| Specialist Recruitment Services Limited | Administrative & support | 2001 |
| Spectacoma Limited | Wholesale & retail | 2024 |
| Spectrum Music Limited | Arts & recreation | 2019 |
| Spencer the Jeweller Limited | Wholesale & retail | 2012 |
| SPG Brookes Properties Limited | Real estate | 2006 |
| SPG Trading Ltd | Wholesale & retail | 2020 |
| SPH Electrical Ltd | Construction | 2023 |
| SPI UK Asset Company Limited | Wholesale & retail | 2017 |
| Spice Island Midlands Ltd | Hospitality | 2019 |
| Spice of Stafford Ltd | Hospitality | 2025 |
| Spiderweb Software Ltd | Information & communication | 2009 |
| Spiers Services Ltd | Real estate | 2015 |
| Spin Leisure Limited | Professional & scientific | 2003 |
| Spindle Creative Limited | Arts & recreation | 2018 |
| Spirava International Limited | Wholesale & retail | 2025 |
| Spiro-Gills Thermal Products Ltd | Manufacturing | 2016 |
| SPL Design and Build Limited | Construction | 2013 |
| Splash Vibe Limited | Professional & scientific | 2025 |
| Splice Limited | Arts & recreation | 2013 |
| Sport Prints Limited | Wholesale & retail | 2018 |
| Sports Nutrition Supplies Limited | Health & social care | 2025 |
| Sportsnips Ltd | Wholesale & retail | 2016 |
| Spritelea Limited | Professional & scientific | 2011 |
| SPS Contracts Ltd | Construction | 2022 |
| Square House Horsebox Hire Ltd | Administrative & support | 2022 |
| Squared Path Ltd | Information & communication | 2026 |
| Squeaky Queenz Ltd | Administrative & support | 2024 |
| Squidge Rentals Limited | Hospitality | 2025 |
| Srgr PUB Limited | Hospitality | 2026 |
| SRH2013 Limited | Extraterritorial | 2013 |
| SRI SKR Ltd | Real estate | 2025 |
| SRM Family Property Ltd | Real estate | 2025 |
| Srpc Limited | Other services | 2021 |
| SS Health Advisory Ltd | Professional & scientific | 2026 |
| SSC Parts Ltd | Wholesale & retail | 2023 |
| Sspa Events Limited | Arts & recreation | 2017 |
| SSS (UK) Int'L Secretary Co., Ltd | Extraterritorial | 2021 |
| ST Edwards Park Management Company Limited | Households | 2002 |
| ST Engineers Ltd | Professional & scientific | 2026 |
| ST Leonards Grid Switchgear Limited | Manufacturing | 1965 |
| ST Peters Pre-School (Stafford) | Education | 2003 |
| ST Thomas' Priory Management Limited | Real estate | 2007 |
| ST. Bedes School Limited | Education | 1937 |
| ST. Michaels Court (Colwich) Management Limited | Households | 1997 |
| ST17 Property Ltd | Real estate | 2025 |
| ST18 Limited | Construction | 1976 |
| ST9 Investigations Limited | Administrative & support | 2015 |
| STA Property Development Ltd | Construction | 2023 |
| Stable Park Holiday Park & Caravan Storage Ltd | Transport & logistics | 2023 |
| Stadia Sports Ltd | Extraterritorial | 2023 |
| Staff Plumbing Ltd | Wholesale & retail | 2014 |
| Staff Scouts UK Limited | Administrative & support | 2025 |
| Staffing Science Limited | Information & communication | 2022 |
| Stafford & Wolverhampton Properties Limited | Households | 2021 |
| Stafford Air Conditioning Services Limited | Construction | 2002 |
| Stafford and Cannock League of Hospital Friends | Hospitality | 1990 |
| Stafford and District Bereavement and Loss Support Service | Health & social care | 2010 |
| Stafford Angling Centre Ltd | Wholesale & retail | 2020 |
| Stafford Aquatics Ltd | Wholesale & retail | 2018 |
| Stafford Bags Limited | Wholesale & retail | 2025 |
| Stafford Bakehouse Limited | Wholesale & retail | 2015 |
| Stafford BC Trading Limited | Arts & recreation | 2024 |
| Stafford Best Barber(Bridge Street) Ltd | Other services | 2021 |
| Stafford Best Pizza Ltd | Hospitality | 2021 |
| Stafford Boat Club Limited | Arts & recreation | 1977 |
| Stafford Burger Trading Ltd | Hospitality | 2019 |
| Stafford Cabs Ltd | Transport & logistics | 2017 |
| Stafford Cafe Ltd | Hospitality | 2025 |
| Stafford Car Sales Ltd | Wholesale & retail | 2026 |
| Stafford Caravan Sales Ltd | Wholesale & retail | 2025 |
| Stafford Cards Ltd | Wholesale & retail | 2024 |
| Stafford Carpets & Flooring Ltd | Wholesale & retail | 2024 |
| Stafford Chiropractic Clinic Limited | Health & social care | 2017 |
| Stafford Community Food Distribution Hub CIC | Hospitality | 2022 |
| Stafford Convenience Store Limited | Wholesale & retail | 2024 |
| Stafford Couriers Limited | Transport & logistics | 2025 |
| Stafford Decorating Centre Ltd | Wholesale & retail | 2016 |
| Stafford Discount Store Ltd | Wholesale & retail | 2025 |
| Stafford Dyslexia Support Ltd | Education | 2014 |
| Stafford Electrical Limited | Construction | 2004 |
| Stafford Engineering Services Limited | Manufacturing | 2000 |
| Stafford Essence Limited | Hospitality | 2017 |
| Stafford Fireplaces and Stoves Ltd | Wholesale & retail | 2014 |
| Stafford Flower Shack Ltd | Wholesale & retail | 2021 |
| Stafford GAS MAN Ltd | Construction | 2018 |
| Stafford Grass Cutting Limited | Administrative & support | 2024 |
| Stafford Green Pizza Ltd | Hospitality | 2026 |
| Stafford Gymnastics Club Limited | Arts & recreation | 2012 |
| Stafford Hand Car Wash Ltd | Wholesale & retail | 2019 |
| Stafford Housing Ltd | Real estate | 2024 |
| Stafford Industrial Supplies Limited | Wholesale & retail | 2004 |
| Stafford Instruments Limited | Manufacturing | 1986 |
| Stafford Joinery Limited | Manufacturing | 2017 |
| Stafford Kitchens Ltd | Construction | 2024 |
| Stafford Kurdish Barbers Ltd | Other services | 2023 |
| Stafford Local Pizza Ltd | Hospitality | 2019 |
| Stafford Market Ltd | Wholesale & retail | 2021 |
| Stafford Masonic Hall Company Limited(The) | Professional & scientific | 1953 |
| Stafford Motorcycles Limited | Wholesale & retail | 2003 |
| Stafford Music School Ltd | Education | 2015 |