| S.N Evans Limited | Wholesale & retail | 2023 |
| S.Shroff Limited | Health & social care | 2025 |
| S.W.E Limited | Construction | 2016 |
| SA Access Ltd | Construction | 2012 |
| SA Trending Ltd | Wholesale & retail | 2019 |
| Sa&Ro Ltd | Hospitality | 2025 |
| Saaaz Ltd | Wholesale & retail | 2016 |
| Saba Malik Co Ltd | Financial services | 2025 |
| Sabeer Store Ltd | Wholesale & retail | 2026 |
| Sacred Sounds CIC | Health & social care | 2022 |
| Sadie the BRA Lady (Sunderland) Ltd | Wholesale & retail | 2016 |
| Safe Seal North East Limited | Construction | 2015 |
| Safe Strip UK Limited | Water & waste | 2007 |
| Safelysent Logistics Limited | Transport & logistics | 2026 |
| Safeness Safety Support Limited | Public administration | 2020 |
| Safeshield Door Systems Ltd | Administrative & support | 2017 |
| Safetech Safety System Limited | Professional & scientific | 2000 |
| Safetybe Scaffolding NE Ltd | Construction | 2022 |
| Saffron Food Takeaway Limited | Hospitality | 2018 |
| Saffron Hill Food Ltd | Hospitality | 2022 |
| Saffron Street Kitchen Ltd | Hospitality | 2026 |
| Saffrons Beauty Ltd | Other services | 2024 |
| Sagar Seaham Limited | Hospitality | 2011 |
| Sagman Limited | Information & communication | 2009 |
| SAI Hanuman Ltd | Wholesale & retail | 2024 |
| SAI Varahi Limited | Administrative & support | 2021 |
| Saints & Sinners Sunderland Ltd | Hospitality | 2019 |
| Saints Visuals Ltd. | Information & communication | 2025 |
| Sajva Services Limited | Information & communication | 2008 |
| Sakib'Sstore Ltd | Wholesale & retail | 2022 |
| Sakris Properties Ltd | Real estate | 2025 |
| Sale Sync Ltd | Information & communication | 2014 |
| Sales & Procurement (International) Limited | Information & communication | 1987 |
| Saltburn Leisure Limited | Arts & recreation | 2012 |
| SAM Consult Limited | Professional & scientific | 2019 |
| SAM Hakim Civil Engineering Ltd | Construction | 2014 |
| Saman 1318 Ltd | Hospitality | 2024 |
| Sambuca Sunderland Limited | Hospitality | 2014 |
| Samda Africano Limited | Wholesale & retail | 2025 |
| Sami MO Ltd | Hospitality | 2026 |
| Samjed World Ltd. | Real estate | 2024 |
| Sams Kebab & Pizzeria Ltd | Hospitality | 2025 |
| Samuel JR Temporal Ltd | Health & social care | 2021 |
| Samuel Leisure Ltd | Hospitality | 2014 |
| SAMYAR1396 Ltd | Other services | 2022 |
| Sana Cafe Limited | Hospitality | 2025 |
| Sana Soul Ltd | Hospitality | 2025 |
| Sand Dancer Marketing Ltd | Information & communication | 2022 |
| Sanddancer Barbers Ltd | Other services | 2024 |
| Sanddancer Property Ltd | Real estate | 2025 |
| Sandhill Little Angels Nursery Limited | Education | 2002 |
| Sandhu HS Ltd | Wholesale & retail | 2025 |
| Sandswindowcleaning Ltd | Administrative & support | 2025 |
| Sandy COD FRY Limited | Hospitality | 2019 |
| Sangha Trading Limited | Wholesale & retail | 2008 |
| Sanghat Ltd | Wholesale & retail | 2025 |
| Sankimmeg Limited | Health & social care | 2023 |
| Santaff Consultancy Ltd | Professional & scientific | 2023 |
| Santana Food Limited | Wholesale & retail | 2020 |
| Santinos Food & Wine Ltd | Hospitality | 2018 |
| Saphiraé Jewellery Ltd | Wholesale & retail | 2025 |
| Sapphire Digbeth Ltd | Real estate | 2025 |
| SAR Brothers Limited | Hospitality | 2020 |
| Sara's Pizza House Ltd | Hospitality | 2023 |
| Sarab Ltd | Extraterritorial | 2020 |
| Saraf Bakery Cafe Ltd | Hospitality | 2019 |
| Sarah Jane Mccusker Limited | Health & social care | 2024 |
| Sarah Mckenna HR Recruitment Limited | Administrative & support | 2016 |
| Sarcasms Association Limited | Arts & recreation | 1995 |
| Sardol Ltd | Other services | 2026 |
| Sarela Properties Ltd | Real estate | 2018 |
| Sarf (NE) Limited | Households | 2006 |
| Sarosakbos General Goods and Export Limited | Wholesale & retail | 2025 |
| Sarra Web Ltd | Information & communication | 2022 |
| SAS Elite Installations Ltd | Construction | 2023 |
| Sass Consulting Limited | Professional & scientific | 2010 |
| Satkayz Ltd | Transport & logistics | 2024 |
| Satnam Dulay Ltd | Real estate | 2024 |
| Satty Sells UK Ltd | Wholesale & retail | 2021 |
| Sauce N Grill Ltd | Hospitality | 2015 |
| Save and Drive Ltd | Wholesale & retail | 2019 |
| Savo Ltd | Hospitality | 2025 |
| Savour Africa Hub Ltd | Extraterritorial | 2025 |
| Saxons (Photomarket & Hi-Fi) Limited | Real estate | 1924 |
| SAY Consultancy Limited | Professional & scientific | 2008 |
| SB Barbering Academy Limited | Education | 2014 |
| SB Facilities Limited | Construction | 2018 |
| SB Ironmongery Solutions Limited | Manufacturing | 2013 |
| Sb-Ftm Ltd | Construction | 2026 |
| SBS Estates (NE) Limited | Real estate | 2025 |
| SC Electrical (NE) Ltd | Construction | 2017 |
| SC Preservation Limited | Construction | 2025 |
| SCA Self Storage Doncaster Ltd | Real estate | 2025 |
| SCA Self Storage Limited | Transport & logistics | 2020 |
| SCA Self Storage Real Estate Ltd | Real estate | 2022 |
| SCA Self Storage Rotherham Ltd | Real estate | 2024 |
| Scarramouche Creations Limited | Arts & recreation | 2023 |
| Scenic Roots Studio Ltd | Wholesale & retail | 2026 |
| Scfs (Contracts) Limited | Administrative & support | 2001 |
| Schengex Tours & Travels Ltd | Administrative & support | 2024 |