| Smoke Bazar Ltd | Wholesale & retail | 2021 |
| Smoov Designs Limited | Extraterritorial | 2003 |
| SMQ Services Limited | Financial services | 1998 |
| SMR Global Ltd | Wholesale & retail | 2013 |
| SMS Tooreen Limited | Arts & recreation | 2021 |
| SMS Walsall Limited | Real estate | 2021 |
| Smscglobal Ltd | Information & communication | 2014 |
| SN Dwellings Ltd | Real estate | 2024 |
| SN Medicare Ltd | Health & social care | 2022 |
| Snap Digital Ltd | Information & communication | 2018 |
| Sndosaland Ltd | Hospitality | 2025 |
| Sniffers Pets Ltd | Professional & scientific | 2024 |
| Snob Academy Ltd | Education | 2021 |
| Snob Events Limited | Hospitality | 2013 |
| Snowball Marketing Ltd | Wholesale & retail | 2014 |
| SOA Limited | Professional & scientific | 2015 |
| Social Work Experts Limited | Professional & scientific | 2012 |
| Sockssoxsocks Ltd | Wholesale & retail | 2023 |
| Socmedia Limited | Information & communication | 2022 |
| Soft Test Solutions Limited | Information & communication | 2015 |
| Softecbee Limited | Information & communication | 2023 |
| Software Solution Design Ltd | Information & communication | 2012 |
| Sohaib Hameed and Co Ltd | Professional & scientific | 2019 |
| Sohail Raja Limited | Health & social care | 2018 |
| Sohal Imports Ltd | Wholesale & retail | 2006 |
| Sohl Ltd | Real estate | 1999 |
| Solaceo Ltd | Health & social care | 2026 |
| Solar Systems 365 Ltd | Construction | 2019 |
| Solara Skin Ltd | Other services | 2025 |
| Solid Global Limited | Health & social care | 2013 |
| Solid Global Realty Ltd | Real estate | 2021 |
| Solidarc Limited | Professional & scientific | 2025 |
| Solihull Meat Company Limited | Administrative & support | 1974 |
| Solihull Paws Ltd | Agriculture & fishing | 2018 |
| Solihull WOW Limited | Education | 2017 |
| Solutions Publishing (Midlands) Limited | Information & communication | 2016 |
| SOLUTIONS2 (UK) Ltd | Administrative & support | 2001 |
| Solux Energy Ltd | Construction | 2026 |
| Solva Consults Ltd | Information & communication | 2021 |
| Soma Fitness Limited | Health & social care | 2013 |
| Somerset Care Home Ltd | Health & social care | 2025 |
| Sona Analytics Limited | Administrative & support | 2023 |
| Sona Silver Limited | Wholesale & retail | 2003 |
| Sonamy Ltd | Professional & scientific | 2024 |
| Songbug Ltd | Information & communication | 2025 |
| Sonus Capital Ltd | Financial services | 2024 |
| Soom Ltd | Real estate | 2020 |
| Sophia R Chadha Ltd | Health & social care | 2024 |
| Sophie Durston Limited | Arts & recreation | 2016 |
| Sophies Pizza & Pasta Ltd | Hospitality | 2026 |
| Sorelle & Co Studio Limited | Other services | 2026 |
| Sori Limited | Hospitality | 2024 |
| Sorion Developments Limited | Extraterritorial | 2004 |
| Sorion Limited | Professional & scientific | 2004 |
| SOS Media Limited | Professional & scientific | 2020 |
| Soul Food (International) Ltd | Hospitality | 2021 |
| Soul Star Platforms Limited | Construction | 2025 |
| Sound Control DJS Ltd. | Arts & recreation | 2012 |
| Sound!Start Phonics Ltd | Administrative & support | 2020 |
| Source Watches Limited | Wholesale & retail | 2006 |
| Sousa Palace Ltd | Wholesale & retail | 2025 |
| South Asian Film Festival UK Ltd | Arts & recreation | 2026 |
| South London and Southern Counties Cremation Society Limited(The) | Extraterritorial | 1938 |
| South London Crematorium Co Limited(The) | Extraterritorial | 1936 |
| South West Glass (Wilts) Limited | Manufacturing | 2000 |
| Southerns & Carter Ltd | Extraterritorial | 1999 |
| Southfield Way Management Company Limited | Administrative & support | 2015 |
| Southpark Ltd | Hospitality | 2023 |
| Southwinds Limited | Other services | 1993 |
| Sovereign Consultancy Ltd | Professional & scientific | 2024 |
| Sovereign House (1-7) RTM Company Ltd | Households | 2018 |
| Sovereign Key Ltd | Wholesale & retail | 2025 |
| Sovereigns Management Limited | Households | 2003 |
| SP Advisory Limited | Professional & scientific | 2016 |
| SP Bookkeeping & Associated Services Ltd | Professional & scientific | 2020 |
| SP Customer Insight Ltd | Professional & scientific | 2017 |
| SP Investment Holdings Ltd | Real estate | 2024 |
| SP Property & Lettings Ltd | Real estate | 2023 |
| SP Software Development Ltd | Information & communication | 2021 |
| Space MAN Construction Ltd | Construction | 2025 |
| Space Studio Birmingham Limited | Arts & recreation | 2026 |
| Spacebound Studios Ltd | Information & communication | 2021 |
| Spacebrights Limited | | 1988 |
| Spaces 4 ALL Limited | Arts & recreation | 2024 |
| Spaces by Dean Ford Limited | Construction | 2011 |
| Sparkbyte Ltd | Information & communication | 2025 |
| Sparkle Wash Ltd | Administrative & support | 2025 |
| Sparkling Diamond Cleaning Services Limited | Administrative & support | 2025 |
| Sparks Consultancy & Interim Management Limited | Professional & scientific | 2019 |
| Sparrow Consulting and Services PVT Ltd | Information & communication | 2020 |
| Spatc Limited | Education | 2025 |
| SPB Building Design Limited | Professional & scientific | 2026 |
| SPD Commercial Limited | Professional & scientific | 2008 |
| Special Application Fire Equipment Limited | Manufacturing | 2011 |
| Specialist Performance Vehicles Limited | Wholesale & retail | 2019 |
| SPECIALISTCARE4U Ltd | Health & social care | 2020 |
| Spectre Restaurants Limited | Hospitality | 2015 |
| Spectro (UK) Limited | Construction | 2014 |
| Spectrum Electrical & Maintenance Ltd | Manufacturing | 2011 |
| Speech and Language Therapy West Midlands Ltd | Health & social care | 2024 |