wholesale & retail | 2025 |
| S M Architectural Limited | Professional & scientific | 2012 |
| S M Dunne Civil Engineering Ltd | Construction | 2015 |
| S Moss Roofing Ltd | Construction | 2024 |
| S W Bostock Limited | Agriculture & fishing | 1998 |
| S&A Creative Ltd | Arts & recreation | 2021 |
| S&Jc Processing Ltd | Extraterritorial | 2012 |
| S&L Day Services Limited | Health & social care | 2023 |
| S. Woolley Livestock Limited | Agriculture & fishing | 2023 |
| S.Beale Investments Limited | Real estate | 2024 |
| S.Bealeservices Limited | Energy | 2013 |
| S.C. Groundwork Contractors Limited | Administrative & support | 1999 |
| S.C. Services (Tamworth) Limited | Wholesale & retail | 2024 |
| S.D. Hughes Electrical Services Limited | Construction | 2015 |
| S.H Entertainment Ltd | Hospitality | 2024 |
| S.H.Joinery Limited | Construction | 2005 |
| S.I.P. Software Consultancy Limited | Information & communication | 2002 |
| S.Newton Groundworks Ltd | Construction | 2025 |
| Saavaani Properties Ltd | Real estate | 2024 |
| Sade Holdings Ltd | Real estate | 2021 |
| Sadler Heating Ltd | Construction | 2014 |
| SAF Leasing Limited | Administrative & support | 2008 |
| Safenest Technologies Ltd | Information & communication | 2025 |
| Safety & Risk Compliance Limited | Professional & scientific | 2017 |
| Safety at Heart Ltd | Education | 2021 |
| Safety Compliance Consultants Ltd | Administrative & support | 2024 |
| Safety Engineering Association Ltd | Professional & scientific | 2018 |
| SAG Restaurant Ltd | Hospitality | 2025 |
| Sage Accounting Limited | Professional & scientific | 2015 |
| Sage Centre of Wellness Ltd | Health & social care | 2025 |
| Salahs Retail Ltd | Wholesale & retail | 2024 |
| Salon Iris Ltd | Information & communication | 2006 |
| Salt and Pepper Media Ltd | Information & communication | 2023 |
| Salus Global Training Ltd | Education | 2025 |
| SAM Bentley Ltd | Information & communication | 2021 |
| Samroto Limited | Real estate | 2009 |
| Sanasafinas Fried Ltd | Hospitality | 2026 |
| Sanders Group Ltd | Administrative & support | 2018 |
| Sanders Property Maintenance & Home Improvements Ltd | Construction | 2025 |
| Sandfords Catering Ltd | Hospitality | 2026 |
| Sandhu Residential Ltd | Administrative & support | 2025 |
| Sandra Ghenassia Productions Limited | Information & communication | 2025 |
| Sandy Court Management Ltd | Households | 2006 |
| Sandy Mount Studio Ltd | Professional & scientific | 2025 |
| Sangamo Limited | Manufacturing | 2002 |
| Santova Corporate Services UK Ltd | Financial services | 2020 |
| Santova Express United Kingdom Limited | Transport & logistics | 1990 |
| Santova Logistics Limited | Transport & logistics | 1989 |
| Sanvi Food & Wine Ltd | Wholesale & retail | 2026 |
| Sara-Haircare Ltd | Wholesale & retail | 2025 |
| Saragea Ltd | Transport & logistics | 2024 |
| Sarah Swift Limited | Financial services | 2025 |
| Sarn Medical Limited | Health & social care | 2013 |
| SAS Great Limited | Construction | 2025 |
| SAS Managed Services Ltd | Administrative & support | 2017 |
| SAS Projects & Consultancy Ltd | Administrative & support | 2021 |
| SAS Training Ltd | Education | 2026 |
| Sas-Ms Events Ltd | Other services | 2026 |
| Sas-Ms Group Holdings Ltd | Financial services | 2026 |
| Sas-Ms Property's Ltd | Real estate | 2025 |
| Sassy Strolls Ltd | Agriculture & fishing | 2022 |
| Satvir Estate Ltd | Real estate | 2024 |
| Savvy Spirits Ltd | Manufacturing | 2022 |
| SB Lettings Ltd | Real estate | 2025 |
| SBC Property Limited | Arts & recreation | 2002 |
| SC Laser Ltd | Manufacturing | 2025 |
| SC Plumbing & GAS Ltd | Construction | 2022 |
| Scarlet Panther Limited | Administrative & support | 2024 |
| Schoeller Allibert Limited | Manufacturing | 2011 |
| Scholar Education Talent Ltd | Administrative & support | 2024 |
| Schuller Property Ltd | Real estate | 2026 |
| Schweizer Electronic Limited | Administrative & support | 2005 |
| Sci-Temps Limited | Administrative & support | 1997 |
| SCJ Developments Limited | Real estate | 2024 |
| Scolmore (International) Limited | Wholesale & retail | 1990 |
| Score Staffing Solutions Limited | Administrative & support | 2025 |
| Scott Motor Company Ltd | Wholesale & retail | 2009 |
| Scubasheets Limited | Wholesale & retail | 2020 |
| SD Leisure Tamworth Limited | Arts & recreation | 2004 |
| SD Motor Group Limited | Wholesale & retail | 2025 |
| SD PMU Limited | Other services | 2018 |
| SDC Property Development Ltd | Real estate | 2020 |
| SDR Ashby Limited | Extraterritorial | 2008 |
| SDR Tamworth Limited | Professional & scientific | 2021 |
| SDS Plus Limited | Information & communication | 2025 |
| SDT Electrical Services Ltd | Construction | 2015 |
| Sdtt Consultancy Ltd | Health & social care | 2020 |
| Seagrave-Consultancy Ltd | Professional & scientific | 2017 |
| Seahorse Films Ltd | Information & communication | 2024 |
| Seams and Dreams Limited | Other services | 2014 |
| Seaton Heating & Engineering Services Limited | Wholesale & retail | 1974 |