| Courseapp Limited | Information & communication | 2018 |
| Courts Flooring Ltd | Construction | 2019 |
| COW Systems Ltd | Information & communication | 2013 |
| Cowcombe Ventures Limited | Real estate | 2004 |
| Cowen (Holdings) Limited | Financial services | 2016 |
| Coxwell Baptist Properties Ltd | Real estate | 2020 |
| Coxycox Limited | Professional & scientific | 2019 |
| CPP Rowley Limited | Financial services | 2002 |
| CQS Services Limited | Construction | 2016 |
| Craigton House 96 Bath Road Stroud Management Company Limited | Real estate | 2002 |
| Creating Business Growth (CBG) Ltd. | Information & communication | 2002 |
| Creative Curls Ltd | Information & communication | 2025 |
| Creative Horticulture Ltd | Agriculture & fishing | 2024 |
| Creative Self Consulting Ltd | Professional & scientific | 2024 |
| Creative Sustainability CIC | Education | 2010 |
| Creative Thread CIC | Education | 2023 |
| Crescent Care Home Cornwall Limited | Health & social care | 2018 |
| Crescita Consulting Ltd | Professional & scientific | 2014 |
| Crest Kitchens and Joinery Ltd. | Construction | 2014 |
| Crew Circle Ltd | Information & communication | 2026 |
| Crindau Management Company Limited | Real estate | 2020 |
| Cristie Software Acquisitions Limited | Financial services | 2022 |
| Cristie Software Limited | Information & communication | 2007 |
| Cristie Technologies Limited | Information & communication | 2021 |
| Crossfields Institute | Education | 2008 |
| Crspv Ltd | Real estate | 2017 |
| Crust Issues Ltd | Hospitality | 2018 |
| Crystal Clean Company Stroud Ltd | Administrative & support | 2017 |
| Crystal Sound Sanctum Ltd | Wholesale & retail | 2024 |
| CSA Stroud Ltd | Real estate | 2021 |
| CSE Property Ltd | Real estate | 2014 |
| Cssc Trading Limited | Hospitality | 2024 |
| CTS (UK) Limited | Extraterritorial | 1996 |
| Cube Medical Consulting Limited | Professional & scientific | 2011 |
| Cube Medical Limited | Professional & scientific | 2011 |
| CUP of Tea Publishing Limited | Extraterritorial | 2023 |
| Cupola Productions Ltd | Information & communication | 2011 |
| Curious Caterpillars Ltd | Health & social care | 2014 |
| Curriculum Ltd | Information & communication | 2019 |
| Curry House Retail Ltd | Wholesale & retail | 2020 |
| Cuttin'Um Palace Ltd | Other services | 2009 |
| CVM Cyber Limited | Information & communication | 2020 |
| CWF Consultancy Limited | Real estate | 2002 |
| Cybercentrum Ltd | Information & communication | 2024 |
| Cypher Q Ltd | Administrative & support | 2021 |
| D & J Residential Ltd | Real estate | 2006 |
| D & X Associates Limited | Hospitality | 2011 |
| D J Melsome & SON Limited | Construction | 1997 |
| D M S New Build Limited | Construction | 2006 |
| D&B Audiotechnik GB Limited | Wholesale & retail | 2002 |
| D. Stainer-Hutchins Architects Limited | Professional & scientific | 2004 |
| D.A. Cook Heating Limited | Construction | 2002 |
| D.J. Melsome Limited | Real estate | 1976 |
| D2I Vantage Ltd | Information & communication | 2025 |
| Dafydd Ltd | Professional & scientific | 2014 |
| Dagenham Wind Park Limited | Energy | 1998 |
| Daikoku Ramen Cheltenham Ltd | Hospitality | 2025 |
| Daikoku Ramen Ltd | Hospitality | 2023 |
| Dairylight Limited | Wholesale & retail | 2011 |
| Daisy Finer Ltd | Professional & scientific | 2017 |
| Daisy Jane 2 Limited | Wholesale & retail | 2024 |
| Daisy Jane Limited | Wholesale & retail | 2014 |
| Dakaro Limited | Hospitality | 2019 |
| Dalby Wind Park Limited | Extraterritorial | 2008 |
| Dale Vince Limited | Professional & scientific | 2025 |
| Damsell Plastering Ltd | Construction | 2024 |
| Damson Website Design Limited | Information & communication | 2020 |
| DAN Cooper Motorsport Ltd | Wholesale & retail | 2022 |
| DAN Evans(Barry)Limited | Real estate | 1955 |
| Dani Biernat Limited | Information & communication | 2021 |
| Dark Light Developments Limited | Information & communication | 1998 |
| Darkgreener Ltd | Information & communication | 2010 |
| Darren Lewis Financial Planning Limited | Professional & scientific | 2020 |
| Darya Noor Limited | Extraterritorial | 2026 |
| Databugs Limited | Other services | 2012 |
| Datadecode Ltd | Professional & scientific | 2018 |
| Dattum Limited | Manufacturing | 2002 |
| David Hall Farriers Ltd | Agriculture & fishing | 2017 |
| Davies Landscape Architects Limited | Professional & scientific | 2006 |
| Davis & SON Electrical Ltd | Construction | 2025 |
| Davon's Heart Ltd | Hospitality | 2017 |
| Dbhf Limited | Wholesale & retail | 2014 |
| DCH Media Ltd | Manufacturing | 2025 |
| Ddaa Limited | Other services | 2017 |
| DE Havilland Fabrication & Welding Limited | Manufacturing | 1996 |
| DE Lacroix Hopf Ltd | Transport & logistics | 2026 |
| Dead Calm Consulting Ltd | Information & communication | 2021 |
| Deans Accounting & Admin Services Ltd | Professional & scientific | 2012 |
| Deans Court Cottages Limited | Hospitality | 2013 |
| Deans Court Gate House Limited | Hospitality | 2015 |
| Deans Court Weddings Limited | Hospitality | 2013 |
| Deck Services Limited | Transport & logistics | 2008 |
| Deckard Tannhaüser Limited | Financial services | 2025 |
| Decorvm Limited | Construction | 2022 |
| Demery Services Limited | Professional & scientific | 2013 |
| Democracy Club Community Interest Company | Other services | 2015 |
| Demonforge Cafe and Gaming Ltd | Wholesale & retail | 2025 |
| Denis Brown & SON (Nailsworth) Limited | Wholesale & retail | 1960 |
| Dennis S FRY Ltd | Professional & scientific | 2006 |
| Deomu Limited | Real estate | 2023 |