| Ronan Engineering Limited | Manufacturing | 1977 |
| Ronktad Afro Store Ltd | Wholesale & retail | 2025 |
| Roof and Driveway Revive Limited | Construction | 2026 |
| Roofing Services North East Ltd | Construction | 2024 |
| Rooted Venture Limited | Wholesale & retail | 2026 |
| Roothive Limited | Administrative & support | 2026 |
| Rope Access Solutions Ltd | Construction | 2019 |
| Roper J Renewables Ltd | Professional & scientific | 2026 |
| Ropezilla Limited | Professional & scientific | 2013 |
| Rorack Shipping Ltd | Transport & logistics | 2017 |
| Roseberry Roofing Limited | Construction | 2015 |
| Rosh Consett Ltd | Hospitality | 2025 |
| Ross Maritime Services Limited | Transport & logistics | 2019 |
| Rossie Place Investments Ltd | Real estate | 2020 |
| Rostami's Pizzas & Grills Ltd | Hospitality | 2018 |
| Rotem International Limited | Agriculture & fishing | 2017 |
| Rothbury Associates Limited | Construction | 2009 |
| Rothes Group Ltd | Transport & logistics | 2025 |
| Rough Diamond Entertainment Ltd | Arts & recreation | 2015 |
| Rowburn Construction Limited | Construction | 2017 |
| Rowlandson Terrace Ltd | Education | 2022 |
| Rowshuni Express Ltd | Hospitality | 2025 |
| ROX Motor Company Limited | Wholesale & retail | 2024 |
| Roxburgh Block Management Limited | Real estate | 2022 |
| RP Audio Ltd | Arts & recreation | 2019 |
| RPO Projects Ltd | Real estate | 2020 |
| RR Energy Services Ltd | Professional & scientific | 2025 |
| RR Vehicle Services Ltd | Wholesale & retail | 2023 |
| RS Bathrooms Ltd | Construction | 2025 |
| RS Commercials & Cars Limited | Wholesale & retail | 2024 |
| RS Transport 2025 Ltd | Transport & logistics | 2025 |
| RSC Redstar Clothing Limited | Manufacturing | 2012 |
| Rsdj Limited | Real estate | 2019 |
| Rsls Property Ltd | Real estate | 2002 |
| Rsvk Limited | Health & social care | 2018 |
| Rt-It and General Ltd | Other services | 2016 |
| RTC North | Professional & scientific | 1989 |
| RTC North Holdco Limited | Financial services | 2026 |
| RTC North Trustee Limited | Professional & scientific | 2026 |
| RTC Property Maintenance Limited | Wholesale & retail | 1992 |
| Rubiheat GAS Plumbing and Heating Ltd | Construction | 2024 |
| Rubix Management Limited | Professional & scientific | 2012 |
| Ruby Constructions (North East) Ltd | Construction | 2022 |
| Ruby Property Lets Ltd | Real estate | 2022 |
| Rubz Catering Limited | Hospitality | 2025 |
| Rufus Creative Design Limited | Extraterritorial | 2015 |
| Ruhe North East Ltd | Hospitality | 2023 |
| Russell Foster Tyne and Wear Sports Foundation | Arts & recreation | 1997 |
| Russo Ristorante Ltd | Hospitality | 2020 |
| Rustica Hospitality Limited | Hospitality | 2019 |
| Rustica Inn Ltd | Hospitality | 2024 |
| Rvvc Limited | Financial services | 2017 |
| RWI Ryhope Ltd | Hospitality | 2025 |
| RY Consulting Services Limited | Professional & scientific | 2024 |
| Ryan Business Network Limited | Professional & scientific | 2016 |
| Ryan Land and Property Ltd | Real estate | 2020 |
| Ryan Maritime Services Limited | Transport & logistics | 2021 |
| Ryan Offshore Limited | Transport & logistics | 2009 |
| Ryan Wood Consulting Limited | Arts & recreation | 2024 |
| Rybeda Group Ltd | Professional & scientific | 2023 |
| Rye's Bolting Ltd | Construction | 2024 |
| Ryhope Art and Craft Studio CIC | Education | 2018 |
| Ryhope Boxing and Fitness CIC | Arts & recreation | 2026 |
| Ryhope Boxing Gym Community Interest Company | Arts & recreation | 2014 |
| Ryhope Colliery Welfare FC CIC | Arts & recreation | 2025 |
| Ryhope Infant School Academy | Education | 2014 |
| Ryhope Tandoori Ltd | Hospitality | 2025 |
| Ryhope Village & District Club,Limited(The) | Hospitality | 1903 |
| Ryol Pizza Sunderland Ltd | Hospitality | 2024 |
| RZ Property Group Ltd | Real estate | 2025 |
| S & a Leisure Ltd | Hospitality | 2017 |
| S & B Pharma Limited | Wholesale & retail | 2018 |
| S & JAY Properties Ltd | Real estate | 2022 |
| S Armstrong’S Joinery Ltd | Manufacturing | 2026 |
| S B C 168 Ltd | Hospitality | 2024 |
| S B Harris Limited | Information & communication | 2014 |
| S Brothers Transport Ltd | Manufacturing | 2024 |
| S E Gill Chemist Limited | Wholesale & retail | 2008 |
| S E Harris Consulting Ltd | Professional & scientific | 2024 |
| S Hartshorne Limited | Manufacturing | 2014 |
| S Jackson Ltd | Information & communication | 2019 |
| S K Venture Solutions Limited | Real estate | 2017 |
| S Lloyd Consulting Ltd | Professional & scientific | 2010 |
| S M Blade Services Ltd | Manufacturing | 2017 |
| S Mann Holdings Limited | Financial services | 2023 |
| S R Achievers Ltd | Wholesale & retail | 2013 |
| S Taylor Sales Consulting Ltd | Professional & scientific | 2021 |
| S to F Constructions Ltd | Construction | 2025 |
| S&D Financial Services Limited | Financial services | 2020 |
| S&G Recruitment Solutions Ltd | Administrative & support | 2019 |
| S&Id Limited | Professional & scientific | 2025 |
| S&N.Diamond Ltd | Hospitality | 2021 |
| S&P Hunter Properties Ltd | Real estate | 2018 |
| S&S Premier Events Limited | Wholesale & retail | 2024 |
| S.B Rentals (NE) Ltd | Real estate | 2025 |
| S.B Travel (NE) Ltd | Transport & logistics | 2026 |
| S.B.T.C. Ltd | Transport & logistics | 2026 |
| S.Britton Testing Services Ltd | Manufacturing | 2016 |
| S.E.M. Alloy Wheel Specialists Ltd | Wholesale & retail | 2019 |
| S.I.E. Industrial Limited | Manufacturing | 1982 |