| Eaglelite Limited | Information & communication | 2025 |
| Eaja Offshore Ltd | Construction | 2024 |
| EAR WAX Clinic Sunderland Ltd | Health & social care | 2026 |
| Earth Changers Limited | Administrative & support | 2018 |
| Easington Pizza Ltd | Hospitality | 2025 |
| East Coast Inc. Limited | Hospitality | 2017 |
| East Durham IT Limited | Information & communication | 2012 |
| East Durham Maintenance Limited | Administrative & support | 2017 |
| East Durham Signs Limited | Professional & scientific | 2006 |
| East END Timber Ltd | Manufacturing | 2023 |
| Eastendbodyshop Limited | Wholesale & retail | 2011 |
| Eastfield Lettings Limited | Real estate | 2025 |
| EASTSTREET19 Ltd | Hospitality | 2022 |
| Easy Chew Ltd | Professional & scientific | 2022 |
| Easy Sale Ltd | Wholesale & retail | 2025 |
| Easymove Lettings Ltd | Real estate | 2013 |
| Ebonwell Limited | Wholesale & retail | 2000 |
| EBR Flexoprinters Limited | Professional & scientific | 1978 |
| ECM Construction Ltd | Construction | 2022 |
| Eco Edge Installations Ltd | Wholesale & retail | 2025 |
| Eco Edge Marketing Limited | Professional & scientific | 2025 |
| Eco Gold Limited | Construction | 2025 |
| Eco Molly Ltd | Wholesale & retail | 2025 |
| Eco Sleep Beds Ltd | Wholesale & retail | 2024 |
| Eco Sleep Cramlington Ltd | Wholesale & retail | 2024 |
| Eco Sleep Durham Clearance Ltd | Wholesale & retail | 2024 |
| Eco Sleep Durham Manufacturing Ltd | Wholesale & retail | 2024 |
| Eco Sleep Gateshead Ltd | Wholesale & retail | 2025 |
| Eco Sleep North East Ltd | Wholesale & retail | 2024 |
| Eco Sleep Shields Ltd | Wholesale & retail | 2025 |
| Eco Sleep South Shields Ltd | Wholesale & retail | 2024 |
| Eco Sleep Washington Ltd | Wholesale & retail | 2024 |
| Eco Wise NE Ltd | Construction | 2024 |
| Ecofocus Property Services Ltd | Construction | 2025 |
| Ecofuture Technology Limited | Construction | 2021 |
| Ecokeen Ltd | Professional & scientific | 2026 |
| Ecolight Ltd | Wholesale & retail | 2026 |
| Ecomonkeyne Ltd | Construction | 2022 |
| Ecosolutions Network Ltd | Professional & scientific | 2022 |
| Ecospark Cleaners Ltd | Administrative & support | 2024 |
| Ecosphere AI Solutions Ltd | Wholesale & retail | 2025 |
| Ecostar Renewables Ltd | Construction | 2025 |
| Ecosy Energy Ltd | Construction | 2017 |
| Ecosy Energy Solutions Ltd | Professional & scientific | 2024 |
| ECR Engineering Ltd | Construction | 2026 |
| ECS Works Limited | Mining & quarrying | 2018 |
| Eden Community Hub CIC | Hospitality | 2024 |
| Eden Management Roker Limited | Real estate | 2011 |
| Eden Wellness Events Limited | Administrative & support | 2025 |
| EDF EN UK Limited | Financial services | 1998 |
| EDF Haulage Limited | Transport & logistics | 2019 |
| EDF Renewables Solar Limited | Energy | 2019 |
| Edgerise Consultancy Ltd | Professional & scientific | 2023 |
| Edible INK Printers Ltd | Manufacturing | 2024 |
| Edmundson Building & Preservation Limited | Construction | 2002 |
| Edmundson Holdings Limited | Financial services | 2022 |
| Edo-Delta Community Sunderland CIC | Other services | 2023 |
| Edres Pizza Ltd | Hospitality | 2025 |
| Edsoncar Limited | Other services | 2023 |
| EDUC8 Sport Limited | Education | 2024 |
| Education 4.0 Limited | Education | 2020 |
| Education and Services for People With Autism Limited | Education | 1994 |
| Education Buddies Ltd | Education | 2024 |
| Education, Learning & Improvement Services Ltd | Education | 2018 |
| Edward Chaston Limited | Wholesale & retail | 1960 |
| Edwards Plumbing Heating & Electrical Ltd | Construction | 2021 |
| EE Wholesale (UK) Limited | Manufacturing | 2017 |
| EEC Solutions Global Limited | Energy | 2017 |
| EEC Solutions Limited | Energy | 2016 |
| Eedor Limited | Health & social care | 2025 |
| Eejab Company Limited | Wholesale & retail | 2023 |
| EEU Ltd | Professional & scientific | 2024 |
| Eeve Developments & Services Ltd | Construction | 2019 |
| Efam Properties Limited | Real estate | 2023 |
| Efficient Group Holdings Limited | Financial services | 2023 |
| Efficient Investments Limited | Real estate | 2023 |
| EGC Homes and Properties Limited | Real estate | 2025 |
| EGH Subsea Ltd | Professional & scientific | 2026 |
| Egoink Limited | Other services | 2010 |
| EHC Sport Ltd | Manufacturing | 2021 |
| Ehc-Properties UK Limited | Construction | 2018 |
| Ehiame Limited | Information & communication | 2026 |
| Ehln Services Limited | Construction | 2018 |
| Eight Estates Limited | Households | 2010 |
| Eight SQ Project Services Limited | Construction | 2025 |
| EJ Global Service Limited | Real estate | 2025 |
| EJT Pizza Ltd | Hospitality | 2020 |
| El-Roi African Stores Limited | Wholesale & retail | 2025 |
| Elderbrook Ltd | Construction | 2020 |
| Electrical Design Solutions (NE) Limited | Construction | 2013 |
| Electrical Solutions (NE) Ltd | Manufacturing | 2015 |
| Electro Mechanical Solutions T/A EMS FM Group Limited | Construction | 2013 |
| Electro Quality Services Ltd | Construction | 2026 |
| Element Installs Ltd | Construction | 2025 |
| Elene Villa Limited | Hospitality | 1984 |
| Elevate Skincare Ltd | Other services | 2024 |
| Elfaskin Limited | Other services | 2025 |
| Elgrato Ltd | Professional & scientific | 2023 |
| Elharty Ltd | Information & communication | 2025 |
| Elite Call UK Ltd | Administrative & support | 2025 |