| Sentra Medical Ltd | Manufacturing | 2013 |
| Sentracare Stoke Limited | Health & social care | 2026 |
| SEP & March Ltd | Wholesale & retail | 2023 |
| SER Transport Ltd | Transport & logistics | 2021 |
| Seracena Limited | Information & communication | 2021 |
| Seraj UK Ltd | Wholesale & retail | 2024 |
| Sercado Ltd | Transport & logistics | 2017 |
| Serendib Foods Ltd | Hospitality | 2022 |
| Serendiparty Ltd | Extraterritorial | 2017 |
| Serene INK Aesthetics and Beauty Limited | Other services | 2024 |
| Serenity Farm Project Limited | Health & social care | 2018 |
| Serenity Health and Beauty Salon Ltd | Other services | 2012 |
| Serfix Property Solutions Limited | Construction | 2024 |
| Sergo Construction Ltd | Construction | 2024 |
| Serrah Consultancy Ltd | Information & communication | 2012 |
| Serrah Properties Limited | Real estate | 2016 |
| Serve and Savour Ltd | Hospitality | 2025 |
| Servi Point Ltd | Wholesale & retail | 2026 |
| Service Station Group Ltd | Wholesale & retail | 2021 |
| Service Systems Limited | Construction | 1984 |
| Serviceworx Limited | Information & communication | 2012 |
| Servitude Centre Community Interest Company | Information & communication | 2022 |
| Servotech Limited | Administrative & support | 2000 |
| SES Lakes Ltd | Administrative & support | 2018 |
| Sese Ltd | Wholesale & retail | 2023 |
| SET IT OFF Limited | Arts & recreation | 2017 |
| Seven 7 Properties Ltd | Real estate | 2021 |
| Seven Stars PUB Ltd | Hospitality | 2016 |
| Seven Trans Ltd | Transport & logistics | 2023 |
| Sevenfold Healthcare Consultancy Ltd. | Professional & scientific | 2014 |
| Seventh State Studio Ltd | Wholesale & retail | 2026 |
| SEVENTY7 Consulting Limited | Administrative & support | 2010 |
| SEW Bridal Love Limited | Other services | 2024 |
| SEWING4EVERYONE Limited | Wholesale & retail | 2010 |
| Sexy INK Ltd | Other services | 2024 |
| Seymour Street Limited | Households | 2026 |
| SF People Solutions Ltd | Other services | 2014 |
| SF Recycling Ltd | Wholesale & retail | 2024 |
| SF Skip Hire Ltd | Water & waste | 2023 |
| SFD Holdings Limited | Financial services | 2015 |
| Sfinx Consulting Ltd | Financial services | 2020 |
| Sfll Ltd | Health & social care | 2025 |
| SG Paving Ltd | Manufacturing | 2020 |
| SGH Mechanical Services Ltd | Construction | 2022 |
| SGI Trans Limited | Transport & logistics | 2023 |
| SGL Adventure Tours Ltd | Administrative & support | 2026 |
| SGP Legal Consultants Ltd | Professional & scientific | 2014 |
| SGS Commercial and Construction Services Ltd. | Construction | 2012 |
| SH Andrews Property Limited | Real estate | 2026 |
| SH Automotivez Limited | Wholesale & retail | 2026 |
| SH Groceries & OFF Licence Ltd | Wholesale & retail | 2021 |
| SH Promotions Limited | Arts & recreation | 2022 |
| SH Public Houses Limited | Hospitality | 2026 |
| SH Recoverys 24/7 Ltd | Water & waste | 2026 |
| Shabang Car Hire Limited | Administrative & support | 2019 |
| Shackleton & Co. Ltd. | Professional & scientific | 2016 |
| Shackleton Properties (Park Hall) Ltd | Wholesale & retail | 2021 |
| Shadow Heist Ltd | Hospitality | 2021 |
| Shadowfoxfashion Ltd | Information & communication | 2026 |
| Shadowline Strategies Ltd | Extraterritorial | 2026 |
| Shafo Fashion Ltd | Wholesale & retail | 2025 |
| Shah Inc. Limited | Wholesale & retail | 2025 |
| Shah Medicals Limited | Health & social care | 2019 |
| Shahab Ltd | Households | 2024 |
| Shahanahealthcare Limited | Health & social care | 2016 |
| Shaheen Global Logistics Ltd | Wholesale & retail | 2026 |
| Shahsalaar Ltd | Wholesale & retail | 2025 |
| Shak Wholesaler Limited | Wholesale & retail | 2025 |
| Shaks Retailer Limited | Wholesale & retail | 2025 |
| Shamaila’S World Ltd | Transport & logistics | 2025 |
| Shamsa Maqsood Limited | Real estate | 2025 |
| Shanel Services Ltd | Health & social care | 2024 |
| Shanshool Ltd | Construction | 2022 |
| Shanti Rose Ltd | Administrative & support | 2020 |
| Shantos Super Store Ltd | Wholesale & retail | 2026 |
| Shany HC Limited | Health & social care | 2025 |
| Shanzay Traders Ltd | Wholesale & retail | 2023 |
| Shanzay Traderz Ltd | Wholesale & retail | 2025 |
| Shar-Low Limited | Health & social care | 2017 |
| Sharanc Practitioner Limited | Public administration | 2022 |
| Share Factory Ltd | Transport & logistics | 2023 |
| Sharing the Vibe Limited | Real estate | 2018 |
| Sharjana Limited | Wholesale & retail | 2025 |
| Shark Cricket (UK) Limited | Wholesale & retail | 2010 |
| Sharvesh Arun Ltd | Wholesale & retail | 2018 |
| Shaw Commercial Services Limited | Wholesale & retail | 2023 |
| Shaw Engineering Ltd | Professional & scientific | 2024 |
| Shaw's & Company Estate Agents Limited | Real estate | 2015 |
| Shaw-Hand Health and Wellbeing CIC | Health & social care | 2025 |
| Shawarma Charcoal Grill Ltd | Hospitality | 2026 |
| Shazada Travels Ltd | Transport & logistics | 2024 |
| Sheepcraft Yarns Limited | Wholesale & retail | 2018 |
| Shekh Properties Ltd | Real estate | 2025 |
| Sheldon Electrical Services Ltd | Construction | 2022 |
| Shelton Auto Spares Limited | Wholesale & retail | 2003 |
| Shelton House Ltd | Real estate | 2022 |
| Shelton MOT Centre Limited | Wholesale & retail | 2015 |
| Shelton Pharmacy Limited | Wholesale & retail | 2025 |
| Shepherd P R Limited | Administrative & support | 2004 |
| Shepherd Street Chip Shop Limited | Hospitality | 2016 |