| S&P Clinical Services UK Ltd | Health & social care | 2024 |
| S&P Consulting Services Ltd | Administrative & support | 2021 |
| S&W Vehicle Hire Ltd | Administrative & support | 2009 |
| S. & J. Wright & Sons (Grocers) Limited | Real estate | 1976 |
| S. J. Walchester Environmental Services Ltd | Water & waste | 2021 |
| S. J. Walchester Transport Ltd | Transport & logistics | 2021 |
| S. Jennings Group Limited | Professional & scientific | 2005 |
| S.A. Platt (Builders) Limited | Construction | 1996 |
| S.A. Platt Holdings Limited | Financial services | 2021 |
| S.A. Platt Property Limited | Real estate | 2021 |
| S.A.F.F Services Limited | Information & communication | 2019 |
| S.A.R. Holdings (SOT) Limited | Real estate | 2019 |
| S.Ajala Limited | Wholesale & retail | 2026 |
| S.Bell Construction Management Ltd | Construction | 2019 |
| S.C.C.S-Stoke Ltd. | Administrative & support | 2017 |
| S.D Fire and Security Limited | Public administration | 2026 |
| S.H. Johnson and Company Limited | Professional & scientific | 1990 |
| S.Jennings Limited | Wholesale & retail | 1912 |
| S.O.C Childcare Ltd | Health & social care | 2021 |
| S.O.T Couriers Ltd | Transport & logistics | 2010 |
| S.R. Utilities Training Ltd | Real estate | 2014 |
| S.R.T Enterprises Limited | Wholesale & retail | 2023 |
| S.Robinson & Co.Limited | Real estate | 1927 |
| S2 Trading Ltd | Wholesale & retail | 2025 |
| S2P Solutions Ltd | Professional & scientific | 2025 |
| S3AAK Ltd | Wholesale & retail | 2022 |
| SA Global Solutions Ltd | Wholesale & retail | 2026 |
| SA Infrastructure Solutions Ltd | Information & communication | 2021 |
| SA Marine Surveys Ltd | Wholesale & retail | 2024 |
| SA Properties SOT Limited | Real estate | 2024 |
| SA Specialist Cars SOT Limited | Wholesale & retail | 2022 |
| SA Stoke Ltd | Wholesale & retail | 2017 |
| SAA Properties (North) Limited | Real estate | 2024 |
| Saad & Saqi Travels Ltd | Transport & logistics | 2024 |
| Sab-Zee Care Limited | Health & social care | 2024 |
| Sabaoth Ltd | Health & social care | 2026 |
| Sabella Home Limited | Wholesale & retail | 2018 |
| Saber-Tech IT Ltd | Wholesale & retail | 2021 |
| Sabiha Design Studio Ltd | Professional & scientific | 2025 |
| Sabit Engineering Solutions Limited | Professional & scientific | 2022 |
| Sabz Trent Motors Ltd | Wholesale & retail | 2026 |
| Sacred Heart Retails Ltd | Wholesale & retail | 2025 |
| Sadat Enterprises Ltd | Wholesale & retail | 2021 |
| Saddat Motors Ltd | Wholesale & retail | 2026 |
| Saddozai Bros Limited | Wholesale & retail | 2025 |
| Sadia Jabeen Properties Ltd | Households | 2021 |
| SAE Property Maintenance Group (UK) Ltd | Construction | 2025 |
| Safari Care Limited | Health & social care | 2025 |
| Safcom Ltd | Professional & scientific | 2018 |
| Safe 2 Race Ltd | Wholesale & retail | 2021 |
| Safe Access Solutions (Scaffolding) Limited | Construction | 2014 |
| Safe and Sealed Ltd | Professional & scientific | 2025 |
| Safe Haven Home Care Ltd | Health & social care | 2026 |
| Safe Haven Residential Child Care Ltd | Extraterritorial | 2024 |
| Safe Space Education CIC | Education | 2026 |
| Safe to Shine CIC | Public administration | 2025 |
| Safeguard Transport Ltd | Transport & logistics | 2022 |
| Safeguarding People Limited | Administrative & support | 2013 |
| Safer Transition Ltd | Transport & logistics | 2026 |
| Safety Assessment Solutions Ltd | Professional & scientific | 2012 |
| Safety Mate Limited | Wholesale & retail | 2015 |
| Safety Pro Limited | Information & communication | 2025 |
| Safi Design Ltd | Information & communication | 2025 |
| Saghir Express (Take Away) Limited | Hospitality | 2018 |
| Saghir Express Limited | Hospitality | 2017 |
| Sahbio Property Ltd | Real estate | 2025 |
| Sahota Property Holdings Limited | Real estate | 2025 |
| Sailboat Rigging Systems Limited | Wholesale & retail | 2026 |
| Saim Auto TRD Ltd | Wholesale & retail | 2024 |
| Saiman Properties Limited | Real estate | 2019 |
| Saimzainaida Ltd | Information & communication | 2025 |
| Saindak Construction Ltd | Construction | 2019 |
| Saint Luke's Construction Limited | Construction | 2012 |
| Saji Jasmi PVT Limited | Health & social care | 2014 |
| Sajkiru Ltd | Wholesale & retail | 2022 |
| SAK Distributions Limited | Wholesale & retail | 2026 |
| Sakb Building Solutions Ltd | Real estate | 2015 |
| Saki Stoke Ltd | Real estate | 2024 |
| Sakura Wellness Estates Ltd | Real estate | 2025 |
| Salahuddin Resturant Ltd | Hospitality | 2025 |
| Salaria Power Services Limited | Professional & scientific | 2017 |
| Salartech Ltd | Wholesale & retail | 2025 |
| Sale Edwards Property Limited | Real estate | 2025 |
| Sales Alliance Ltd | Administrative & support | 2022 |
| Salih & Joy Consultants Limited | Professional & scientific | 2016 |
| Salim Khan Accounting Ltd | Administrative & support | 2013 |
| Salixx Homes Ltd | Real estate | 2021 |
| Sally Anna's Limited | Administrative & support | 2004 |
| Salsons Engineering Ltd | Construction | 2018 |
| Salt Contractors Ltd | Construction | 2025 |
| Salt Investments Limited | Real estate | 2011 |
| Salt Systems Limited | Construction | 2021 |
| Saltash Limited | Wholesale & retail | 1997 |
| Saltatio Limited | Real estate | 2019 |
| Salthouse Pet Boarding Limited | Agriculture & fishing | 2025 |
| Salvation Avenue Ltd | Wholesale & retail | 2025 |
| Salvation Security Protection Limited | Administrative & support | 2025 |
| Salway Excavations Limited | Water & waste | 2017 |
| SAM Barcham Ltd | Professional & scientific | 2019 |
| SAM Bloor Producer Ltd | Information & communication | 2023 |