| RMB World Ltd | Transport & logistics | 2020 |
| RMD Motors Limited | Wholesale & retail | 2025 |
| RMT Machine Tools Limited | Extraterritorial | 2026 |
| RMW Hire Ltd | Administrative & support | 2025 |
| RN Building Developments Ltd | Construction | 2024 |
| Robins Lane Barbers & Beauty Ltd | Other services | 2024 |
| Rochdale Development Company Limited | Financial services | 1988 |
| Rochdale Power Ltd | Construction | 2020 |
| Rock 'N' Pole Ltd | Arts & recreation | 2019 |
| Rock Kidz Ltd | Arts & recreation | 2016 |
| Rocket (Liverpool) Ltd | Real estate | 2016 |
| Rocket Embroidery Limited | Manufacturing | 2011 |
| Rockets Community Club CIC | Education | 2025 |
| Rodeo Pilates Limited | Arts & recreation | 2025 |
| RODINS47 Ltd | Transport & logistics | 2024 |
| Rogue Products Limited | Wholesale & retail | 2025 |
| Rokserv Hire (NW) Limited | Administrative & support | 2016 |
| Rokserv Limited | Administrative & support | 2009 |
| Roll Model Group Ltd | Manufacturing | 2021 |
| Roll Model Youth & Community Development CIC | Education | 2017 |
| Roller Shutter Services Ltd | Manufacturing | 2006 |
| Romcon Investments Ltd | Professional & scientific | 2017 |
| Ronan Rapid Travel Limited | Transport & logistics | 2025 |
| Rongwan Limited | Hospitality | 2024 |
| Ronova Property Limited | Real estate | 2026 |
| Roofsmart Systems Ltd | Construction | 2017 |
| Roscoe MOT Station Ltd | Wholesale & retail | 2024 |
| Rosebuds Day Nursery Ltd | Health & social care | 2019 |
| Rosemary Homes C.I.C. | Health & social care | 2020 |
| Rosie Robinson Consultancy Ltd | Professional & scientific | 2023 |
| Rosie’S Re-Treat Dog Walking & Daycare Ltd | Agriculture & fishing | 2024 |
| Rossi Socials Limited | Professional & scientific | 2026 |
| Rowyn Ltd | Professional & scientific | 2014 |
| ROY Mini Market ST Helens Limited | Wholesale & retail | 2025 |
| Royale Building Contractors Ltd | Construction | 2022 |
| Royale Landscape Limited | Administrative & support | 2022 |
| RPD Plumbing and Heating Limited | Construction | 2017 |
| Rrhotel Ltd | Hospitality | 2025 |
| RRJ North West Ltd | Wholesale & retail | 2025 |
| RS Scaffolding Solutions Ltd | Construction | 2025 |
| Rs&A Education and Consultancy Ltd | Professional & scientific | 2024 |
| RST Drying & Plastering Ltd | Construction | 2026 |
| RT Roofing Ltd | Construction | 2022 |
| Ruan Thai Group Ltd | Hospitality | 2015 |
| Ruby N Ralphies Ltd | Other services | 2022 |
| Rummage Around Ltd | Wholesale & retail | 2024 |
| Ruskin Properties (ST Helens) Ltd | Administrative & support | 2014 |
| Ruskinvest Limited | Arts & recreation | 2011 |
| Rusnac's Services Ltd | Transport & logistics | 2018 |
| Rutterstone Limited | Administrative & support | 2024 |
| RV Holdings (NW) Limited | Financial services | 2014 |
| RWL Holdings Limited | Real estate | 2025 |
| Ryacon Ltd | Manufacturing | 2024 |
| Ryan and Sumner Ltd | Other services | 2009 |
| Ryder Property Holdings Ltd | Real estate | 2019 |
| S & K Design Ltd | Professional & scientific | 2019 |
| S & L Wilson Limited | Health & social care | 2010 |
| S & N Electrical Services Ltd | Construction | 2022 |
| S Cunliffe & Associates Ltd | Health & social care | 2017 |
| S F Logistics Ltd | Administrative & support | 2014 |
| S H 888 Chippy Ltd | Hospitality | 2021 |
| S L Ceramics Ltd | Construction | 2010 |
| S M Medics Ltd | Real estate | 2021 |
| S P Hughes & Sons Limited | Administrative & support | 2024 |
| S Parr Electrical Limited | Construction | 2024 |
| S Sheppard Distribution Ltd | Transport & logistics | 2010 |
| S W Building Contractors Limited | Construction | 2004 |
| S W Hydro Limited | Energy | 2011 |
| S&G Mobile Mechanics Ltd | Wholesale & retail | 2023 |
| S&M Plastering LLP | | 2004 |
| S.Cavaliere Limited | Information & communication | 2025 |
| S.J. Painters Limited | Construction | 2001 |
| S.J.Stuart Groundworks & Plant Hire Ltd | Agriculture & fishing | 2020 |
| S.L.H Property Management Experts Ltd | Real estate | 2019 |
| S.S.C Physiotherapy Ltd | Other services | 2023 |
| S7OPA Logistics Limited | Transport & logistics | 2022 |
| Saeed Limited | Wholesale & retail | 2010 |
| Safe Condition Ltd | Professional & scientific | 2020 |
| Safe Practice Ltd | Construction | 2026 |
| Safeguard Scaffolding North West Limited | Construction | 2018 |
| Saffil 2011 Limited | Professional & scientific | 2011 |
| Saffil Limited | Manufacturing | 1998 |
| Safi's ST Helens Ltd | Hospitality | 2024 |
| Sahiwal Enterprise Ltd | Wholesale & retail | 2025 |
| Saints Care Ltd | Health & social care | 2023 |
| Saints Community Development Foundation Limited | Arts & recreation | 2016 |
| Saints Halal Supermarket Limited | Wholesale & retail | 2025 |
| Saints Properties Ltd | Real estate | 2022 |
| Saints Property Clearance Ltd | Transport & logistics | 2010 |
| Saker Aviation Services Limited | Manufacturing | 2017 |
| Sakis Transport Ltd | Transport & logistics | 2019 |
| Salem MCR Ltd | Hospitality | 2019 |
| Sales Division Limited | Financial services | 2017 |
| Salford Pharma Limited | Wholesale & retail | 2023 |
| Salman Healthcare Limited | Wholesale & retail | 2011 |
| Salon GBX Limited | Other services | 2022 |
| Salon Growth Partner Ltd | Wholesale & retail | 2025 |
| Salus (U.K.) Limited | Wholesale & retail | 1981 |
| Salus Pharmacy Limited | Wholesale & retail | 2011 |
| Salustec Ltd | Other services | 2018 |