| EV Car Charge UK Ltd | Construction | 2021 |
| Evalsamjay Limited | Construction | 2020 |
| Even Arena Ltd | Information & communication | 2020 |
| Eventitys Signature Ltd | Professional & scientific | 2025 |
| Everbright Dental Ltd | Health & social care | 2025 |
| Everest Roofing and Building NE Ltd | Construction | 2026 |
| Everett Administration Ltd | Financial services | 2017 |
| Evergreen Electric Vehicles Limited | Construction | 2022 |
| Everlash Ltd | Other services | 2025 |
| Everlasting Memorials Sunderland Limited | Other services | 2025 |
| Evermill Healthcare Limited | Health & social care | 2026 |
| Everscore Limited | Professional & scientific | 2021 |
| Evesther Architectural Steelwork Limited | Construction | 2018 |
| Evie & Leiarna Ltd | Hospitality | 2022 |
| Evoke Connectivity Services Ltd | Construction | 2025 |
| Evoke Heat Ltd | Professional & scientific | 2012 |
| Evolve and Heal Therapy Ltd | Health & social care | 2025 |
| Exariis Limited | Professional & scientific | 2007 |
| Excalibur & Keswick Groundworks Limited | Manufacturing | 2010 |
| Excel Groundworks Ltd | Construction | 2024 |
| Excel Tiling KH Limited | Construction | 2026 |
| Excellence Community Care Ltd | Real estate | 2023 |
| Excelsior Services (Holdings) Limited | Professional & scientific | 2011 |
| Excelsior Services (Residential) Limited | Construction | 2014 |
| Excelsior Services (Student Accommodation) Limited | Construction | 2014 |
| Exclussive Cargo Ltd | Transport & logistics | 2025 |
| Executive Car & Commercial Valeting Services Limited | Other services | 2001 |
| Executive Stays North East Ltd | Real estate | 2026 |
| Exile JJA Ltd | Arts & recreation | 2023 |
| Express Brands Ltd | Wholesale & retail | 2009 |
| Express Hand Carwash (Elswick) Ltd | Other services | 2019 |
| Express Managed Services (NE) Limited | Construction | 2026 |
| Express Managed Services Limited | Information & communication | 2017 |
| Expressthat Ltd | Information & communication | 2023 |
| Exquisite Prime Ltd | Wholesale & retail | 2025 |
| Ezerr Services Ltd | Administrative & support | 2026 |
| Ezra's Garden Ltd | Administrative & support | 2021 |
| F & L Holdings Ltd | Real estate | 2017 |
| F I Maguire Limited | Wholesale & retail | 1959 |
| F R Property Services Ltd | Real estate | 2026 |
| F&F Flooring Solutions Ltd | Construction | 2022 |
| F. Lowes Plumbing & Heating Ltd | Water & waste | 2003 |
| Fabio's Bistro Limited | Hospitality | 2024 |
| Fabric Skateboards Limited | Wholesale & retail | 2010 |
| FAC Window Cleaning Services Ltd | Administrative & support | 2024 |
| Face Forward NE Ltd | Real estate | 2018 |
| Face-Markets Ltd. | Extraterritorial | 2013 |
| Fairstone Capital Investment Limited | Other services | 2015 |
| Fairstone Corporate Management Limited | Financial services | 2025 |
| Fairstone Executive Management Limited | Other services | 2016 |
| Fairstone Financial Management Limited | Financial services | 2005 |
| Fairstone Group Limited | Financial services | 2008 |
| Fairstone Holdings (Ireland) Ltd | Administrative & support | 2022 |
| Fairstone Holdings Limited | Administrative & support | 2008 |
| Fairstone Private Wealth Limited | Financial services | 2006 |
| Fairstone Wealth Management Limited | Administrative & support | 1998 |
| Fairways Funeral Directors Limited | Other services | 2024 |
| Faith Luxury Hair Limited | Wholesale & retail | 2026 |
| Falcon Computers Limited | Wholesale & retail | 2004 |
| Falkenberg Solutions Ltd | Health & social care | 2016 |
| Fall Protection UK Limited | Construction | 2003 |
| Faltec Europe Limited | Manufacturing | 1989 |
| Fangbian Ltd | Households | 2026 |
| Fans Museum CIC | Arts & recreation | 2016 |
| Fantastic H&H Nails Limited | Other services | 2019 |
| Farage Service Limited | Health & social care | 2014 |
| Farah's Sunderland Limited | Hospitality | 2020 |
| Farooqi Hub Ltd | Wholesale & retail | 2025 |
| Farrells Properties Limited | Real estate | 2021 |
| Farvahar NE Ltd | Hospitality | 2025 |
| Fast Channel UK Limited | Wholesale & retail | 2004 |
| Fast Line Solutions Limited | Professional & scientific | 2013 |
| Fastclad (NE) Limited | Construction | 2026 |
| Fastfix Building Maintenance Ltd | Construction | 2011 |
| Fastparcel Ltd | Transport & logistics | 2026 |
| FAT Angus Ltd | Hospitality | 2025 |
| FAT BOY Station Ltd | Hospitality | 2019 |
| Fathom Consultancy Solutions Limited | Professional & scientific | 2017 |
| Fatmouth Limited | Hospitality | 2022 |
| Fatu Brand Ltd | Transport & logistics | 2026 |
| Fausto Coppa Limited | Hospitality | 2019 |
| Fausto Group Ltd | Hospitality | 2023 |
| Fausto Hub C.I.C. | Other services | 2024 |
| Faze Electrical Services Ltd | Other services | 2018 |
| FBS North East Ltd | Construction | 2018 |
| FC Roast Limited | Wholesale & retail | 2020 |
| FCOMPANYPROP1 Ltd | Real estate | 2025 |
| Fcstam Limited | Wholesale & retail | 2023 |
| Feast and Beyond Ltd | Hospitality | 2025 |
| FED Takeaway Ltd | Hospitality | 2020 |
| Fedash Consultancy Limited | Professional & scientific | 2017 |
| Fedash Real Estates Limited | Construction | 2022 |
| Fedol Ziquorah Services Limited | Administrative & support | 2025 |
| Feeling Fabulous Productions Ltd | Information & communication | 2008 |
| Felstead Developments Limited | Construction | 2019 |
| Fencer Player Ltd | Real estate | 2023 |
| Fencing Direct (UK) Limited | Extraterritorial | 2000 |
| Fenix Property Sales & Lettings Ltd | Real estate | 2014 |
| Fenwick Holdings Limited | Administrative & support | 2025 |
| Fere & Hasti Ltd | Other services | 2018 |