| S & P Construction Gnosall Ltd | Construction | 2025 |
| S & R (Brenna) Limited | Other services | 2025 |
| S & S Garages Limited | Wholesale & retail | 2025 |
| S & S Grab Hire & Aggregates Limited | Water & waste | 2020 |
| S & S Multiplant Hire Ltd | Manufacturing | 2017 |
| S a Entertainment (Maidstone) Ltd | Hospitality | 2020 |
| S a S and Company Private Ltd | Health & social care | 2017 |
| S Coxon Electrical Ltd | Construction | 2025 |
| S E Property & Interior Systems Ltd | Construction | 2022 |
| S Hollins Plumbing and Heating Limited | Construction | 2003 |
| S M K Haulage Limited | Transport & logistics | 2006 |
| S T Douglas Transport Limited | Transport & logistics | 2003 |
| S Zoev Convenience Store Ltd | Wholesale & retail | 2016 |
| S&A and Partners Ltd | Wholesale & retail | 2025 |
| S. J. Gould Construction Limited | Construction | 2017 |
| S. Nakash Medical Limited | Health & social care | 2010 |
| S. Phillips Consultancy Ltd | Information & communication | 2026 |
| S.Earll Limited | Professional & scientific | 2010 |
| S4J Limited | Construction | 2011 |
| Sa&E Peel Ltd | Wholesale & retail | 2023 |
| Saad International Business Trading Limited | Wholesale & retail | 2025 |
| SAB Motorcycle Storage Limited | Wholesale & retail | 1998 |
| Sabnetcomms Ltd | Information & communication | 2018 |
| Sabre Property Investments Ltd | Construction | 2019 |
| Sabrengrove Limited | Construction | 1970 |
| Sacko Import and Export Co., Ltd | Wholesale & retail | 2024 |
| Sacred Pyramid Ltd | Wholesale & retail | 2025 |
| Saddington-Spring Autism, Adhd & Dyslexia Services Ltd | Health & social care | 2025 |
| Saddington-Spring Counselling & Psychology Services Limited | Health & social care | 2018 |
| Safe Haven AID C.I.C. | Professional & scientific | 2026 |
| Safeguarded Training Ltd | Professional & scientific | 2019 |
| Safer Recruitment Limited | Administrative & support | 2009 |
| Safety Forward Limited | Professional & scientific | 2014 |
| Safeweld Fabrications Limited | Manufacturing | 2021 |
| Safineia Ltd | Professional & scientific | 2020 |
| Safp Trading Limited | Financial services | 2024 |
| Safsaj Limited | Wholesale & retail | 2026 |
| Sahara One Limited | Wholesale & retail | 2025 |
| Sahara Valley Ltd | Wholesale & retail | 2011 |
| Saijie Technology Co., Limited | Wholesale & retail | 2025 |
| Sailor Intl Development Co., Ltd. | Wholesale & retail | 2025 |
| Saladmaster UK Limited | Wholesale & retail | 2015 |
| Salehi Brothers Limited | Real estate | 2017 |
| Sales Meddic Ltd | Professional & scientific | 2024 |
| Salix Entertainments Limited | Hospitality | 2016 |
| Sallong Limited | Health & social care | 2010 |
| Sally's Little Monsters Limited | Health & social care | 2012 |
| Salt Heath Estate Ltd | Real estate | 2022 |
| Salt N Pepper Chilli Box Ltd | Hospitality | 2025 |
| Salt White Limited | Professional & scientific | 2016 |
| Salts Holdings Limited | Real estate | 2018 |
| SAM Grove Trading Ltd | Wholesale & retail | 2024 |
| Sam's Electrical Services Limited | Construction | 2003 |
| Sama International Trading Co., Ltd | Wholesale & retail | 2025 |
| Samagra Limited | Information & communication | 2023 |
| Samantha Williams Estate Agents Ltd | Real estate | 2021 |
| Sambuck Limited | Information & communication | 2003 |
| Same VET Ltd | Professional & scientific | 2022 |
| Samgen UK Ltd | Professional & scientific | 2020 |
| Samhn IMP and EXP Co., Limited | Wholesale & retail | 2025 |
| Samma Panidana Limited | Other services | 2023 |
| SAN Feng Co., Limited | Extraterritorial | 2013 |
| Sana Halidou Trading Co., Ltd | Wholesale & retail | 2024 |
| Sanctuary Aesthetics Limited | Other services | 2019 |
| Sandon Mews Freehold Limited | Households | 2018 |
| Sandon Mews Management Company Limited | Households | 1983 |
| Sandon Properties Ltd | Real estate | 2025 |
| Sandstone Finance Ltd | Professional & scientific | 2026 |
| Sandwell Glazing Limited | Construction | 2002 |
| Sandy & Co Investments Ltd | Real estate | 2015 |
| Sandy Joinery Limited | Manufacturing | 2016 |
| Sandytots Limited | Health & social care | 2013 |
| Sangria Sips Limited | Hospitality | 2024 |
| Sanhow Consulting Ltd | Administrative & support | 2014 |
| Sanovo Ltd | Professional & scientific | 2018 |
| Sanpella Limited | Manufacturing | 2021 |
| Sans Assets Ltd | Real estate | 2022 |
| Sansan Holding Co., Ltd | Wholesale & retail | 2023 |
| Sansom Farming Ltd | Agriculture & fishing | 2024 |
| Sansom Group Ltd | Financial services | 2024 |
| Sanya Sidi Trading Co., Ltd | Wholesale & retail | 2025 |
| Sapphire Plumbing and Heating (Midlands) Limited | Construction | 2021 |
| Sapphire Property Services (Midlands) Limited | Construction | 2018 |
| Sara Cooper Photography Ltd | Professional & scientific | 2020 |
| Saracen Exports (UK) Ltd | Wholesale & retail | 2004 |
| Sarah Mcalpine Limited | Other services | 2014 |
| Saran International Trading Company Limited | Wholesale & retail | 2026 |
| Sarian Ltd | Administrative & support | 2016 |
| Saromuka Properties Ltd | Real estate | 2024 |
| Sarwin LA Dondo Ltd | Manufacturing | 2024 |
| SAS Advice Ltd | Health & social care | 2017 |
| Sator Fire & Security Limited | Other services | 2006 |
| Satori Tattoo Ltd | Other services | 2020 |
| Saturn Electrical Systems Limited | Construction | 2025 |
| Saunders Investments Limited | Real estate | 2021 |
| Savetik Ltd | Information & communication | 2023 |
| Savi Boutique Ltd | Manufacturing | 2025 |
| Savipower Ltd | Manufacturing | 2025 |
| Sawn Healthcare Services Limited | Health & social care | 2025 |
| Saxon Barons Limited | Wholesale & retail | 2022 |