| Speer Group Ltd | Administrative & support | 2026 |
| Spencer the Fencer Limited | Administrative & support | 2021 |
| SPF Window Cleaning Services Limited | Other services | 2017 |
| SPG Landscape and Building Services Limited | Administrative & support | 2021 |
| Sphere Admin Solutions Limited | Administrative & support | 2017 |
| Sphere Therapy Group Ltd | Health & social care | 2014 |
| Spice Inn Balti Sutton Ltd | Hospitality | 2024 |
| Spice Inn Ltd | Hospitality | 2025 |
| Spice Nation B47 Ltd | Hospitality | 2023 |
| Spidans Strides Ltd | Health & social care | 2025 |
| Spin to WIN Limited | Arts & recreation | 2025 |
| Spine Complete Care Ltd | Health & social care | 2017 |
| Spinney Estates Limited | Real estate | 2021 |
| SPJ (Polesworth) Limited | Construction | 2019 |
| Splash Design Birmingham Ltd | Professional & scientific | 2018 |
| Splash Interiors Limited | Construction | 2005 |
| Spmg Estates Limited | Real estate | 2019 |
| Sport Bits UK Limited | Wholesale & retail | 2024 |
| Sporting U Limited | Public administration | 2025 |
| Sportology Limited | Wholesale & retail | 2005 |
| Spot Aviation Limited | Transport & logistics | 2023 |
| Spot on 83 Ltd | Real estate | 2025 |
| Spotbuyer Holdings Ltd | Financial services | 2020 |
| Spotbuyer Limited | Wholesale & retail | 2008 |
| Spotcover Limited | Professional & scientific | 2013 |
| Spotland Bridge Funeral Services Limited | Other services | 2005 |
| Spotlight Academy of Dance Ltd | Education | 2025 |
| Spotlight Shows Ltd | Information & communication | 2023 |
| Spoton Events Ltd | Information & communication | 2018 |
| Spring Lane Service Station (Erdington) Ltd. | Wholesale & retail | 1998 |
| Springfield Court (Sutton Coldfield) RTM Company Limited | Households | 2008 |
| Springfield Maintenance Company Limited | Households | 1967 |
| Springton Limited | Other services | 2024 |
| Sprx Limited | Wholesale & retail | 2022 |
| SPT Online Training Ltd | Professional & scientific | 2023 |
| SPY Equipment UK Limited | Extraterritorial | 2011 |
| SQ Thai Massage UK Ltd | Other services | 2023 |
| Square PEG Activities Limited | Other services | 2018 |
| Square Pizza Reddish Ltd | Hospitality | 2019 |
| Squarebee Limited | Information & communication | 2006 |
| Squirrel Walk Residents Association Limited | Households | 2008 |
| Squishy | Other services | 2014 |
| SR Automotive Limited | Professional & scientific | 2003 |
| SR BLT Venture Ltd | Real estate | 2026 |
| SR Management & Consultancy Ltd | Wholesale & retail | 2013 |
| SR Medical Limited | Health & social care | 2016 |
| SR22T Ltd | Administrative & support | 2023 |
| Srana Properties Limited | Real estate | 2022 |
| SRI Pinky Sounds Ltd | Arts & recreation | 2022 |
| SRI Selli Amman Limited | Construction | 2014 |
| SRI Selli Amman Properties Ltd | Extraterritorial | 2016 |
| Sricons Limited | Real estate | 2018 |
| SRR Premiere Property Ltd | Real estate | 2025 |
| SS Coventry Limited | Construction | 2013 |
| SS UK Property Management Limited | Administrative & support | 2024 |
| SSA Motors Ltd | Wholesale & retail | 2022 |
| SSB Trucking Ltd | Transport & logistics | 2015 |
| Ssgsj Ltd | Extraterritorial | 2022 |
| SSH Construction Ltd | Construction | 2011 |
| SSH Properties Limited | Real estate | 2016 |
| SSH Property Group Ltd | Real estate | 2017 |
| SSP Events Ltd | Arts & recreation | 2026 |
| SSP Invest Ltd | Real estate | 2024 |
| Ssrr Properties Ltd | Real estate | 2025 |
| SSS (Birmingham) Limited | Wholesale & retail | 2011 |
| SSS Elite Limited | Real estate | 2026 |
| SSS Property Development Limited | Construction | 2023 |
| ST Martins Projects Ltd | Manufacturing | 2014 |
| ST Response Electrical Ltd | Construction | 2025 |
| ST Selection Ltd | Administrative & support | 2012 |
| St-Motors-Uk Ltd | Wholesale & retail | 2022 |
| Stable 5 Studios Limited | Other services | 2024 |
| Stackwood (Management) Limited | Extraterritorial | 1972 |
| Staffordshire Technology Park Management Company Limited | Real estate | 2003 |
| Stage and Exhibition Solutions Ltd | Administrative & support | 2018 |
| Stagonset Limited | Extraterritorial | 2010 |
| Stal Investments Limited | Real estate | 2019 |
| Stamp Duty Advisory Services Limited | Professional & scientific | 2021 |
| Standishgate Investments Ltd | Financial services | 2026 |
| Stanfield Care Services Limited | Health & social care | 2012 |
| Stanmor Floors Limited | Construction | 1977 |
| Stansfield Group Limited | Wholesale & retail | 1983 |
| Stantondrew Properties Ltd | Real estate | 2014 |
| Stanway & Garnett Funeral Service Limited | Extraterritorial | 1973 |
| Star Hand Car Wash (UK) Ltd | Wholesale & retail | 2014 |
| Starfish (PYE Green) Limited | Hospitality | 2021 |
| Starfish Properties (Leicester) Limited | Hospitality | 2010 |
| Starmintz Ltd | Manufacturing | 2023 |
| START2SCORE Limited | Education | 2025 |
| Staying Sunny Investments Limited | Real estate | 2019 |
| Stayingsunny Limited | Wholesale & retail | 2016 |
| STB Consultancy Solutions Ltd | Information & communication | 2010 |
| STC-24 Ltd | Health & social care | 2019 |
| Steadman Real Estate Limited | Real estate | 2023 |
| Stealth Vehicle Solutions Limited | Wholesale & retail | 2020 |
| Steel 9 Fabrications Ltd | Manufacturing | 2022 |
| Steeles Carpets Ltd | Extraterritorial | 2010 |
| Stella Maris Management Company Limited | Real estate | 2001 |
| Stellar Rentals Limited | Real estate | 2022 |
| Stem Travel Ltd | Administrative & support | 2023 |