| Sheppeylogistics Limited | Transport & logistics | 2025 |
| Sheq-It-Out Ltd | Professional & scientific | 2020 |
| Sherider Ltd | Wholesale & retail | 2026 |
| Sherwin Rivers Limited | Manufacturing | 1969 |
| SHI Car Hire Ltd | Administrative & support | 2025 |
| Shian Business Services Ltd | Households | 2021 |
| Shian Homes Ltd | Real estate | 2024 |
| Shiba Kitchen Ltd | Hospitality | 2024 |
| Shield Heating & Plumbing Ltd | Construction | 2025 |
| Shifa Psychiatric Services Ltd | Health & social care | 2023 |
| Shikinah Limited | Health & social care | 2020 |
| Shilo K Ltd | Administrative & support | 2020 |
| Shima Health Limited | Health & social care | 2026 |
| Shimmy & Shhh Limited | Administrative & support | 2025 |
| Shine N Sparkle Limited | Administrative & support | 2021 |
| Shine on Shine Ltd | Administrative & support | 2025 |
| Shinglers Mower Services Ltd | Other services | 2012 |
| Shinning Sun Limited | Wholesale & retail | 2020 |
| Shinsean Automotive Ltd | Wholesale & retail | 2022 |
| Shiny Golden Car Wash Ltd | Administrative & support | 2025 |
| Shiplo Ltd | Wholesale & retail | 2025 |
| Shire Quality Care Ltd | Health & social care | 2023 |
| Shires Accountants Limited | Professional & scientific | 2022 |
| Shires Financial Services Limited | Financial services | 2023 |
| Shires Mechanical Services Limited | Construction | 2014 |
| Shires Weedfree Limited | Administrative & support | 2018 |
| Shirley's Care Services Limited | Health & social care | 2018 |
| Shirleys Transport Limited | Transport & logistics | 1964 |
| SHK Pharma Ltd | Health & social care | 2023 |
| SHM Freehold Ltd | Real estate | 2025 |
| SHM Investment Limited | Real estate | 2021 |
| Shmozone Ltd | Wholesale & retail | 2021 |
| Shoe Dyeing Direct Ltd | Wholesale & retail | 2024 |
| SHOE4 Sport Limited | Other services | 2022 |
| Shoes for YOU Limited | Wholesale & retail | 2018 |
| Shoes R US Limited | Wholesale & retail | 2023 |
| Shoo-In Ltd | Professional & scientific | 2013 |
| Shop Hang Online Ltd | Wholesale & retail | 2025 |
| Shop N Select Limited | Wholesale & retail | 2025 |
| Shopara Limited | Wholesale & retail | 2025 |
| Shopflics Ltd | Wholesale & retail | 2026 |
| Shoporio Ltd | Wholesale & retail | 2026 |
| Shoppe N Smile Limited | Wholesale & retail | 2013 |
| Shopperholic International Limited | Wholesale & retail | 2023 |
| Shopy Ltd | Wholesale & retail | 2023 |
| Shore Group Midlands Limited | Financial services | 2021 |
| Shore Mechanical Services Ltd | Construction | 1994 |
| Shore Thing Developments Ltd | Real estate | 2024 |
| Shoreline Marine Limited | Wholesale & retail | 2006 |
| Shot-Blast Stoke Ltd | Construction | 2021 |
| Shotts Property Limited | Real estate | 2015 |
| Shotts Residential Property Limited | Real estate | 2016 |
| Shovel Ltd | Transport & logistics | 2016 |
| Show ME AI Ltd | Information & communication | 2025 |
| Shraleybrook Brickwork Ltd | Construction | 2023 |
| Shree Hari Private Limited | Hospitality | 2025 |
| Shreeve Holdings Limited | Financial services | 2022 |
| Shropshire Coal & Logs Limited | Wholesale & retail | 2013 |
| Shropshire Coal Limited | Extraterritorial | 2013 |
| SHS Real Estate Ltd | Real estate | 2026 |
| Shtojber Ltd | Construction | 2020 |
| Shukers Pet Animal Feeds Ltd | Wholesale & retail | 2016 |
| Shumaila Creations Ltd | Wholesale & retail | 2026 |
| Shumons Food Ltd | Hospitality | 2026 |
| Shutt Pattern Makers Limited | Manufacturing | 2009 |
| Shutters 4 U Ltd | Wholesale & retail | 2017 |
| Shuumy Labs Limited | Manufacturing | 2023 |
| Si&Co Services Limited | Construction | 2026 |
| SIA Autos Stoke Ltd | Wholesale & retail | 2026 |
| Siais Maintenance Ltd | Construction | 2026 |
| Sialofficial Ltd | Wholesale & retail | 2025 |
| Sian Howitt Consulting Limited | Administrative & support | 2012 |
| Sidan Properties Limited | Real estate | 2013 |
| Siddall Spain Limited | Real estate | 2013 |
| SIG Services Ltd | Education | 2025 |
| Sigmaxsecurity Ltd | Administrative & support | 2026 |
| Sign of the Times Home Decor Ltd | Wholesale & retail | 2020 |
| Signability Limited | Manufacturing | 2017 |
| Signal Fire & Safety Limited | Wholesale & retail | 2003 |
| Signal Property Limited | Real estate | 2024 |
| Signalhr Ltd | Professional & scientific | 2026 |
| Signature Construction Midlands Limited | Construction | 2024 |
| Signature Estates Staffordshire Limited | Construction | 2018 |
| Signature Financial Services Group Limited | Financial services | 2025 |
| Signature Garages Limited | Wholesale & retail | 2021 |
| Signature Powder Coating Limited | Construction | 2025 |
| Signature Real Estate Ltd | Real estate | 2025 |
| Siitco Ltd | Wholesale & retail | 2025 |
| Sijuade Limited | Health & social care | 2024 |
| Siktech Ltd | Wholesale & retail | 2025 |
| Silixor Ltd | Wholesale & retail | 2025 |
| Silk Connexion Ltd | Information & communication | 2024 |
| Silly Rabbit Limited | Administrative & support | 2014 |
| Silver Group Logistic Limited | Transport & logistics | 2019 |
| Silvercrest Group Limited | Construction | 2020 |
| Silverdale Food & Wine Ltd | Wholesale & retail | 2024 |
| Silverdale Holdings Limited | Real estate | 2025 |
| SILVERH2O Limited | Health & social care | 2019 |
| Silverline Creations Limited | Wholesale & retail | 2009 |
| Silveroaks Companion Ltd | Health & social care | 2026 |