| Elite Electrical Solutions NE Ltd | Construction | 2019 |
| Elite Fitness SR1 Ltd | Arts & recreation | 2024 |
| Elite Health and Wellness CIC | Health & social care | 2022 |
| Elite Rendering & Plastering Ltd | Construction | 2021 |
| Elite Security Shutters Ltd | Construction | 2025 |
| Elite Van Solutions Ltd | Manufacturing | 2025 |
| Elitemica Ltd | Wholesale & retail | 2025 |
| Eliten Designs Limited | Information & communication | 2025 |
| Elixir Automotive Ltd | Wholesale & retail | 2026 |
| Ellavan Cakes&Treats Ltd | Hospitality | 2025 |
| Ellesmere Linen Hire Limited | Hospitality | 2003 |
| Ellie Property Developments Limited | Real estate | 2022 |
| Ellimol Consultancy Limited | Professional & scientific | 2025 |
| Ellis James Limited | Wholesale & retail | 2018 |
| Ellmarsh Consultancy Ltd | Professional & scientific | 2023 |
| Elmo Media Ltd | Professional & scientific | 2023 |
| Elms 7 Co Limited | Households | 2023 |
| Elms Method Ltd | Professional & scientific | 2025 |
| ELR Renewable’S Ltd | Construction | 2025 |
| Elris Konsult Ltd | Hospitality | 2025 |
| Elvaris Limited | Financial services | 2025 |
| EM8 Technology Ltd | Professional & scientific | 2008 |
| Ember & Stone Kitchen Limited | Hospitality | 2026 |
| Ember Impact Solutions Ltd | Information & communication | 2023 |
| Ember Restaurants Ltd | Hospitality | 2023 |
| Emergency First Response Ltd | Health & social care | 2020 |
| Emily Charles Limited | Real estate | 2014 |
| Emily's Nurseries Limited | Wholesale & retail | 2003 |
| Emios Limited | Professional & scientific | 2026 |
| Emjayem Interiors Limited | Construction | 2021 |
| EML Solutions Ltd | Construction | 2025 |
| Emma Kassim Management Consultancy Ltd | Professional & scientific | 2025 |
| Emma Newham Fitness Limited | Education | 2025 |
| Emmanek Resources Ltd | Professional & scientific | 2022 |
| Emmavincent.Com Ltd | Health & social care | 2020 |
| Emmersons Solicitors Ltd | Professional & scientific | 2014 |
| Empire 73 Limited | Real estate | 2024 |
| Empire Homes and Property Surveying Limited | Construction | 2017 |
| Empire Investment Properties Limited | Real estate | 2013 |
| Empire Nationwide Ltd | Wholesale & retail | 2017 |
| Employment Solutions North East Ltd | Information & communication | 2019 |
| Empyrea Consulting Ltd | Professional & scientific | 2022 |
| Emrad Medical Imaging Limited | Health & social care | 2025 |
| Emre's Kitchen Limited | Hospitality | 2025 |
| EMS Building Solutions Ltd | Construction | 2023 |
| EMS Metering Ltd | Energy | 2021 |
| EMS Training North East Limited | Education | 2022 |
| Enable Healthcare Ltd | Health & social care | 2013 |
| Enautilus Ltd | Professional & scientific | 2025 |
| Enchanted Aesthetics Ltd | Health & social care | 2021 |
| Endtec Limited | Professional & scientific | 2019 |
| Energy Action Team Limited | Administrative & support | 2018 |
| Energy Base UK Ltd | Professional & scientific | 2023 |
| Energy Saving Consultants Ltd | Professional & scientific | 2024 |
| Enerjoy Limited | Extraterritorial | 2023 |
| Engineering Boulevard Ltd | Professional & scientific | 2024 |
| Engineering Trading Company Limited | Professional & scientific | 2020 |
| Engineering Xperts Holding Ltd | Professional & scientific | 2020 |
| English Rose Bridal Boutique Limited | Wholesale & retail | 2021 |
| Enhance Beauty Clinic NE Ltd | Other services | 2026 |
| Enhancedflooring Ltd | Construction | 2021 |
| Ennovit Technologies Ltd | Information & communication | 2025 |
| Ennywest World Limited | Wholesale & retail | 2025 |
| Enrep Limited | Wholesale & retail | 2022 |
| Enrolex Limited | Financial services | 2014 |
| Enroute X Limited | Information & communication | 2022 |
| Enviro Seal Ltd | Construction | 2020 |
| Enviroknight Services Ltd | Water & waste | 2018 |
| Envision Electrical Services Ltd | Construction | 2021 |
| Eomac UK Investments Limited | Financial services | 2022 |
| EPG Property Management Ltd | Real estate | 2010 |
| Epic Sunderland Vape Ltd | Wholesale & retail | 2022 |
| Epic Vape Store Ltd | Wholesale & retail | 2020 |
| Epicentre CIC | Wholesale & retail | 2023 |
| Epos Touch Limited | Information & communication | 2018 |
| Epsilon Basics Limited | Wholesale & retail | 2024 |
| Equestrian Rose Trading Ltd | Wholesale & retail | 2026 |
| Equi-Med AG Limited | Manufacturing | 2011 |
| Ergen Roma Ltd | Hospitality | 2019 |
| Erika Delivery's Limited | Other services | 2021 |
| ERP Inspection Limited | Professional & scientific | 2025 |
| ERT & ERS Ltd | Hospitality | 2025 |
| Escalon Limited | Real estate | 2020 |
| Escape Sports Limited | Professional & scientific | 2020 |
| Escobars (Newcastle) Ltd | Hospitality | 2012 |
| Esessee Limited | Administrative & support | 2024 |
| Espa Research Limited | Professional & scientific | 2009 |
| ESR Financial Management LLP | | 2012 |
| ESS Holdings (Edinburgh) Limited | Administrative & support | 2010 |
| Essential Electrical North East Limited | Construction | 2021 |
| Estandz Place Consulting Ltd | Professional & scientific | 2025 |
| ETH Strategic Consulting Limited | Professional & scientific | 2023 |
| Ethanbuild Ltd | Construction | 2025 |
| Etpbrothers Ltd | Real estate | 2025 |
| ETY North East Limited | Hospitality | 2019 |
| Eunibenz Concept Ltd | Other services | 2017 |
| Euro GPS Limited | Health & social care | 2005 |
| European Express Mini Market Ltd | Wholesale & retail | 2024 |
| European Store Sunderland Ltd | Wholesale & retail | 2025 |
| Eutravel Ltd | Administrative & support | 2015 |