| Sunshow Technology Co., Ltd | Manufacturing | 2025 |
| Suntensh Trading Co., Ltd | Wholesale & retail | 2022 |
| Sunviet International (UK) Ltd | Wholesale & retail | 2026 |
| Sunward Trading Limited | Wholesale & retail | 2025 |
| Super L Media Ltd | Wholesale & retail | 2024 |
| Superior Engineering Services Ltd | Construction | 2018 |
| Superior Home Development Limited | Construction | 2011 |
| Supplies Partner Ltd | Wholesale & retail | 2019 |
| Supply Chain Pro Limited | Professional & scientific | 2025 |
| Support Staffordshire | Health & social care | 2014 |
| Supramolecular Cell Biotechnology Research Center Co., Ltd. | Wholesale & retail | 2025 |
| Supreme Energy Group Co., Ltd | Extraterritorial | 2016 |
| Sure Equipment (Plant Services) Ltd | Manufacturing | 2022 |
| Sure Equipment (Spares) Limited | Wholesale & retail | 1991 |
| Sure Equipment Sales & Rentals Ltd | Wholesale & retail | 2024 |
| Sureset Paving Limited | Construction | 2018 |
| Suretex Composite Co., Ltd | Extraterritorial | 2012 |
| Surpass Machine and Tool Co., Ltd | Extraterritorial | 2016 |
| Surprise International UK Group Co., Ltd | Mining & quarrying | 2023 |
| Surrey Life Science Research Co Ltd | Extraterritorial | 2017 |
| Sustainable Energy Developments Limited | Financial services | 2017 |
| Sustainable Energy Holdings Limited | Financial services | 2020 |
| Sustainable Energy Solutions Eco Limited | Professional & scientific | 2022 |
| Sustainable Sport CIC | Arts & recreation | 2020 |
| Sutton’S Energy Management Ltd | Construction | 2023 |
| Sv&Dv Properties Limited | Real estate | 2025 |
| SW Records UK Ltd | Wholesale & retail | 2020 |
| Swan Court (Church Eaton) Limited | Households | 1997 |
| Swift Abrasives Ltd | Manufacturing | 2026 |
| Swift Consultancy Services Limited | Professional & scientific | 2025 |
| Swiftglobe Limited | Wholesale & retail | 2025 |
| Swim Power CIC | Education | 2025 |
| Swimwell Academy Ltd | Education | 2021 |
| Swimwell Ltd | Education | 2022 |
| Swinnerton Transport Limited | Transport & logistics | 1985 |
| Swiss Jinjian Meikang International Co., Ltd. | Wholesale & retail | 2025 |
| Switchsave Ltd | Wholesale & retail | 2025 |
| Switon Holdings Ltd | Financial services | 2023 |
| Syeda Aleema Zahra Limited | Professional & scientific | 2022 |
| Sykes Media Limited | Information & communication | 2023 |
| Sylheti Balti Limited | Hospitality | 2026 |
| Sylo Productions England Ltd | Other services | 2022 |
| Sylvan Wavelyn International Trading Limited | Wholesale & retail | 2025 |
| Sylvien Hotels Management Ltd | Hospitality | 2024 |
| Synergia Coaching Limited | Professional & scientific | 2008 |
| Synergise Business Solutions Limited | Administrative & support | 2021 |
| Synergy Golf Performance Limited | Health & social care | 2025 |
| Synergy Project Resources Limited | Professional & scientific | 2011 |
| Synergy Warehousing Solutions Ltd | Transport & logistics | 2023 |
| Synthbridge Ltd | Wholesale & retail | 2025 |
| Sysmtech Ltd | Construction | 2019 |
| Systech Controls Limited | Manufacturing | 1994 |
| System Design LAB UK Ltd | Wholesale & retail | 2017 |
| Systematic Alpha Ltd | Financial services | 2026 |
| Systems Engineering Services Ltd | Other services | 2019 |
| Systemsville Systems Engineering Solutions Ltd | Manufacturing | 2016 |
| T & H Beauty Ltd | Other services | 2012 |
| T & JW Holdings Limited | Households | 2023 |
| T & R Marshall Properties Ltd | Real estate | 2025 |
| T & S Crafting Studio Limited | Wholesale & retail | 2024 |
| T & S Swim School LLP | | 2026 |
| T Buck Seafoods Limited | Wholesale & retail | 2015 |
| T C Fencing & Landscaping Limited | Administrative & support | 2021 |
| T D & D Limited | Information & communication | 2014 |
| T I Anode (UK) PVT Ltd | Professional & scientific | 2006 |
| T J B Property Services Limited | Construction | 2017 |
| T Mcadams Security Training Solutions Ltd | Professional & scientific | 2012 |
| T Nails Stafford Limited | Other services | 2018 |
| T Potter Geophysical Solutions Limited | Professional & scientific | 2016 |
| T Shaw Utilities Ltd | Construction | 2023 |
| T&D Domestic Electrician Services Limited | Construction | 2021 |
| T,C&M. Limited | Transport & logistics | 2023 |
| T. C. Interiors Limited | Construction | 2000 |
| T. Moore Building Services Limited | Construction | 2014 |
| T.C Legal Ltd | Professional & scientific | 2026 |
| T.E. Plumbing & Tiling Ltd | Manufacturing | 2017 |
| T.J. Burrows Ltd | Construction | 2016 |
| T.L. Property Investments Limited | Real estate | 2019 |
| T.W.J. Carpentry Services Ltd | Construction | 2012 |
| T100 Risk Systems Limited | Information & communication | 2016 |
| T3000 Consultants Limited | Professional & scientific | 2019 |
| TA Multiservices Limited | Administrative & support | 2023 |
| TAB Healthcare Management Ltd | Health & social care | 2013 |
| TAD One Ltd | Real estate | 2022 |
| Tail Blazers Ltd | Extraterritorial | 2023 |
| Tailored Air Group Limited | Financial services | 2024 |
| Tailored Air Limited | Construction | 2019 |
| Tailored Branding Limited | Professional & scientific | 2003 |
| Tailored Property Renovations Limited | Real estate | 2024 |
| Tailored Signal Design Ltd | Other services | 2010 |
| Tails and Feathers Ltd | Wholesale & retail | 2014 |
| Taizhou Huangyan Aigo Import&Export Co., Ltd | Manufacturing | 2023 |
| Taizhou Hugo Chemicals Co., Ltd. | Wholesale & retail | 2020 |
| Taker Splash Ltd | Education | 2024 |
| Talc Trading Ltd | Wholesale & retail | 2023 |
| Talla Holdings Limited | Wholesale & retail | 2021 |
| Tallent Carpentry Construction Ltd | Construction | 2026 |
| Tallent Properties Ltd | Real estate | 2026 |
| Tamioz Import and Export Company Ltd | Wholesale & retail | 2023 |
| Tamworth Toys and Collectables Limited | Wholesale & retail | 2022 |