| Saxon House Group Limited | Real estate | 2026 |
| SB2 Decorating Limited | Construction | 2017 |
| SBL Building Limited | Construction | 2019 |
| SBV Computing Limited | Information & communication | 2004 |
| Scaftech (Wolverhampton) Limited | Construction | 2003 |
| Schiro Ltd | Hospitality | 2022 |
| Schott Fibre Optics (UK) Limited | Professional & scientific | 1977 |
| Schweitzer Engineering Laboratories UK, Limited | Wholesale & retail | 2018 |
| Scimitar Media Ltd | Information & communication | 2018 |
| Scissors Franchise Company Ltd. | Other services | 2008 |
| Scott James Gater Limited | Transport & logistics | 2023 |
| Scservices(Milcot) Ltd | Transport & logistics | 2024 |
| SD Finserv Limited | Professional & scientific | 2024 |
| SDA and More Limited | Wholesale & retail | 2026 |
| SDC Management Solutions Ltd | Construction | 2025 |
| SDH Software Limited | Information & communication | 2011 |
| SDV Groundworks Ltd | Construction | 2024 |
| Sdvine Plant Hire Ltd | Administrative & support | 2021 |
| SE Business Finance Limited | Financial services | 2026 |
| Seabridge Developments Holdings Limited | Financial services | 2019 |
| Seabridge Developments Limited | Construction | 2013 |
| Seadona Machinery Industry Co., Limited | Wholesale & retail | 2019 |
| Sealstone Exterior Services Ltd | Administrative & support | 2024 |
| Sean Foster Limited | Wholesale & retail | 2017 |
| Seaohaut International Technology Limited | Extraterritorial | 2019 |
| Seashell Property Management Services Limited | Real estate | 2024 |
| Seasons Massage Ltd | Health & social care | 2025 |
| Sebakwe Holdings Limited | Financial services | 2021 |
| Secured Vehicle Solutions Ltd | Wholesale & retail | 2021 |
| Sedberg Ltd | Manufacturing | 2022 |
| Seica Limited | Professional & scientific | 2025 |
| SEL Group Ltd | Professional & scientific | 2017 |
| Select Keys Properties Ltd | Real estate | 2026 |
| Selfcare Psychology Limited | Administrative & support | 2017 |
| SEM Capital Ltd | Financial services | 2024 |
| SEM FM Ltd | Financial services | 2025 |
| Semantics 21 Ltd | Information & communication | 2015 |
| Semil Ltd | Manufacturing | 2012 |
| Semwa Services Ltd | Administrative & support | 2025 |
| Senboshi Consultants Limited | Extraterritorial | 2021 |
| Senior Green Limited | Manufacturing | 2006 |
| Senomed Limited | Health & social care | 2023 |
| Sensational Memorabilia Ltd | Manufacturing | 2024 |
| Sentinel Cleaning Services Ltd | Administrative & support | 2026 |
| Sentinel Events Limited | Construction | 2010 |
| Seraphina International Trade Co., Ltd | Wholesale & retail | 2025 |
| SES Building Repairs & Disaster Management Ltd | Real estate | 1998 |
| Sevec Ltd | Construction | 2017 |
| Severn Electrical Solutions Limited | Construction | 2015 |
| Sevlow Services Limited | Manufacturing | 2023 |
| Seylac Limited | Professional & scientific | 2019 |
| SFF Gym C.I.C. | Education | 2019 |
| SFG Logistic Ltd | Transport & logistics | 2018 |
| Sfkhan Ltd | Health & social care | 2026 |
| SGK Properties Ltd | Real estate | 2019 |
| Sgyhbzgygq Limited | Information & communication | 2021 |
| SH Complete Energy Services Ltd | Construction | 2025 |
| SH Window Cleaning Limited | Administrative & support | 2015 |
| SHA KA REE Ltd | Hospitality | 2024 |
| Shakespeare Fitting OUT Ltd | Construction | 2017 |
| Shallowford Mews Maintenance Limited | Households | 1990 |
| Shamsian Limited | Wholesale & retail | 2014 |
| Shandon GAS Services Ltd | Professional & scientific | 2003 |
| Shandong Hongsheng Rubber Technology Co., Ltd | Extraterritorial | 2016 |
| Shandong Qidu Pharmaceutical Co., Ltd | Manufacturing | 2025 |
| Shandong SAN Yuan Metal Co., Ltd | Manufacturing | 2022 |
| Shandong Vette International Trade Co., Ltd. | Extraterritorial | 2022 |
| Shandong Yide Machinery Co., Ltd | Wholesale & retail | 2025 |
| Shane Brown Solutions Ltd | Transport & logistics | 2026 |
| Shanghai Pinxing Explosion-Proof Motor Co., Ltd | Extraterritorial | 2015 |
| Shanghai Raggie Power Co., Ltd | Extraterritorial | 2020 |
| Shangli Aggregators Co., Limited | Transport & logistics | 2024 |
| Shanrye Farm Friends CIC | Education | 2025 |
| Shaoxing East Asia IMP. and EXP. Co., Ltd | Extraterritorial | 2014 |
| Sharant Limited | Wholesale & retail | 2004 |
| Sharkey Finishing Services Ltd | Manufacturing | 2026 |
| Shati Import&Export Co., Ltd | Extraterritorial | 2021 |
| Shaw Medical Services Limited | Health & social care | 2014 |
| Shaw Property Investment and Management Ltd | Real estate | 2025 |
| Shaw's Timber Solutions Limited | Construction | 2011 |
| Shawman Equipment Limited | Wholesale & retail | 2022 |
| Shawman Plant & Equipment Services Limited | Wholesale & retail | 2020 |
| Shaws K9 Supplies Ltd | Wholesale & retail | 2025 |
| Shazac Property Ltd | Real estate | 2020 |
| Sheila Anne Group Limited | Hospitality | 2018 |
| Shelby HOG Roast Co. Ltd | Hospitality | 2022 |
| Shelmore Farm Limited | Agriculture & fishing | 2019 |
| Shenglong Power Technology Co., Ltd | Manufacturing | 2022 |
| Shenzhen Longshenghui Import& Export Co., Ltd | Wholesale & retail | 2023 |
| Shenzhen Luxrgb Technology Co., Ltd | Extraterritorial | 2013 |
| Shenzhen Yichuang Technology Ltd | Professional & scientific | 2024 |
| Shepard UK Ltd | Information & communication | 2024 |
| Shepco Limited | Administrative & support | 2002 |
| Sheppards Solicitors Ltd | Professional & scientific | 2005 |
| Sheps Electrics Limited | Construction | 2025 |
| Sherbrook Ltd | Real estate | 2024 |
| Shereen Brizan ODP Ltd | Health & social care | 2022 |
| Sherwin Builders Holdings Limited | Financial services | 2020 |
| Sherwin Builders Investments Limited | Real estate | 2020 |
| Sherwins Builders Limited | Construction | 2006 |