| Southport Funeralcare Ltd | Other services | 2021 |
| Southport Furniture Collective Limited | Wholesale & retail | 2026 |
| Southport Garden Machinery Limited | Wholesale & retail | 2022 |
| Southport Garden Maintenance Ltd | Administrative & support | 2025 |
| Southport Gates and Automation Ltd | Construction | 2024 |
| Southport GC Ltd | Administrative & support | 2024 |
| Southport Getaways Ltd | Hospitality | 2025 |
| Southport Glass Co. Limited | Manufacturing | 1960 |
| Southport Golf Holidays Limited | Real estate | 2025 |
| Southport Growing Together CIC | Health & social care | 2026 |
| Southport Happy Rentals Ltd | Real estate | 2022 |
| Southport Holiday Rentals Limited | Hospitality | 2024 |
| Southport Hospitality Limited | Hospitality | 2021 |
| Southport Inns Limited | Real estate | 1937 |
| Southport Insurance Brokers Limited | Financial services | 1965 |
| Southport International Limited | Education | 2000 |
| Southport Language Centre Ltd | Education | 2022 |
| Southport Learning Trust | Education | 2011 |
| Southport Lets Limited | Real estate | 2017 |
| Southport Logistics Limited | Wholesale & retail | 2020 |
| Southport Maintenance Limited | Other services | 1971 |
| Southport Market Blinds Limited | Wholesale & retail | 2016 |
| Southport Masonic Hall Company Limited(The) | Other services | 1948 |
| Southport Mega Valeting Ltd | Administrative & support | 2024 |
| Southport Motor Co Ltd | Wholesale & retail | 2008 |
| Southport Music Academy Ltd | Education | 2020 |
| Southport Nails Limited | Other services | 2025 |
| Southport Newbe Ltd | Hospitality | 2023 |
| Southport Oak Grange Management Limited | Households | 1995 |
| Southport Old Penny Arcade Limited | Arts & recreation | 2013 |
| Southport Pharmacy Group Limited | Wholesale & retail | 2016 |
| Southport Pier Cafe Limited | Hospitality | 2013 |
| Southport Pier Limited | Arts & recreation | 1999 |
| Southport Pier Train Limited | Arts & recreation | 2018 |
| Southport Properties Limited | Real estate | 2024 |
| Southport Property Developments Limited | Construction | 2014 |
| Southport Property Maintenance Ltd | Construction | 2025 |
| Southport Property Solutions Limited | Construction | 2024 |
| Southport RAW Feeding Ltd | Manufacturing | 2018 |
| Southport Rest Home | Health & social care | 2007 |
| Southport Rock Company Ltd | Wholesale & retail | 2019 |
| Southport Rookery Tennis Limited | Arts & recreation | 2024 |
| Southport Rugby Football Club Limited | Arts & recreation | 2009 |
| Southport Scrap Metal Collection Limited | Wholesale & retail | 2022 |
| Southport Self Store Ltd. | Real estate | 2013 |
| Southport Soup Kitchen | Health & social care | 2010 |
| Southport Sports and Community Centre Community Interest Company | Arts & recreation | 2026 |
| Southport Station Store Ltd | Wholesale & retail | 2025 |
| Southport Stationery Company Limited | Administrative & support | 2025 |
| Southport Storage Ltd | Transport & logistics | 2024 |
| Southport Superstore Limited | Wholesale & retail | 2025 |
| Southport Swimming School of Excellence Limited | Arts & recreation | 2011 |
| Southport Tarmacadam Ltd | Construction | 2014 |
| Southport Taxi Settle Limited | Transport & logistics | 2025 |
| Southport Taxis Ltd | Professional & scientific | 2010 |
| Southport Tiles Ltd | Wholesale & retail | 2015 |
| Southport Timing Chain Specialist Ltd | Wholesale & retail | 2024 |
| Southport Trading Company Ltd | Manufacturing | 2020 |
| Southport Van Services Ltd | Transport & logistics | 2017 |
| Southport Weight Loss Limited | Wholesale & retail | 2014 |
| Southport Workwear Ltd | Manufacturing | 2025 |
| Southwest Knotweed Ltd | Administrative & support | 2011 |
| SP Clinical Services Limited | Health & social care | 2023 |
| SP Luxury Nails & Spa Ltd | Other services | 2023 |
| Space Procurement Limited | Financial services | 2023 |
| Sparkles Boutique Ltd | Wholesale & retail | 2022 |
| Sparkles Mini N ME Limited | Wholesale & retail | 2025 |
| Spartan House Limited | Hospitality | 2013 |
| Specialist Land and Property Ltd | Construction | 2019 |
| Spectrum Consulting (NW) Ltd | Professional & scientific | 2013 |
| Spektaglaze Limited | Manufacturing | 2004 |
| Spencer Brook Commercial Property Ltd. | Real estate | 2012 |
| Spencer Gordon Limited | Real estate | 2011 |
| Spice in Ainsdale Ltd | Hospitality | 2024 |
| Spice Xpress Northwest Ltd | Wholesale & retail | 2024 |
| Spicy Mint Limited | Hospitality | 2017 |
| Spicy Q Productions Ltd | Arts & recreation | 2022 |
| Spinnaker Marketing LLP | | 2017 |
| Spinwell Cycle Works Ltd | Wholesale & retail | 2017 |
| Spirit of Jasmine Limited | Real estate | 2021 |
| Sport Skills Academy LLP | | 2015 |
| Sports Horizons (NW) Limited | Administrative & support | 2022 |
| Spot on Cleaning Services Southport Ltd | Administrative & support | 2018 |
| Springbank (Litherland) Management Company Limited | Households | 2001 |
| Springboard Consulting Limited | Professional & scientific | 2013 |
| Springfield Nursery (Aughton) Limited | Administrative & support | 2002 |
| Sprinkles NW Limited | Wholesale & retail | 2023 |
| Sprintmove Ltd | Transport & logistics | 2013 |
| Sptjam Community Interest Company | Education | 2024 |
| Spydernet Limited | Administrative & support | 2004 |
| Sqircle Consultancy Limited | Professional & scientific | 2009 |
| SQL Testing Limited | Information & communication | 2014 |
| Square Leisure Limited | Hospitality | 2020 |
| Squeakybinsquaduk Ltd | Administrative & support | 2026 |
| SR Joinery and Building Services Limited | Manufacturing | 2022 |
| Srfc Trading Limited | Arts & recreation | 2016 |
| Srqpservices Ltd | Manufacturing | 2022 |
| Ssliderson Group Ltd | Arts & recreation | 2025 |
| SST (NW) Ltd | Construction | 2020 |
| ST Georges Chung Limited | Real estate | 2024 |