| SHOP4UBR Ltd | Other services | 2024 |
| Shoto Ltd | Construction | 2018 |
| Show LEE the Money Ltd | Health & social care | 2014 |
| Shriman Developments Ltd | Real estate | 2020 |
| Sidcup Healthcare Ltd | Wholesale & retail | 2017 |
| Side by Side Properties Limited | Real estate | 2026 |
| Sidla Transport Ltd. | Transport & logistics | 2015 |
| SIF Medical Ltd | Health & social care | 2023 |
| Signature Personnel Ltd | Administrative & support | 2022 |
| Signature Scones Ltd | Hospitality | 2026 |
| Signature Support Solutions Ltd | Health & social care | 2024 |
| Signing Solutions CIC | Professional & scientific | 2019 |
| Simon Magee Ltd | Transport & logistics | 2019 |
| Simon Ross Decor Limited | Construction | 2016 |
| Simphil Limited | Transport & logistics | 2003 |
| Simply GUT Health Ltd | Health & social care | 2025 |
| Simply LET ME Limited | Transport & logistics | 2019 |
| Simply Media Manchester Limited | Professional & scientific | 2017 |
| Simpson Property Management Limited | Real estate | 2017 |
| Simtel Ltd | Information & communication | 2020 |
| Sinclair Electrical Limited | Construction | 2017 |
| Sinclair Orthodontics Limited | Health & social care | 2002 |
| Singletonpub Ltd | Hospitality | 2025 |
| Sink Ltd | Manufacturing | 2004 |
| Sinoway International Limited | Wholesale & retail | 2002 |
| Siqs Solutions Ltd | Construction | 2023 |
| SIR Angel Ltd | Wholesale & retail | 2026 |
| Sirikonda Properties Ltd | Real estate | 2012 |
| SIS Fashion UK Ltd | Wholesale & retail | 2022 |
| Sisco Construction Ltd | Construction | 2020 |
| Sister Mabel Limited | Wholesale & retail | 2024 |
| Sitecote Holdings Limited | Financial services | 2018 |
| Sitecote Limited | Manufacturing | 2009 |
| Sitecote Solutions Ltd | Manufacturing | 2017 |
| Sitecote Supplies Limited | Wholesale & retail | 2018 |
| SJ Crawford Piping Services Ltd | Manufacturing | 2021 |
| Sj&Co Property Ltd | Real estate | 2026 |
| SJC Consultancy (North West) Limited | Education | 2013 |
| Sjglr Properties Limited | Real estate | 2022 |
| Sjls Properties Limited | Real estate | 2021 |
| SJT Services Ltd | Construction | 2003 |
| SJZ Limited | Real estate | 2009 |
| SK Barber ST Helens Ltd | Other services | 2025 |
| SK Barber VIP Ltd | Other services | 2026 |
| SK Plumbing & Heating Services Limited | Construction | 2023 |
| Sk!Ntology Ltd | Health & social care | 2017 |
| SKA Healthcare Limited | Wholesale & retail | 2019 |
| Skelton Bayley Associates Ltd | Professional & scientific | 2007 |
| Sken Estates Limited | Real estate | 2024 |
| Sken Limited | Health & social care | 2023 |
| Skin Klinik Ltd | Health & social care | 2025 |
| Skinology by SA Aesthetics Ltd | Other services | 2020 |
| Skl-Tn Ltd | Wholesale & retail | 2025 |
| Skyepay Limited | Administrative & support | 2026 |
| Skyners Limited | Construction | 2003 |
| Skyward-Vision Limited | Manufacturing | 2019 |
| SL FIX Limited | Administrative & support | 2023 |
| Slate and Bloom Developments Ltd | Real estate | 2026 |
| Slawek Ltd | Transport & logistics | 2016 |
| SLC Techcon Limited | Information & communication | 2014 |
| Sleepwalker Films Limited | Information & communication | 2018 |
| Slhc Ltd | Professional & scientific | 2018 |
| Slyne Healthcare Limited | Wholesale & retail | 2013 |
| SM Roofing and Cladding Limited | Construction | 2019 |
| SM Usman Ltd | Hospitality | 2026 |
| Smaa Limited | Health & social care | 2020 |
| Smagennissecurity Limited | Administrative & support | 2022 |
| Smart Airways Limited | Transport & logistics | 2022 |
| Smart Choice Builders Limited | Construction | 2019 |
| Smart Energy Consultancy Limited | Professional & scientific | 2019 |
| Smart Heating With SAM Limited | Construction | 2017 |
| Smart Holiday Haven Limited | Administrative & support | 2025 |
| Smart Legal Consulting Ltd | Professional & scientific | 2024 |
| Smart Living Developments Ltd | Construction | 2023 |
| Smart Stairs Ltd | Construction | 2024 |
| Smartclicker Automations Ltd | Information & communication | 2026 |
| Smarter Greener Solutions Limited | Construction | 2023 |
| Smashies ST Helen Ltd | Hospitality | 2025 |
| SME Construction Ltd | Construction | 2017 |
| Smile Barber Co Ltd | Other services | 2026 |
| Smile BARBER1 Ltd | Other services | 2025 |
| Smile&Weave Hair and Beauty Limited | Other services | 2024 |
| Smillie Consulting Ltd | Professional & scientific | 2025 |
| Smith & Co Driveways Ltd | Administrative & support | 2025 |
| Smith & Garratt Health & Beauty Ltd | Wholesale & retail | 2021 |
| Smith Contract Services Ltd | Administrative & support | 2018 |
| Smiths Logistic Services Ltd | Transport & logistics | 2025 |
| Smith’S Sandwich Bar Ltd | Hospitality | 2025 |
| Smoothfin Plastering Ltd | Construction | 2025 |
| SMP Maintenance Ltd | Construction | 2024 |
| SMP Property Letting and Management Ltd | Real estate | 2022 |
| Snapped UP Ltd | Administrative & support | 2019 |
| Snappy Sloth Media Ltd | Professional & scientific | 2025 |
| Snorezforpawz Ltd | Other services | 2025 |
| Snowdog Ltd | Professional & scientific | 2007 |
| SO Peachy Treatments and Training Academy Limited | Other services | 2020 |
| Social Mama Ltd | Professional & scientific | 2025 |
| Social Sisters Ltd | Health & social care | 2026 |
| SOL Noche Group Ltd | Hospitality | 2026 |
| Sole Therapies Foot Clinics Ltd | Health & social care | 2025 |