| Foundation of Light | Education | 2001 |
| Fountain Bliss Limited | Real estate | 2024 |
| Four Gems Distribution Ltd | Wholesale & retail | 2025 |
| Four Lane Cars Ltd | Wholesale & retail | 2021 |
| Four Walls Lettings Ltd | Real estate | 2017 |
| Fowler Logistics Ltd | Transport & logistics | 2026 |
| Foxs Trading Limited | Wholesale & retail | 2023 |
| Foyle Street RTM Company Limited | Extraterritorial | 2023 |
| FP Energy Services Ltd | Professional & scientific | 2013 |
| FPC Consultancy Limited | Professional & scientific | 2024 |
| FPC INV 1 Limited | Financial services | 2024 |
| FPC INV 2 Limited | Financial services | 2025 |
| Fpga Design Solutions Limited | Information & communication | 2012 |
| Frallo NE Ltd | Hospitality | 2025 |
| Framesavers Limited | Professional & scientific | 2009 |
| Frances Marshall Limited | Other services | 2015 |
| Francis Masterman Limited | Arts & recreation | 2018 |
| Frank Smith & Co. (Sunderland) Limited | Wholesale & retail | 1959 |
| Franklin Store Ltd | Wholesale & retail | 2022 |
| Franks Portlock Consulting Limited | Water & waste | 2006 |
| Franseb Properties Ltd | Real estate | 2026 |
| Frapor Support Services Limited | Health & social care | 2022 |
| Frasers Auto Repairs Ltd | Administrative & support | 2017 |
| Frasers Storage and Lettings Ltd | Transport & logistics | 2024 |
| Fratelli Ryhope Ltd | Hospitality | 2019 |
| Fred Corner Limited | Construction | 2002 |
| Freedom 68 Ltd | Real estate | 2024 |
| Freedom Performance Coaching Ltd | Professional & scientific | 2025 |
| Freedom Physiotherapy North East Ltd | Health & social care | 2026 |
| Freers (U.K.) Ltd | Manufacturing | 2011 |
| French United Capital Ltd | Information & communication | 2019 |
| Freola Holdings Limited | Administrative & support | 2019 |
| Fresh Fade 1 Ltd | Other services | 2025 |
| Fresh Floors Carpet Cleaning Ltd | Administrative & support | 2026 |
| Fresh Foods Sunderland Ltd | Hospitality | 2026 |
| Freshview Services Ltd | Administrative & support | 2025 |
| Freshway Retail Ltd | Wholesale & retail | 2023 |
| Fretta by Ruhe Ltd | Hospitality | 2025 |
| Freya Group Limited | Financial services | 2022 |
| Freya's Kitchen Ltd | Hospitality | 2019 |
| Friday Buildings Limited | Real estate | 2024 |
| Friends of Sunderland Minster | Other services | 2003 |
| Froghopper Services Ltd | Professional & scientific | 2014 |
| Frontline Print Limited | Manufacturing | 2021 |
| FRY FRY (NE) Limited | Administrative & support | 2022 |
| FRY Inn (Hylton Road) Ltd | Hospitality | 2019 |
| FSH Consultancy Services Ltd | Professional & scientific | 2018 |
| FTD (NE) Ltd | Wholesale & retail | 2022 |
| FTM58 Ltd | Manufacturing | 2013 |
| FTW 1984 Ltd | Real estate | 2021 |
| FU1980 Limited | Wholesale & retail | 2019 |
| Fuego Property Ltd | Real estate | 2022 |
| Fulford Consultants Ltd | Administrative & support | 2025 |
| Full Moon Group Ltd | Manufacturing | 2021 |
| Full OUT Legal Ltd | Professional & scientific | 2026 |
| Fulling Ltd | Hospitality | 2014 |
| Fulwell Castings Talent Limited | Information & communication | 2025 |
| Fulwell Ceiling Contracts Ltd | Construction | 1988 |
| Fulwell Chiropractic Limited | Health & social care | 2015 |
| Fulwell Community Library Community Interest Company | Arts & recreation | 2017 |
| Fulwell Consulting PMC Limited | Other services | 2015 |
| Fulwell Design and Draughting Ltd | Professional & scientific | 2007 |
| Fulwell Property Developments Ltd | Real estate | 2025 |
| Fulwell Property Services Limited | Construction | 2025 |
| Fulwell Tandoori Chef Ltd | Hospitality | 2024 |
| Fundraise and Recycle Limited | Wholesale & retail | 2021 |
| Furniture & Interiors NE Ltd | Wholesale & retail | 2020 |
| Furniture Collection Ltd | Wholesale & retail | 2024 |
| Furniture Express Sunderland Ltd | Wholesale & retail | 2019 |
| Furniture Home Stores Galleries Ltd | Wholesale & retail | 2021 |
| Furniture Home Stores Online Ltd | Wholesale & retail | 2019 |
| Furniture Warehouse N.E Ltd | Wholesale & retail | 2020 |
| Fuse Luxury Ltd | Wholesale & retail | 2024 |
| Fusion OIL International Limited | Wholesale & retail | 2025 |
| Future Infrastructure Ltd | Construction | 2025 |
| Future Proof Energy Assessments Ltd | Professional & scientific | 2025 |
| FW Medical Aesthetic Services Limited | Health & social care | 2025 |
| FWR Coatings (NE) Ltd | Construction | 2013 |
| G & C Property & Letting Ltd | Real estate | 2025 |
| G & G Smith Limited | Construction | 2020 |
| G & T Aluminium Limited | Construction | 2017 |
| G Castle Ltd | Hospitality | 2023 |
| G Hughes (North East) Limited | Wholesale & retail | 2012 |
| G Sloanes Financial Services Ltd | Professional & scientific | 2016 |
| G Taylor Plumbing and Heating Engineers Ltd | Construction | 2013 |
| G Z Extensions Ltd | Construction | 2025 |
| G&C Solution Ltd | Administrative & support | 2025 |
| G&T Global Limited | Transport & logistics | 2025 |
| G&T Retail Ltd | Wholesale & retail | 2026 |
| G. Dobson Accountancy Services Limited | Professional & scientific | 1996 |
| G. Dodd Enterprises Ltd | Education | 2019 |
| G. O'Brien & Sons (Nationwide Demolition Contractors) Limited | Water & waste | 1995 |
| G. R. P. Building and Maintenance Limited | Construction | 1997 |
| G.M. Leisure Limited | Arts & recreation | 1997 |
| G.W. Herdman (Chemists) Limited | Health & social care | 1995 |
| GA Media Ltd | Information & communication | 2017 |
| Gabbyfranks Services Ltd | Health & social care | 2016 |
| Gabrieles (Sunderland) Limited | Hospitality | 2002 |
| Galileo ITS Ltd | Administrative & support | 2006 |
| Gallaghers North East Ltd | Wholesale & retail | 2026 |