| Star Movement Media Limited | Wholesale & retail | 2025 |
| Star Pizza Eccleshall Limited | Hospitality | 2020 |
| Stars Awaken Limited | Wholesale & retail | 2025 |
| Starsea Industrial Ltd | Professional & scientific | 2006 |
| Start and Scale Technology Ltd | Information & communication | 2025 |
| Startin Sales Solutions Ltd | Professional & scientific | 2018 |
| Station Road Biddulph 2013 Limited | Real estate | 2013 |
| Statistics 24 Limited | Information & communication | 2016 |
| Stavian Limited | Health & social care | 2011 |
| Staynest Lettings Ltd | Hospitality | 2025 |
| STD Retailer Ltd | Wholesale & retail | 2016 |
| Steadblast Limited | Construction | 2009 |
| Steady Ground AP Ltd | Education | 2026 |
| Steel Door Company Ltd | Construction | 2023 |
| Steel Engineering Services Limited | Construction | 2018 |
| Steel Service Centre Limited | Manufacturing | 2000 |
| Steels Safety Training Solutions Ltd | Education | 2022 |
| Stella Athanatou Ltd | Wholesale & retail | 2023 |
| Stem Cell Clinics Ltd | Health & social care | 2017 |
| Step Easy Ltd | Health & social care | 2011 |
| Steph Morgan Consulting Ltd | Information & communication | 2020 |
| Stephanie Hill Equestrian Limited | Other services | 2020 |
| Stephen Joynson Contracts Limited | Construction | 2002 |
| Stepping Stones Day Nursery (Clay Cross) Limited | Education | 2014 |
| Stepping Stones Day Nursery (Heath Hayes) Limited | Extraterritorial | 2007 |
| Steve Crocker Consultancy Ltd | Professional & scientific | 2023 |
| Steve Davis Land and Property Consultancy Ltd | Professional & scientific | 2019 |
| Steve Priestley Media Ltd | Arts & recreation | 2022 |
| Steve Waddison & SON Ltd | Administrative & support | 2016 |
| Stevenson James Recruitment Partners Limited | Administrative & support | 2018 |
| Steward Chemical Ltd | Professional & scientific | 2014 |
| Stewart Phillips Partnership LLP | | 2015 |
| Stewart's Engineering Ltd | Construction | 2026 |
| Stewise Ltd | Wholesale & retail | 2025 |
| Stoke Trampoline and Gymnastics LLP | | 2018 |
| Stollis Professional Services Ltd | Administrative & support | 2025 |
| Stone Computers Limited | Professional & scientific | 2020 |
| Stone Engineering Services Limited | Professional & scientific | 2026 |
| Stone Junction Limited | Professional & scientific | 2006 |
| Stone Lawn Tennis Club Limited | Arts & recreation | 1920 |
| Stone Master Marathoners CIC | Arts & recreation | 2024 |
| Stone Premier Ltd | Wholesale & retail | 2021 |
| Stone Research Limited | Professional & scientific | 2019 |
| Stone Road Management Limited | Households | 2013 |
| Stone Technologies Group Limited | Financial services | 2019 |
| Stone Technologies Limited | Manufacturing | 1991 |
| Stonehouse Gardens Management Company Limited | Households | 2016 |
| Stonelin Communications Limited | Information & communication | 2015 |
| Stonemeadow Limited | Construction | 2024 |
| Stonystack Ltd | Wholesale & retail | 2025 |
| Stonystack Property Limited | Real estate | 2025 |
| Stop and Stare Limited | Professional & scientific | 2016 |
| Stopcheckfiresafe Limited | Professional & scientific | 2022 |
| Storm Animals Limited | Agriculture & fishing | 2020 |
| Stormbreakers Ltd | Wholesale & retail | 2025 |
| Stormforce Roofing Stafford Ltd | Construction | 2026 |
| Stormrox Ltd | Arts & recreation | 2025 |
| Stormseal Conservatories Limited | Construction | 1996 |
| Stormworks Garage Limited | Wholesale & retail | 2020 |
| Stowe Services and Consulting Ltd | Real estate | 2012 |
| Straight White Teeth Limited | Health & social care | 2008 |
| Strategic Intent Limited | Professional & scientific | 2006 |
| Strategic People Partners Ltd | Professional & scientific | 2025 |
| Stratos Marketing Group Ltd | Information & communication | 2025 |
| Stratton Roofline Solutions Ltd | Construction | 2025 |
| Streatlam Ltd | Construction | 2020 |
| Stretton Lodge Day Nursery Limited | Education | 2015 |
| Strictly Surveying Ltd | Professional & scientific | 2025 |
| Strieve X Limited | Information & communication | 2025 |
| Strikalite Batteries Limited | Manufacturing | 1998 |
| Strolll Limited | Information & communication | 2019 |
| Strut Hairdressing (UK) Limited | Other services | 2024 |
| Sttop Filters Limited | Manufacturing | 1997 |
| Stubbs Partners Limited | Agriculture & fishing | 2013 |
| Stuburt Investments Limited | Real estate | 2020 |
| Studio NO 55 Ltd | Wholesale & retail | 2024 |
| Studio Trafeli LLP | | 2026 |
| STUDIO51 Music Limited | Information & communication | 2025 |
| STUDIO51 Solutions Ltd | Information & communication | 2025 |
| Sturgess Developments Ltd | Real estate | 2023 |
| Suade Ltd | Real estate | 2015 |
| Sujan PC Limited | Professional & scientific | 2013 |
| Sumei Electronic Technology Co., Ltd | Wholesale & retail | 2021 |
| Summer International Corporation Limited | Wholesale & retail | 2024 |
| Summit Financials Ltd | Professional & scientific | 2023 |
| Sun Panda. Ltd | Wholesale & retail | 2021 |
| Sun YUN Ltd | Hospitality | 2016 |
| Sunair Houseware Co., Ltd | Extraterritorial | 2014 |
| Suncroft Strategic Finance Partners Limited | Professional & scientific | 2025 |
| Sunday Morning Studio Ltd | Information & communication | 2025 |
| Sunew Ltd | Wholesale & retail | 2023 |
| Sunflower Recycling Limited | Other services | 2022 |
| Sunmes UK Ltd | Wholesale & retail | 2025 |
| Sunningdale Classics Limited | Wholesale & retail | 2017 |
| Sunny Stafford Limited | Hospitality | 2015 |
| Sunnyside Drinks Co Ltd | Manufacturing | 2023 |
| Sunnytech Limited | Wholesale & retail | 2000 |
| Sunrange Ltd | Wholesale & retail | 2021 |
| Sunset Campers Ltd | Administrative & support | 2020 |
| Sunshine Care Stafford Limited | Health & social care | 2017 |