| Shandley Limited | Extraterritorial | 2023 |
| Sharbax Limited | Wholesale & retail | 2011 |
| Sharland Group Ltd | Administrative & support | 2017 |
| Sharma Enterprises Ltd | Health & social care | 2019 |
| Sharma Private Enterprises Ltd | Health & social care | 2019 |
| Sharp Automotive Limited | Administrative & support | 2018 |
| Sharpletons Ltd | Real estate | 2023 |
| Shashi Software Solutions Ltd | Information & communication | 2019 |
| Shaun Johnson Limited | Extraterritorial | 2014 |
| Shaw's Fashion Ltd | Wholesale & retail | 2018 |
| Shaws Avenue 1964 Limited | Extraterritorial | 2014 |
| Shaws Jewellery Ltd | Wholesale & retail | 2023 |
| SHD Care Ltd | Health & social care | 2024 |
| Sheaun Civils Limited | Construction | 2018 |
| Shef NW Ltd | Administrative & support | 2025 |
| Shela Limited | Wholesale & retail | 2018 |
| Shell Recycling UK LLP | | 2007 |
| Shell Sell Limited | Information & communication | 2022 |
| Shequal Consultancy Ltd | Professional & scientific | 2011 |
| Sherwood Lodge RTM Company Limited | Households | 2014 |
| Shine Social CIC | Education | 2026 |
| Shipandanchorsouthport Ltd | Hospitality | 2025 |
| Shivshakti Limited | Real estate | 2021 |
| Shock & AWE Films Limited | Information & communication | 2013 |
| Shoppin Ltd | Wholesale & retail | 2022 |
| Shore Road Management Company Limited | Households | 2020 |
| Shoreham Catering Ltd | Hospitality | 2018 |
| Shoreline Church | Other services | 2011 |
| Shoreside Consultancy Ltd | Information & communication | 2013 |
| Shoreside Investments Ltd | Real estate | 2023 |
| Shoreside Property Ltd | Real estate | 2024 |
| Shoresides Shetlands Ltd | Households | 2024 |
| Shoreswood Court Management Company Limited | Households | 2007 |
| Shosbro Digital Ltd | Wholesale & retail | 2024 |
| Shreeka Retail Ltd | Wholesale & retail | 2010 |
| Shukran Gourmet Ltd | Hospitality | 2020 |
| Shush Hair and Beauty Limited | Other services | 2014 |
| SI 430K Ltd | Administrative & support | 2024 |
| SI Meditalk Limited | Wholesale & retail | 2022 |
| SIB Risk Management Limited | Financial services | 2008 |
| Sicily Express Ltd | Hospitality | 2021 |
| Sicompute Ltd | Information & communication | 2013 |
| SID Safety Limited | Professional & scientific | 2014 |
| Sidequest HQ Limited | Wholesale & retail | 2025 |
| Sidetracked Adventures Limited | Administrative & support | 2018 |
| Sidvin Ltd | Health & social care | 2019 |
| Sienna Beauty Academy Ltd | Other services | 2020 |
| Sigma Rollers Kettering Limited | Administrative & support | 2023 |
| Signature GAS Services Ltd | Construction | 2015 |
| Signature Golf UK Ltd | Administrative & support | 2013 |
| Signum 54 Limited | Construction | 2017 |
| Sikasso Limited | Health & social care | 2002 |
| Silcock Leisure Group Limited | Hospitality | 1985 |
| Silverback (Bulk) Haulage Ltd | Transport & logistics | 2025 |
| Silverdale (Birkdale) Residents Association Limited | Households | 2007 |
| Silversmiths LLP | | 2007 |
| Silverstone Heating and GAS Limited | Construction | 2017 |
| Simcris Limited | Real estate | 2011 |
| Simon Ford Jewellery Ltd | Other services | 2023 |
| Simply (NW) Ltd | Hospitality | 2018 |
| Simply Accounts Online Ltd | Professional & scientific | 2010 |
| Simply EJM Limited | Other services | 2022 |
| Simply Homes (UK) Limited | Real estate | 2003 |
| Simply Sports (N.W.) Limited | Arts & recreation | 2016 |
| Simplystay Limited | Hospitality | 2020 |
| Simpson Compliance Ltd | Professional & scientific | 2020 |
| Simpson Consultancy Services Limited | Professional & scientific | 2020 |
| Simpson Heating & Plumbing Ltd | Construction | 2009 |
| Sinclair Maritime Compliance and Consultancy Group Ltd | Professional & scientific | 2026 |
| Sinead Jones Consulting Ltd | Professional & scientific | 2026 |
| Sirnak Consultancy Limited | Real estate | 2023 |
| Sisu Crew C.I.C. | Information & communication | 2024 |
| Site Construction Management Ltd | Construction | 2025 |
| Site Testing Services (National) Ltd | Construction | 2025 |
| Sitting Pretty Laser & Beauty Ltd | Other services | 2025 |
| Sivin Limited | Health & social care | 2014 |
| Sixstore Limited | Wholesale & retail | 2025 |
| SJ & T Properties Limited | Real estate | 2015 |
| SJ Sales Limited | Other services | 2019 |
| SJ Security Systems Ltd | Administrative & support | 2021 |
| SJA Luxe Ltd | Hospitality | 2026 |
| SJB Strategic Solutions Ltd | Professional & scientific | 2025 |
| SJC Apartments RTM Company Limited | Households | 2013 |
| SJL Digital Transformation Solutions Ltd | Information & communication | 2026 |
| SJT Couriers Limited | Transport & logistics | 2025 |
| SK4P Project Management Ltd | Professional & scientific | 2019 |
| SKB Training Ltd | Education | 2015 |
| Skidaddle Soft Play and Party Zone Limited | Arts & recreation | 2016 |
| Skin Deep Therapies Limited | Other services | 2016 |
| Skittleselectricalservices Ltd | Construction | 2025 |
| Sky Blue Property Investors Limited | Real estate | 2022 |
| Sky-High Prof BUS Services Limited | Education | 2018 |
| Skymed Limited | Health & social care | 2012 |
| Skyport Ventures Ltd. | Wholesale & retail | 2025 |
| Skyveda Limited | Hospitality | 2026 |
| Slara Services Ltd | Professional & scientific | 2024 |
| Slater & Barnes Limited | Hospitality | 2024 |
| Slater Mccarthy Ronson Limited | Professional & scientific | 2002 |
| Slawomir Lakomiec Ltd | Other services | 2018 |
| SLD Builders Limited | Construction | 2015 |