| SAM Steele Rope Access Ltd | Construction | 2026 |
| SAM Turner Copywriting & Consulting (STC & C) LLP | | 2019 |
| Samantra Yoga Ltd | Arts & recreation | 2023 |
| Samar Traders UK Limited | Wholesale & retail | 2025 |
| Samara Company UK Limited | Wholesale & retail | 2022 |
| Sambezi and Sons Builders Ltd | Construction | 2024 |
| Sambrook (Burslem) Limited | Construction | 1947 |
| Samedi Solutions Ltd | Information & communication | 2024 |
| Samet Ayhan Ltd | Administrative & support | 2020 |
| Samet Transport Ltd | Transport & logistics | 2016 |
| Sami Direct UK Ltd | Wholesale & retail | 2026 |
| Sami Garage Ltd | Wholesale & retail | 2025 |
| Sami Safi Limited | Wholesale & retail | 2025 |
| Samjok Ltd | Professional & scientific | 2012 |
| Sammietech Ltd | Information & communication | 2020 |
| Samoord Multi-Synergy Limited | Transport & logistics | 2026 |
| Sampson Solutions Ltd | Administrative & support | 2026 |
| Samstan Limited | Hospitality | 2025 |
| Samuel Hobson Partners LLP | | 2020 |
| Samuel Makepeace (Newcastle and Stoke) Ltd | Real estate | 2018 |
| Samuel Makepeace Lettings Limited | Real estate | 2016 |
| SAN Automotive Limited | Wholesale & retail | 2024 |
| SAN Skin Ltd | Other services | 2026 |
| Sanan Enterprises Ltd | Wholesale & retail | 2026 |
| Sanar Properties Limited | Real estate | 2024 |
| Sanaya Limited | Hospitality | 2018 |
| Sanaz Properties Limited | Real estate | 2025 |
| Sanctuary Blasting Ltd | Manufacturing | 2024 |
| Sanctuary Commercial Ltd | Real estate | 2024 |
| Sanctuary SOS Limited | Construction | 2016 |
| Sanctuary Tax & Trust Services Ltd | Professional & scientific | 2017 |
| Sanctus HRC Housing CIC | Hospitality | 2024 |
| Sanctus ST. Mark's C.I.C. | Health & social care | 2014 |
| Sandbach Road 26/04/68 Limited | Extraterritorial | 2014 |
| Sandbeck Green Limited | Administrative & support | 2013 |
| Sanders & SON Holdings Ltd | Financial services | 2026 |
| Sandersfire International Ltd | Extraterritorial | 1995 |
| Sandhu DKP Logistics Ltd | Transport & logistics | 2026 |
| Sandon Ridge Solutions Ltd | Professional & scientific | 2024 |
| Sandon Stoves & Heating Ltd | Construction | 2022 |
| Sandy Lane Centre | Education | 2007 |
| Sandycroft Holdings Limited | Professional & scientific | 2008 |
| Sandycroft Projects Limited | Construction | 2012 |
| Sandyford Estates Limited | Real estate | 1999 |
| Sandyford Properties Limited | Real estate | 1964 |
| Sandyford Property Investments Limited | Real estate | 2018 |
| Sangam Restaurant Ltd | Hospitality | 2023 |
| Sanghera Healthcare Holdings Limited | Financial services | 2021 |
| Sanjeev's Enterprises Limited | Hospitality | 2009 |
| Sanjeev's Restaurant and Consultancy Services Limited | Hospitality | 2016 |
| Sant Building Group Ltd | Construction | 2026 |
| Sant Holdings Limited | Real estate | 2017 |
| Santon QC Limited | Professional & scientific | 2023 |
| Sanyarti Ltd | Wholesale & retail | 2024 |
| SAP 1 Limited | Financial services | 2015 |
| Sapiens Accountancy & Advisory Limited | Professional & scientific | 2026 |
| Sapling Associates Limited | Construction | 2000 |
| Sapphire Automotive Ltd | Wholesale & retail | 2025 |
| Sapphire Gardening Ltd | Administrative & support | 2023 |
| Sapphire-Minton Nursery Limited | Education | 2024 |
| SAQ Propertys Ltd | Real estate | 2024 |
| Sara International Trading (UK) Limited | Wholesale & retail | 2016 |
| Sara Shippey Ltd | Construction | 2026 |
| Sarah Batterton Planning Law Services Ltd | Professional & scientific | 2020 |
| Sarah King Consultancy Ltd | Professional & scientific | 2026 |
| Sarahs' Snack Shack Ltd | Hospitality | 2024 |
| Sari's Cars Limited | Wholesale & retail | 2025 |
| Sarim Kazmi Ltd | Wholesale & retail | 2023 |
| Saris Consulting Ltd | Information & communication | 2010 |
| Saris Property Ltd | Real estate | 2016 |
| Saris Technology Ltd | Information & communication | 2024 |
| Sarkar Property Solutions Ltd | Construction | 2025 |
| Saroopa Estates Limited | Real estate | 2021 |
| Sarum TM Limited | Transport & logistics | 2025 |
| Sarwpey 7KUR Ltd | Hospitality | 2026 |
| SAS Care Group Limited | Health & social care | 2022 |
| SAS Test and Repair Ltd | Wholesale & retail | 2020 |
| Sasha Leisure Ltd | Hospitality | 2021 |
| Sastruga Designs Limited | Wholesale & retail | 2024 |
| Savage & Sons Property Ltd | Real estate | 2023 |
| Savage & Williams Limited | Professional & scientific | 2018 |
| Save Safe Shop Ltd | Wholesale & retail | 2015 |
| Savii Estates Limited | Construction | 2017 |
| Savorsip Straws Ltd | Manufacturing | 2025 |
| SAW Legal Services Ltd | Professional & scientific | 2022 |
| Sayidzay Brothers Ltd | Wholesale & retail | 2023 |
| SB Building & Groundworks Ltd | Construction | 2024 |
| SB Constructions Stoke Ltd | Construction | 2026 |
| SB Plastics UK Limited | Wholesale & retail | 2010 |
| SB Project Interior Ltd | Construction | 2016 |
| SB Property Development and Rentals Limited | Real estate | 2015 |
| SB Social Care Management Limited | Health & social care | 2016 |
| SBD Holdings Limited | Wholesale & retail | 2015 |
| SBF Trans Ltd. | Transport & logistics | 2016 |
| SBH Trades Ltd | Wholesale & retail | 2025 |
| SBH Transport Services Ltd | Transport & logistics | 2017 |
| SBP Stoke Limited | Other services | 2015 |
| SC DRY Cleaning Ltd | Other services | 2018 |
| Scaffolding Contractors Limited | Construction | 1995 |
| Scaliwagz Limited | Health & social care | 2001 |