| Sherwood Court Management (Stafford) Limited | Households | 2014 |
| Shimla Palace Staffordshire Limited | Hospitality | 2019 |
| Shine Dental Practice Limited | Health & social care | 2010 |
| Shineair Ceramics Limited | Wholesale & retail | 2025 |
| Shini Productions Ltd | Information & communication | 2023 |
| Shining Fias Ltd | Manufacturing | 2024 |
| Shining Star Trading Co., Ltd | Wholesale & retail | 2024 |
| Ship and Star Ltd | Arts & recreation | 2023 |
| Shipax Logistics Limited | Wholesale & retail | 2024 |
| Shire Branding Ltd | Manufacturing | 2023 |
| Shire Construction (Midlands) Limited | Construction | 2023 |
| Shire FM Ltd | Administrative & support | 2026 |
| Shivarco Limited | Wholesale & retail | 2024 |
| Shoby Logistic Ltd | Transport & logistics | 2018 |
| Shoes by MM Ltd | Wholesale & retail | 2023 |
| Shoestring Sound Studio Limited | Information & communication | 2025 |
| Shokz Health Limited | Wholesale & retail | 2025 |
| Shopi Ltd | Wholesale & retail | 2021 |
| Short Supply Limited | Wholesale & retail | 2009 |
| Shortcode Ltd | Information & communication | 2022 |
| Shortwood Dairy Limited | Agriculture & fishing | 2004 |
| Shout Local Media Ltd | Information & communication | 2015 |
| Show Z (UK) Co., Limited | Wholesale & retail | 2022 |
| Shrapnel UK Ltd | Other services | 2023 |
| Shred Nest Limited | Wholesale & retail | 2025 |
| Shree Mandava Limited | Real estate | 2023 |
| Shropshire and Staffordshire Kitchens Limited | Construction | 2015 |
| SHU ER MAN Group Ltd | Manufacturing | 2024 |
| Shuma Balti Ltd | Hospitality | 2020 |
| Shunfengyang Trading Limited | Wholesale & retail | 2025 |
| Shuqun Ltd | Professional & scientific | 2021 |
| Shushions Barns Management Company Limited | Households | 2005 |
| Shutter & Co. Photography Ltd | Professional & scientific | 2019 |
| SI Accounting Services Limited | Other services | 2018 |
| Sidler Dynamic Engineering (UK) Ltd | Mining & quarrying | 2002 |
| Siebec UK Limited | Wholesale & retail | 1996 |
| Sienna Tanning and Beauty Limited | Other services | 2004 |
| Sigma Interiors Ltd | Construction | 2025 |
| Sigma Stones Ltd | Information & communication | 2019 |
| Sigmatech Consulting Ltd | Information & communication | 2023 |
| Sigmundr Limited | Construction | 2016 |
| Signposts (Stafford) Ltd | Administrative & support | 2006 |
| Sihui Hongbaihua Clothing Co., Ltd | Wholesale & retail | 2025 |
| Sijialet Limited | Wholesale & retail | 2024 |
| Silence JUN Ltd | Wholesale & retail | 2021 |
| Silk Road Business Management Co Ltd | Wholesale & retail | 2020 |
| Silk Road Retail Ltd | Wholesale & retail | 2025 |
| Silmar Travel Ltd | Transport & logistics | 2020 |
| Silver Dream Tours Limited | | 1981 |
| Silverfox Trading Company Limited | Wholesale & retail | 2020 |
| Simcla Romanian Shop Limited | Wholesale & retail | 2019 |
| Simcox CX Limited | Professional & scientific | 2025 |
| Simmons Estates Limited | Real estate | 2017 |
| Simpara Badara Trading Company Ltd | Wholesale & retail | 2025 |
| Simple Energy Matters Ltd | Professional & scientific | 2023 |
| Simple Steps Tech Support Ltd | Information & communication | 2026 |
| Simplex Solutions Limited | Information & communication | 2000 |
| Simply Bilash Limited | Hospitality | 2013 |
| Simply Mortgages and Protection Ltd | Financial services | 2019 |
| Simsin Services Limited | Administrative & support | 2025 |
| Simsin Trading Limited | Wholesale & retail | 2025 |
| Simulator Stafford Ltd | Arts & recreation | 2026 |
| Simwood Estates Limited | Administrative & support | 2017 |
| Simwood Trading Limited | Construction | 2017 |
| Singh & Kaur Property Management Ltd | Real estate | 2025 |
| Singletoned Limited | Information & communication | 2014 |
| Sinister Sisterhood Ltd | Wholesale & retail | 2026 |
| Sino-British (International) Intelligent Technology Group Company Limited | Manufacturing | 2023 |
| Sinodeal International Limited | Extraterritorial | 2012 |
| Sinopharm Weiqida Pharmaceutical Ltd | Manufacturing | 2023 |
| Sinovia E-Mart Ltd | Wholesale & retail | 2024 |
| Sinutek Limited | Professional & scientific | 2024 |
| Siraj Holdings Ltd | Real estate | 2026 |
| Sirav Connect Ltd | Information & communication | 2025 |
| Siren Stories Ltd | Professional & scientific | 2018 |
| Sirisha Housing Limited | Real estate | 2023 |
| Sirisha Limited | Health & social care | 2020 |
| Site Digital Limited | Construction | 2026 |
| SIX Ashes (Bridgnorth) Ltd | Hospitality | 2016 |
| Siyang DA Trade Ltd | Manufacturing | 2024 |
| SJ Learning Project Management Limited | Professional & scientific | 2015 |
| SJC Vehicle Solutions Limited | Wholesale & retail | 2026 |
| SJH Offshore Services Ltd | Construction | 2023 |
| SJJ Holdings Limited | Real estate | 2021 |
| Sjna Services Ltd | Information & communication | 2024 |
| Sjrconsulting Ltd | Information & communication | 2026 |
| SK Assessments Ltd | Health & social care | 2022 |
| SK Eccleshall Limited | Hospitality | 2024 |
| SK Environmental Ltd | Real estate | 2017 |
| SK Health Reports Ltd | Health & social care | 2020 |
| Skilton Surgical Limited | Health & social care | 2024 |
| Skin Health LAB Ltd | Wholesale & retail | 2025 |
| Skrh Property Ltd | Real estate | 2025 |
| Skybound Technologies Ltd | Wholesale & retail | 2025 |
| Skyla Enterprises Ltd | Administrative & support | 2019 |
| Skyllz Concepts Ltd | Health & social care | 2024 |
| Skyreach Access Solutions Limited | Administrative & support | 2003 |
| Skytherion Ltd | Wholesale & retail | 2025 |
| Skyward Marine Limited | Professional & scientific | 2016 |
| Skywing Technologies Ltd | Information & communication | 2024 |