| SL Assist Ltd | Health & social care | 2015 |
| Slabify Ltd | Wholesale & retail | 2024 |
| Slapramps 1 Ltd | Manufacturing | 2021 |
| Slices Pizza Limited | Hospitality | 2019 |
| SLP Automotive Ltd | Wholesale & retail | 2025 |
| SLT Agricultural Storage Limited | Transport & logistics | 2025 |
| Sm&Rt Circles Ltd | Public administration | 2015 |
| Small Blue Planet Software Ltd. | Information & communication | 2017 |
| Small Island Trader Limited | Transport & logistics | 1997 |
| Smart AS a Limited | Wholesale & retail | 2014 |
| Smart Cars Taxis LLP | | 2017 |
| Smart Choice Carefree (U.K) Limited | Professional & scientific | 2025 |
| Smart Junbo Hill Ltd | Wholesale & retail | 2025 |
| Smart Logistical Solutions Ltd | Transport & logistics | 2023 |
| Smart Marketing Works Limited | Administrative & support | 2009 |
| Smart Ohm'Z Ltd | Construction | 2018 |
| Smart Property Homes Ltd | Real estate | 2006 |
| Smart Property Stafford Limited | Real estate | 2013 |
| Smart Systems Engineering Ltd | Professional & scientific | 2014 |
| Smartatten Ltd | Wholesale & retail | 2024 |
| Smessageit Ltd | Other services | 2020 |
| Smithfield Mews Management Company Limited | Real estate | 2005 |
| Smithfield Partnership Ltd | Construction | 2016 |
| SMK Global Trading Co., Ltd | Extraterritorial | 2014 |
| Smnsica Limited | Transport & logistics | 2025 |
| Smoker Choice Stafford Ltd | Wholesale & retail | 2025 |
| Smooth Homes Limited | Real estate | 2023 |
| SMT Electrotech Co., Limited | Wholesale & retail | 2025 |
| Smyrna Ltd | Professional & scientific | 2019 |
| Snac Limited | Hospitality | 2022 |
| Snagr Software Ltd | Information & communication | 2008 |
| Snap Badger Limited | Administrative & support | 2008 |
| SNG Cargo Trading Co., Limited | Wholesale & retail | 2023 |
| Snowco Ingredients Ltd | Extraterritorial | 2019 |
| Snowytrees Ltd | Hospitality | 2015 |
| SNP Industry Co., Ltd. | Extraterritorial | 2021 |
| SO Gorgeous Limited | Other services | 2010 |
| Soaaaap Trading Limited | Information & communication | 2021 |
| Soalmed Ltd | Health & social care | 2026 |
| Soccer Box International Limited | Wholesale & retail | 2020 |
| Social by HAN Ltd | Professional & scientific | 2025 |
| Socitm | Other services | 2002 |
| Socitm Commercial Ltd | Other services | 2022 |
| Sofcris Ltd | Construction | 2023 |
| SOH GD Ltd | Real estate | 2026 |
| Soho Vintage Limited | Wholesale & retail | 2020 |
| Sojoin Leisure Products Co., Ltd | Wholesale & retail | 2025 |
| Solace Starlight Limited | Wholesale & retail | 2026 |
| Solace Support Ltd | Health & social care | 2022 |
| Solanda Global Limited | Information & communication | 2025 |
| Solar Spares Direct Limited | Manufacturing | 2011 |
| Solar Wise Limited | Wholesale & retail | 2018 |
| Solarquill UK Ltd | Wholesale & retail | 2025 |
| Solemn Industrial Development Co., Ltd | Extraterritorial | 2019 |
| Solidfit Retail Ltd | Wholesale & retail | 2025 |
| Solidrock Care Services Limited | Health & social care | 2025 |
| Sollumstice Ltd | Wholesale & retail | 2025 |
| Solutionz Kept Simple Limited | Professional & scientific | 2023 |
| Solvex Pharmaceuticals Co Ltd | Manufacturing | 2025 |
| Somerchurch Properties Limited | Real estate | 2003 |
| Somerford Hall Limited | Hospitality | 2011 |
| Soneterlove Limited | Wholesale & retail | 2025 |
| Song Siam Thai Limited | Other services | 2016 |
| Songkran Trading Limited | Wholesale & retail | 2019 |
| Soorma Ltd | Wholesale & retail | 2024 |
| Sophie Anna Holdings Ltd | Financial services | 2022 |
| Sophie Anna Limited | Wholesale & retail | 2020 |
| Sophlee Limited | Information & communication | 2008 |
| Sorbus Partners LLP | | 2012 |
| Sorbus Projects Ltd | Administrative & support | 2022 |
| Sorbus.Org Ltd | Administrative & support | 2022 |
| Soro Rebus Freelance Writing Ltd | Information & communication | 2025 |
| Souled FP Limited | Financial services | 2024 |
| Soumpou International Trading Co., Ltd | Wholesale & retail | 2024 |
| Source and Supply Midlands Limited | Other services | 2019 |
| South Staffordshire Athletic Ltd | Arts & recreation | 2025 |
| South Staffs Consultancy Ltd | Professional & scientific | 2020 |
| Southan Antiques Limited | Wholesale & retail | 2019 |
| Southan Bistro Limited | Hospitality | 2025 |
| Sovereign Car Centre Limited | Wholesale & retail | 2003 |
| Sovereign Chemicals Limited | Manufacturing | 1996 |
| Sovereign Mortgages Limited | Financial services | 2022 |
| Soyasa Foodlinks Ltd | Wholesale & retail | 2020 |
| Soyasa Landmarks & IT Solutions Ltd | Information & communication | 2020 |
| Soyasa Limited | Wholesale & retail | 2013 |
| SP Production Services Ltd | Arts & recreation | 2021 |
| Space BRO Trading Co., Ltd | Wholesale & retail | 2024 |
| Space Technology International Services Co., Ltd | Manufacturing | 2021 |
| Sparrow's Nests Property Limited | Real estate | 2015 |
| Sparrows Nests Holdings Ltd | Financial services | 2026 |
| Spatz Film Ltd | Information & communication | 2017 |
| SPC Property Holdings Ltd | Real estate | 2024 |
| SPE Chemicals Co., Ltd | Wholesale & retail | 2014 |
| Spear Cars Limited | Wholesale & retail | 2018 |
| Spear Garage and Repairs Ltd | Wholesale & retail | 2023 |
| Spear Garage Limited | Wholesale & retail | 2020 |
| Spear Insights Consulting Ltd | Professional & scientific | 2025 |
| Spear Property Limited | Real estate | 2026 |
| Spearhead Technologies Limited | Wholesale & retail | 2024 |
| Specialised Buildfix Services Ltd | Construction | 2013 |