| Ferguson Plant & Machinery Limited | Administrative & support | 2020 |
| Fernando & Sons Property Limited | Wholesale & retail | 2024 |
| Fernando Wholesale Ltd | Wholesale & retail | 2025 |
| Fernville Scott Limited | Other services | 2003 |
| Ferry Farm Kennels Ltd | Hospitality | 2012 |
| Fibre Hoist North East Ltd | Construction | 2024 |
| Fibreconnex Ltd | Construction | 2022 |
| Field Blade Services Ltd | Manufacturing | 2023 |
| Fifthstrain Ltd | Wholesale & retail | 2022 |
| Figex Corporation Ltd | Construction | 2025 |
| Fight Connect Ltd | Information & communication | 2023 |
| Fili DEI Ltd | Information & communication | 2024 |
| Finance ACT Limited | Financial services | 2025 |
| Finance My Will Ltd | Financial services | 2025 |
| Finavant Ltd | Information & communication | 2024 |
| Finesse Landscapes Ltd | Administrative & support | 2025 |
| Finger of Fate Limited | Real estate | 2018 |
| Finlay Court Management Company Limited | Real estate | 2015 |
| Finley Doodle Limited | Real estate | 2024 |
| Fire & Safety Services NE Ltd | Public administration | 2020 |
| Fire Lining Services Limited | Administrative & support | 2010 |
| Fire Lining Systems Limited | Administrative & support | 2006 |
| Firehorse Entertainment Ltd | Arts & recreation | 2026 |
| Firekat Limited | Information & communication | 2009 |
| Firgreen Energyfarm Limited | Energy | 2024 |
| First AID, Safety and Security Training Ltd | Education | 2025 |
| First Bars Group Limited | Hospitality | 2019 |
| First Choice G.O.C Ltd | Professional & scientific | 2022 |
| First Choice Renewables Ltd | Energy | 2019 |
| First Class Traditional Barber Ltd | Other services | 2019 |
| First Cohort Incorporated Ltd | Administrative & support | 2024 |
| First Control Academy Community Interest Company | Education | 2024 |
| First Leap Ltd | Real estate | 2025 |
| First Modern Properties Ltd | Real estate | 2014 |
| First Point Trading Ltd | Wholesale & retail | 2023 |
| Fiscus North Limited | Financial services | 2005 |
| Fish and Chips Sunderland Ltd | Hospitality | 2025 |
| FISH4U Ltd | Hospitality | 2025 |
| Fit JAM Limited | Arts & recreation | 2016 |
| Fitins Ltd | Information & communication | 2024 |
| Fitz Architects Limited | Professional & scientific | 2007 |
| Fitzpatrick Property Investments Ltd | Real estate | 2023 |
| Five Star Northumbria Ltd | Transport & logistics | 2024 |
| FJ Reino Limited | Wholesale & retail | 2023 |
| FL Electrical Services Ltd | Construction | 2020 |
| Flair Blinds Limited | Manufacturing | 2000 |
| Flamingo IB Limited | Financial services | 2026 |
| Flawless Exteriors NE Limited | Administrative & support | 2024 |
| Fleet Solutions North East Ltd | Transport & logistics | 2026 |
| FLEETM8 Limited | Wholesale & retail | 2008 |
| Fleetwood Lettings Ltd | Real estate | 2020 |
| Flex Group NE Holdings Ltd | Financial services | 2023 |
| Flex Group NE Limited | Real estate | 2021 |
| Flex Interiors Ltd | Other services | 2016 |
| Flex Joinery Ltd | Manufacturing | 2018 |
| Flints Collectibles Ltd | Wholesale & retail | 2024 |
| Floor Trader Direct Ltd | Wholesale & retail | 2014 |
| Flooring Komplete Limited | Construction | 2026 |
| Floortex Flooring Ltd | Manufacturing | 2022 |
| Flour Secrets Limited | Manufacturing | 2025 |
| Flourish Afro Caribbean Shop Ltd | Wholesale & retail | 2025 |
| Flowtec NE Limited | Construction | 2024 |
| Flowwithgee Ltd | Other services | 2026 |
| Flutters and Strutters | Information & communication | 2022 |
| FM MEN Limited | Other services | 2019 |
| FM Styling Ltd | Other services | 2023 |
| FMD Homes Ltd | Real estate | 2026 |
| FNA Digital Ltd | Information & communication | 2016 |
| Focal Point Photography Limited | Information & communication | 2011 |
| Focus (Sunderland) CIC | Hospitality | 2024 |
| Focus Homes North East Limited | Real estate | 2019 |
| Fogity Group Ltd | Real estate | 2026 |
| Folgads Consulting Limited | Professional & scientific | 2014 |
| Fona P Ltd | Hospitality | 2019 |
| Fona Pizza Ltd | Wholesale & retail | 2024 |
| Fone Xperts Sunderland Ltd | Wholesale & retail | 2021 |
| Food 38 Ltd | Hospitality | 2025 |
| Food NV Ltd | Hospitality | 2019 |
| Foodie Food House Ltd | Hospitality | 2018 |
| Foodimus Limited | Wholesale & retail | 2024 |
| Football FUN Factory (Community 055) Limited | Arts & recreation | 2022 |
| Force Recruitment Ltd. | Professional & scientific | 1995 |
| Foresight Elearning and Creative Limited | Information & communication | 2016 |
| Forevercare Manchester Limited | Health & social care | 2023 |
| Forevery Limited | Wholesale & retail | 2025 |
| Forge Innovation and Ventures Ltd | Information & communication | 2026 |
| Forgotten Bargains Limited | Wholesale & retail | 2018 |
| Forhan Indian Food Ltd | Hospitality | 2017 |
| Forlah Multi Service Ltd | Transport & logistics | 2025 |
| Formex Group Ltd | Construction | 2021 |
| Forrest Financial Ltd | Professional & scientific | 2012 |
| Forresters Arms (Sunderland) Limited | Hospitality | 2013 |
| Forster Information Technology Ltd | Information & communication | 2025 |
| Forster's Estates Ltd | Real estate | 2024 |
| Forthcoming Group Ltd | Construction | 2022 |
| Fortress Close Protection & Risk Management Ltd | Administrative & support | 2026 |
| Fortunaee Ltd | Information & communication | 2019 |
| Forty One Thirty Holdings Ltd | Real estate | 2023 |
| Forty One Thirty NE Ltd | Manufacturing | 2022 |
| Forza Property Group Limited | Real estate | 2024 |