| Derivative Flow Limited | Information & communication | 2012 |
| Derwent Management Group Limited | Professional & scientific | 2020 |
| Derya Trading Ltd | Hospitality | 2023 |
| Design Decoded Ltd | Professional & scientific | 2019 |
| Design Soup Architecture Ltd | Professional & scientific | 2025 |
| Designbuilder Software Holdings Limited | Information & communication | 2022 |
| Designbuilder Software Limited | Information & communication | 2002 |
| Deuce Education Ltd | Education | 2022 |
| Devops Solutions Limited | Information & communication | 2014 |
| Devzilla Ltd | Information & communication | 2014 |
| DEX Audio Ltd | Manufacturing | 2023 |
| DFB EVS Ltd | Professional & scientific | 2023 |
| Dhanu Transport Limited | Transport & logistics | 2025 |
| Dialect Writers Community Interest Company | Arts & recreation | 2022 |
| Diamar Properties Ltd | Real estate | 2019 |
| Digital Pet Shop Limited | Wholesale & retail | 2025 |
| Digital Smile Laboratory Ltd | Manufacturing | 2023 |
| Digital Workshed Ltd | Information & communication | 2025 |
| Digitwell Solutions Ltd | Information & communication | 2014 |
| Diligent Accounting Services Limited | Professional & scientific | 2020 |
| Dine Wilder Limited | Hospitality | 2017 |
| Dinu Dinu Ltd | Hospitality | 2020 |
| Dinwoodie Motors Ltd | Wholesale & retail | 2021 |
| Diptribe Ltd | Wholesale & retail | 2023 |
| Disaster Care Cotswolds Limited | Administrative & support | 2018 |
| Dispensary Market Ltd | Health & social care | 2024 |
| Disruptive Otter Ltd | Professional & scientific | 2021 |
| Dissident Automotive Ltd | Professional & scientific | 2023 |
| Diverse Controls Ltd | Administrative & support | 2019 |
| Diverse Home Improvements Limited | Construction | 2019 |
| Dixon & Grey Kitchens Ltd | Wholesale & retail | 2019 |
| DIY Composites Ltd | Wholesale & retail | 2020 |
| DJD Carpentry and Building Ltd | Construction | 2022 |
| DJM Holdings Limited | Financial services | 2016 |
| DJR (Glos) Ltd | Administrative & support | 2009 |
| Dnha Limited | Professional & scientific | 2025 |
| DO Inc Ltd | Real estate | 2019 |
| Doddl Ltd | Manufacturing | 2013 |
| Dodeca Studio Limited | Information & communication | 2020 |
| Dodo Solutions Limited | Information & communication | 2020 |
| Domestic Science Home Ltd | Wholesale & retail | 2012 |
| Done for Ltd | Arts & recreation | 2011 |
| Doodle & Baggins LLP | | 2023 |
| Double EYE Productions Ltd | Information & communication | 2021 |
| Downs Mill Management Company Limited | Households | 1990 |
| DR Darren Walsh Ltd | Professional & scientific | 2023 |
| DR Mathewson Ltd | Health & social care | 2026 |
| Dream Gents CUT Ltd | Other services | 2025 |
| Dream Home Developments Limited | Construction | 2005 |
| Dremio Limited | Administrative & support | 2018 |
| Drew Landscaping Ltd | Administrative & support | 2023 |
| Drive UP Storage Stroud Ltd | Real estate | 2007 |
| Drlk Limited | Hospitality | 2024 |
| Drone Grid UK Ltd | Transport & logistics | 2026 |
| Drop in Pubs Ltd | Hospitality | 2014 |
| DS Stone Supplies Ltd | Wholesale & retail | 2013 |
| Dtsconnections Ltd | Education | 2026 |
| Duchy Court (Exmouth) Management Company Limited | Households | 2020 |
| Dudbridge Management Company Limited | Households | 1990 |
| Duke Associates Limited | Professional & scientific | 2017 |
| Dulater Hill Wind Park Limited | Extraterritorial | 2007 |
| Dundee Merchant Wind Park Limited | Energy | 2002 |
| Dust Breeding CIC | Education | 2025 |
| Dust Bunny Cleaning Services Limited | Administrative & support | 2023 |
| Dutyallow (PC) Limited | Professional & scientific | 1992 |
| Dynamic Payment Services Limited | Wholesale & retail | 2022 |
| Dysky Education Solutions Limited | Education | 2012 |
| E R Upholstery Ltd | Manufacturing | 2015 |
| E-Business Group Limited | Information & communication | 2000 |
| E. H. Capital Limited | Administrative & support | 2002 |
| E.S.S. Employment Limited | Administrative & support | 2003 |
| Eagle Mill Carpets Limited | Wholesale & retail | 2003 |
| Eagles Technical Services Ltd | Manufacturing | 2005 |
| EAP Research Consultancy Limited | Professional & scientific | 2022 |
| Earthstar Global Limited | Other services | 2025 |
| Easy Flow Finance Limited | Professional & scientific | 2025 |
| Easy Technical Services Ltd | Manufacturing | 2013 |
| Easy Window Cleaning Ltd | Administrative & support | 2023 |
| Ebley Development Limited | Real estate | 2012 |
| Ebley Estates Management Ltd | Households | 2022 |
| Ebworth Properties Limited | Real estate | 2018 |
| ECH Solutions Ltd | Manufacturing | 2008 |
| Eco Card Recycling Ltd | Water & waste | 2025 |
| Eco Cars Limited | Manufacturing | 2009 |
| Eco Engineering Limited | Construction | 2006 |
| Eco Haus Southwest Ltd | Construction | 2011 |
| Eco Labs Group Limited | Financial services | 2022 |
| Eco Labs NV 1 Limited | Financial services | 2022 |
| Eco Labs NV 2 Limited | Financial services | 2022 |
| Eco Park J13 Limited | Energy | 2018 |
| Ecobank Limited | Extraterritorial | 2004 |
| Ecocon Limited | Professional & scientific | 2009 |
| Ecoelectrical Limited | Professional & scientific | 2006 |
| Ecological Continuity Trust | Professional & scientific | 2008 |
| Ecotalk Limited | Information & communication | 2010 |
| Ecotech Wind Park Limited | Energy | 1998 |
| Ecotility Limited | Professional & scientific | 2009 |
| Ecotopia Limited | Wholesale & retail | 2004 |
| Ecotricity (Alveston Storage) Limited | Energy | 2018 |
| Ecotricity (Alveston) Limited | Energy | 2018 |