| Sldda Ltd | Real estate | 2023 |
| Sleepy Paws Ltd | Wholesale & retail | 2021 |
| Slemani Barber Limited | Other services | 2026 |
| Slice 1 and Dice Limited | Hospitality | 2024 |
| Slips Technology Ltd | Information & communication | 2026 |
| Sloanes Estates Ltd | Real estate | 2025 |
| Sloanes Interior Design Ltd | Professional & scientific | 2023 |
| Slranks Ltd | Health & social care | 2019 |
| SM Wizniuk Transport Ltd. | Transport & logistics | 2019 |
| SM10 Investments Limited | Professional & scientific | 2015 |
| Small and Shouty Poulton Limited | Hospitality | 2017 |
| Smart Bart Ltd | Administrative & support | 2026 |
| Smart Booqs Limited | Professional & scientific | 2021 |
| Smart Lashes Ltd | Other services | 2021 |
| Smart Retrofit Homes Ltd. | Construction | 2023 |
| Smart Shelter Solutions Limited | Construction | 2023 |
| Smaw Property Investment Limited | Real estate | 2021 |
| SMC Heating and Technical GAS Ltd | Construction | 2021 |
| SMH Property Portfolio Ltd | Real estate | 2026 |
| Smhconsult Ltd | Professional & scientific | 2020 |
| Smileomatic Limited | Professional & scientific | 2016 |
| Smith and Co Dining Limited | Hospitality | 2025 |
| Smiths Limited | Real estate | 1912 |
| Smooth Move Conveyancing Ltd | Professional & scientific | 2026 |
| Smyth Croft Management Company Limited | Households | 2003 |
| Snackwallah Ltd | Hospitality | 2019 |
| Snail Construction Ltd | Construction | 2016 |
| SNJ Innovations Ltd | Construction | 2023 |
| SNL Distribution Ltd | Transport & logistics | 2018 |
| Snowdon & Bridge Limited | Wholesale & retail | 1999 |
| SNT Associates Limited | Hospitality | 2013 |
| Snuggy Limited | Real estate | 2018 |
| SO & SO Investments Limited | Real estate | 2017 |
| Soak Away Drainage Solutions Ltd | Water & waste | 2023 |
| Socially Spirited Ltd | Wholesale & retail | 2023 |
| Sodojo Ltd | Administrative & support | 2011 |
| Softpaws Play Centre Ltd | Other services | 2026 |
| SOL Fresh Limited | Agriculture & fishing | 1994 |
| Solarhall | | 1960 |
| Solaroak Media Ltd | Professional & scientific | 2012 |
| Solder BEE Ltd | Professional & scientific | 2024 |
| Solfresh Nurseries Limited | Agriculture & fishing | 1997 |
| Solidum Limited | Real estate | 2011 |
| Solo Swim Limited | Arts & recreation | 2010 |
| Somerset Structural Limited | Other services | 2008 |
| Sonaids Limited | Manufacturing | 2019 |
| Soniza Ltd | Information & communication | 2016 |
| Sooty's and Sweep's Ltd | Administrative & support | 2016 |
| Sorted Labs Ltd | Information & communication | 2026 |
| SOT Holdings Ltd | Real estate | 2016 |
| Soudure Engineering Services Limited | Construction | 2006 |
| Soulstorm Consulting Limited | Professional & scientific | 2026 |
| Sounds Good Ltd | Other services | 2010 |
| South Hawes Holdings Limited | Financial services | 2021 |
| South Hill (Southport) RTM Company Limited | Real estate | 2013 |
| South Ribble Glass (Upvc) Ltd | Construction | 2012 |
| South Rings Energy (NW) Ltd | Extraterritorial | 2022 |
| Southbank Fresh Fish Limited | Extraterritorial | 2002 |
| Southbank Tennis Club | Arts & recreation | 2016 |
| Southbank Tyres Limited | Wholesale & retail | 2010 |
| Southcat Ltd | Hospitality | 2024 |
| Southport & Birkdale Sports Club (Trading) Limited | Hospitality | 2016 |
| Southport & Birkdale Sports Club Limited | Arts & recreation | 2016 |
| Southport & Formby Cancer Information & Support Centre CIC | Health & social care | 2017 |
| Southport Accommodation Ltd | Real estate | 2024 |
| Southport Accountants Ltd | Professional & scientific | 2021 |
| Southport Affordable Housing Ltd | Construction | 2021 |
| Southport Air B & B Limited | Real estate | 2022 |
| Southport and Burscough Removals Ltd | Transport & logistics | 2022 |
| Southport and Formby Health Limited | Health & social care | 2016 |
| Southport and Ormskirk Law Society Incorporated | Professional & scientific | 1922 |
| Southport Aquatic Academy Ltd | Arts & recreation | 2019 |
| Southport Arts Initiative CIC | Arts & recreation | 2025 |
| Southport Athletic Junior Football Club | Arts & recreation | 2024 |
| Southport Auto Electrical Ltd | Manufacturing | 2018 |
| Southport Bacon Co. Limited | Manufacturing | 1983 |
| Southport Barber Limited | Other services | 2023 |
| Southport Bathroom & Kitchens Limited | Construction | 2025 |
| Southport Bathrooms Limited | Construction | 2023 |
| Southport Bijou Cinema CIC | Information & communication | 2017 |
| Southport Bookkeeping Services Ltd | Professional & scientific | 2025 |
| Southport Business Improvement District | Administrative & support | 2014 |
| Southport Climbing Centre & Club Ltd | Education | 2026 |
| Southport Community Sports CIC | Arts & recreation | 2022 |
| Southport Conservative Club Limited | Other services | 2012 |
| Southport Construction & Builders Ltd | Construction | 2022 |
| Southport Container Storage Ltd | Administrative & support | 2020 |
| Southport Contemporary Arts | Education | 2010 |
| Southport Corridor Ltd | Hospitality | 2024 |
| Southport Cruise and Travel Ltd | Administrative & support | 2016 |
| Southport Curry HUT Ltd | Hospitality | 2018 |
| Southport Damp Course Limited | Construction | 2020 |
| Southport Desserts Ltd | Hospitality | 2023 |
| Southport Discount Ltd | Wholesale & retail | 2024 |
| Southport Dogs Limited | Wholesale & retail | 2024 |
| Southport Dogs Superstore Ltd | Wholesale & retail | 2024 |
| Southport Dramatic Club | Arts & recreation | 2015 |
| Southport Driving School Limited | Extraterritorial | 2014 |
| Southport Fitness Ltd. | Arts & recreation | 2017 |
| Southport Football Club Limited | Arts & recreation | 1980 |