| Scalp Studio Ltd | Other services | 2020 |
| Scan MK Limited | Health & social care | 2019 |
| Scandico Limited | Wholesale & retail | 1998 |
| Scandinapan UK Ltd | Wholesale & retail | 2023 |
| Scane Dance Ltd | Education | 2022 |
| Scarlet Property Investments 2 Ltd | Real estate | 2026 |
| Scarlet Property Investments Ltd | Real estate | 2024 |
| Scarlett Property Investment Group Ltd | Financial services | 2025 |
| Scarlett Stays Limited | Hospitality | 2026 |
| Scaupe Ltd | Information & communication | 2024 |
| SCB Facilities Management Ltd | Construction | 2020 |
| SCC (S-O-T) Holdings Limited | Real estate | 2013 |
| SCD Property Management Ltd | Construction | 2022 |
| Scentimelti Ltd | Wholesale & retail | 2022 |
| SCG Groundworks Limited | Construction | 2020 |
| Schedule 2 Recruit Limited | Administrative & support | 2024 |
| Schlick Schwein Industries Ltd | Wholesale & retail | 2025 |
| Schui Graphics Limited | Professional & scientific | 2003 |
| Schwarze Group Limited | Wholesale & retail | 2017 |
| Scientific Glass Laboratories Limited | Manufacturing | 1966 |
| Scientific Horseshoeing Limited | Agriculture & fishing | 2021 |
| Scipe CIC | Health & social care | 2012 |
| SCO Elite Ltd | Administrative & support | 2025 |
| Scol Investments & Development Ltd | Real estate | 2024 |
| Scope Creative Ltd | Professional & scientific | 2024 |
| Scorpion FIX IT Ltd | Construction | 2025 |
| Scorpion Maintenance Ltd | Construction | 2025 |
| Scotia Property LLP | | 2015 |
| Scotia Road Garage Limited | Wholesale & retail | 2014 |
| Scott Holiday Cottages Limited | Hospitality | 2022 |
| Scott James Campbell Art Ltd | Arts & recreation | 2021 |
| SCP Events Consultancy Ltd | Professional & scientific | 2023 |
| Scragg's Properties Ltd | Real estate | 2016 |
| Screaming Head Productions Limited | Arts & recreation | 2018 |
| Screen Supplies Limited | Manufacturing | 2016 |
| Scrub-A-Dub Detailing Ltd | Wholesale & retail | 2025 |
| SDB International Engineering and Transport Ltd. | Transport & logistics | 2006 |
| SDE SPV a Limited | Real estate | 2026 |
| SDF Company Transport Ltd | Transport & logistics | 2022 |
| SDL Developments Ltd | Construction | 2019 |
| SDL Midlands Limited | Health & social care | 2021 |
| SDP Projects Ltd | Construction | 2024 |
| Sdprime Online Ltd | Wholesale & retail | 2022 |
| SDS Dental Ltd | Health & social care | 2013 |
| SDS Distribution Limited | Transport & logistics | 2019 |
| SDS Handyman Services Ltd | Construction | 2023 |
| Sea AYE Logistics Limited | Transport & logistics | 2023 |
| Sea AYE Properties Limited | Real estate | 2024 |
| Sea Bass Limited | Hospitality | 2024 |
| Sea Fish Bar 1 Ltd | Hospitality | 2026 |
| Seaford Limited | Hospitality | 2025 |
| Seaguest Ltd | Transport & logistics | 2024 |
| Sean Ryan Holdco Ltd | Professional & scientific | 2011 |
| Search Housing Association Limited | Construction | 1988 |
| Searchlight Care Services Limited | Health & social care | 2001 |
| Searchup Ltd | Administrative & support | 2016 |
| Seasonal Sales Ltd | Wholesale & retail | 2026 |
| Seasonal Sales Stoke Ltd | Wholesale & retail | 2026 |
| Seaton Holdings Limited | Administrative & support | 2006 |
| Sebella Capital Limited | Real estate | 2025 |
| Second Hand Tunstall Ltd | Wholesale & retail | 2025 |
| Second Look Stoke | Education | 2014 |
| Secret Embr Ltd | Hospitality | 2026 |
| Secret Sicilian Ltd | Hospitality | 2022 |
| Section 3-5 Ltd | Administrative & support | 2025 |
| Section 31 Limited | Construction | 2017 |
| Secure Futures Financial Advisory Ltd | Financial services | 2024 |
| Secure Needs Financial Services Limited | Professional & scientific | 2014 |
| Secure Park and Charge Stoke Limited | Transport & logistics | 2025 |
| Securecloud+ Limited | Information & communication | 2012 |
| Secureops Facilities Ltd | Administrative & support | 2026 |
| Securitrust Limited | Other services | 2024 |
| Security and Wealth Financial Recoveries Limited | Financial services | 2014 |
| Security Plus Limited | Other services | 1977 |
| Seddertone Designs Ltd | Information & communication | 2022 |
| Sedgemoor Serenity Services Ltd | Health & social care | 2018 |
| Sediqi Online Express Ltd | Wholesale & retail | 2024 |
| SEE Affinity Limited | Construction | 2025 |
| Seeley International (Europe) Limited | Manufacturing | 1988 |
| Seemy Works Limited | Construction | 2025 |
| Seentheos UN Limited | Information & communication | 2025 |
| Seeph Consultancy Ltd | Professional & scientific | 2024 |
| Sefton Asset Holding Limited | Construction | 2025 |
| SEI Electrical Contractors Limited | Construction | 2004 |
| SEI Property Limited | Construction | 2017 |
| SEI Security Ltd | Extraterritorial | 2018 |
| SEL AMZ UK Ltd | Wholesale & retail | 2025 |
| Select Insulation (Staffordshire) Limited | Extraterritorial | 2012 |
| Select Leads Limited | Information & communication | 2025 |
| Select Mabel Ltd | Construction | 2020 |
| Select Vehicle Repairs Limited | Wholesale & retail | 2006 |
| Sell My Minibus Limited | Wholesale & retail | 2013 |
| SELLONICS7 Ltd | Professional & scientific | 2025 |
| Selman Developments Limited | Construction | 2002 |
| Semper Fidelis (NW) Ltd | Professional & scientific | 2025 |
| Semper Hopkins Upholstery & Interiors Limited | Manufacturing | 2016 |
| SEN 1 Limited | Education | 2018 |
| Senelec International Limited | Wholesale & retail | 2023 |
| Senna Ltd | Transport & logistics | 2026 |
| Sentinel Security & Services Ltd | Administrative & support | 2024 |