| Salvus Support Ltd | Health & social care | 2023 |
| Samazu Limited | Wholesale & retail | 2025 |
| Samdeb Limited | Transport & logistics | 2025 |
| Samson Contracting Ltd | Construction | 2021 |
| Samurai School of Martial Arts Limited | Arts & recreation | 2003 |
| SAN Julian Hospitality Services Ltd | Hospitality | 2023 |
| Sancar Enterprises Ltd | Wholesale & retail | 2015 |
| Sanctus Gym Ltd | Arts & recreation | 2024 |
| Sangtawan Spa & Thai Massage Ltd | Other services | 2025 |
| Sanrita Consultancy Ltd | Professional & scientific | 2024 |
| Santawne Limited | Construction | 1976 |
| Santos Pizza Ltd | Hospitality | 2026 |
| Sapphire Rentals Ltd | Real estate | 2019 |
| Sapphires Venue and Balloon Decor Ltd | Other services | 2016 |
| Sara Heeley Limited | Hospitality | 2018 |
| Sarah Martin Consultancy Limited | Education | 2011 |
| SAS Facades Ltd | Construction | 2024 |
| SAS Total Services Limited | Water & waste | 2012 |
| Savage Steelworx Ltd | Manufacturing | 2022 |
| Savoirproducts Ltd | Wholesale & retail | 2024 |
| Saxon Hair Limited | Other services | 2011 |
| SB Coaching and Consultancy Ltd | Education | 2022 |
| SBP Investments Limited | Other services | 2014 |
| Sbrtelecom Ltd | Information & communication | 2023 |
| SBS Capital Ltd | Financial services | 2025 |
| SC Construkt Ltd | Construction | 2022 |
| Scarjack Limited | Real estate | 2023 |
| SCD Auto Electrical Ltd | Professional & scientific | 2017 |
| Scent-D Ltd | Manufacturing | 2026 |
| Scents From Heaven by Madison Ltd | Wholesale & retail | 2022 |
| Scholars Way (Windle) (Two) Management Company Limited | Households | 2009 |
| School of Carpentry Ltd | Education | 2023 |
| Schooner Wines Limited | Wholesale & retail | 2010 |
| Scott Home Solutions Ltd | Wholesale & retail | 2022 |
| Scott's Deli & Catering Limited | Hospitality | 2017 |
| Scran & Shakes Ltd | Hospitality | 2024 |
| Scrubber Dryer and Sweeper Hire Limited | Manufacturing | 2024 |
| SD Investments (NW) Limited | Real estate | 2017 |
| SDH Engineering Limited | Professional & scientific | 2017 |
| SDH Joinery & Building Ltd | Construction | 2024 |
| SDH Profiles Ltd | Professional & scientific | 2019 |
| SDL Property Services Ltd | Real estate | 2026 |
| SDR Stump Grinding Ltd | Administrative & support | 2025 |
| Seak Developments Ltd | Construction | 2021 |
| Seapack Homes Ltd | Real estate | 2020 |
| Secronyx Limited | Information & communication | 2023 |
| Sekvoja Capital Ltd | Real estate | 2022 |
| Selby Pharmacy Limited | Wholesale & retail | 2010 |
| Selby Road Healthcare Ltd | Wholesale & retail | 2025 |
| Selective Management Limited | Professional & scientific | 2023 |
| Self Love Academy Limited | Education | 2024 |
| Self Love Salon Limited | Other services | 2024 |
| Selja Properties LLP | | 2023 |
| Selphie Studios Ltd | Professional & scientific | 2026 |
| Sephton Project Management Specialists Ltd | Professional & scientific | 2023 |
| Serene Workspaces Ltd | Real estate | 2023 |
| Serenity One Hair Ltd | Other services | 2024 |
| Sergiu Pavaloae Ltd | Transport & logistics | 2017 |
| Seriously Naughty Limited | Wholesale & retail | 2021 |
| Services 88 Ltd | Transport & logistics | 2020 |
| Servik&Food Limited | Wholesale & retail | 2024 |
| Sevro Limited | Professional & scientific | 2025 |
| Sexton Avenue Community Allotment Garden C.I.C. | Health & social care | 2020 |
| Seymour Construction Ltd. | Construction | 2008 |
| SFG Building Services Ltd | Construction | 2022 |
| Sfnenterprise Ltd | Transport & logistics | 2018 |
| SG17 Consultancy & Advisory Services Limited | Professional & scientific | 2024 |
| Shalom Group Ltd | Transport & logistics | 2018 |
| SHANDONS1 Ltd | Hospitality | 2025 |
| Shap Ltd | Hospitality | 1985 |
| Sharen Consultants Ltd | Health & social care | 2013 |
| Sharief Building Limited | Construction | 2020 |
| Sharief Farm Ltd | Agriculture & fishing | 2021 |
| Sharief Group 2 Limited | Financial services | 2023 |
| Sharief Healthcare 2 Limited | Wholesale & retail | 2023 |
| Sharief Holding 2 Limited | Financial services | 2019 |
| Sharief Holding Limited | Wholesale & retail | 2016 |
| Sharief Ltd | Professional & scientific | 2009 |
| Sharief Oakfield Shares 2 Limited | Financial services | 2023 |
| Sharief Oakfield Shares Ltd | Other services | 2019 |
| Sharief Pharma Limited | Wholesale & retail | 2016 |
| Sharief Properties 2 Limited | Real estate | 2020 |
| Sharief Properties Limited | Real estate | 2016 |
| Shark Crewe Limited | Hospitality | 2018 |
| Shattered Sheep Productions Limited | Information & communication | 2019 |
| Shaun Pearce Limited | Construction | 2019 |
| Shaun Rooney Engineering Services Ltd | Manufacturing | 2022 |
| Shaweng Ltd | Professional & scientific | 2022 |
| Shawki Ltd | Health & social care | 2023 |
| Sheff Pharma Ltd | Wholesale & retail | 2022 |
| Shepherd & Hole Proprieties Ltd | Real estate | 2025 |
| Sherdley Builders Limited | Construction | 2015 |
| Shine Theatre Academy Ltd | Education | 2025 |
| Shinehomecleaningltd Ltd | Administrative & support | 2025 |
| SHINEY9 Ltd | Hospitality | 2017 |
| Shiny Show Cleaning Ltd | Administrative & support | 2024 |
| Shiplec UK Ltd | Extraterritorial | 2021 |
| Shipton Property Group Limited | Real estate | 2025 |
| SHIRLEYS1955 Ltd | Hospitality | 2026 |
| Shmh Ltd | Hospitality | 2019 |